A5061370730- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Generative Adversarial Networks and Image Synthesis
- Advanced Image Processing Techniques
- Nanoplatforms for cancer theranostics
- Computer Graphics and Visualization Techniques
- Advanced Vision and Imaging
- Image Enhancement Techniques
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Image and Signal Denoising Methods
- Meteorological Phenomena and Simulations
- Laser-induced spectroscopy and plasma
- Simulation and Modeling Applications
- Photodynamic Therapy Research Studies
- Advanced MRI Techniques and Applications
- Extracellular vesicles in disease
Huazhong University of Science and Technology
2015-2025
Union Hospital
2015-2025
Wuhan Union Hospital
2025
Zhejiang University of Science and Technology
2022-2024
University of Macau
2024
Zhejiang University
2022-2024
Union Hospital
2024
Southwest Forestry University
2024
Tsinghua University
2022-2023
Jiangnan University
2020-2022
By mimicking the RIBE machinery, we provided an indirect radiotherapy approach based on RT-MP for eradication of MPE in mice.
Photodynamic therapy (PDT) is a clinical cancer treatment modality based on the induction of therapeutic reactive oxygen species (ROS), which can trigger immunogenic cell death (ICD). With aim simultaneously improving both PDT-mediated intracellular ROS production and ICD levels, we designed serum albumin (SA)-coated boehmite ("B"; aluminum hydroxide oxide) organic-inorganic scaffold that could be loaded with chlorin e6 (Ce6), photosensitizer, honey bee venom melittin (MLT) peptide, denoted...
Abstract Purpose: This study aimed to assess the antitumor activity and safety of neoadjuvant chemotherapy combined with PD-1 inhibitor camrelizumab in patients locally advanced head neck squamous cell carcinoma (HNSCC). Patients Methods: In this single-center, single-arm, phase 2 trial, resectable stage III–IVB HNSCC received [albumin-bound paclitaxel 260 mg/m2 (or docetaxel 75 mg/m2) plus cisplatin mg/m2] 200 mg on day 1 each 21-day cycle for three cycles, followed by surgery, adjuvant...
Simultaneously targeted treatment of tumor cells and their surrounding growth-supporting immune is a promising strategy to reshape immunosuppressive microenvironment (TME) potentiate host innate adaptive antitumor responses.Methods: We designed series melittin-(RADA)n hybrid peptide sequences with varying self-assembling motifs RADA screened out melittin-(RADA)6 that has an optimal gel-formation ability in vitro activity.Results: The formed (MR52) hydrogel scaffold could be loaded specific...
Cancer cell radioresistance is the primary cause of decreased curability non–small lung cancer (NSCLC) observed in patients receiving definitive radiotherapy (RT). Following RT, a set microenvironmental stress responses triggered, including senescence. However, senescence often ignored designing effective strategies to resolve radioresistance. Herein, we identify senescence-like characteristics cancer-associated fibroblasts (CAFs) after RT and clarify formidable ability CAFs promoting NSCLC...
Recent studies have shown remarkable success in universal style transfer which transfers arbitrary visual styles to content images. However, existing approaches suffer from the aesthetic-unrealistic problem that introduces disharmonious patterns and evident artifacts, making results easy spot real paintings. To address this limitation, we propose AesUST, a novel Aesthetic-enhanced Universal Style Transfer approach can generate aesthetically more realistic pleasing for styles. Specifically,...
Background:The role of senescent cells in the tumor microenvironment (TME) is usually bilateral, and diverse therapeutic approaches, such as radiotherapy chemotherapy, can induce cellular senescence.Cellular interactions are widespread TME, reprogram immune metabolically by producing metabolites.However, how remodel metabolism TME remains unclear.This study aimed to explore precise targets enhance cells-induced anti-tumor immunity from a metabolic perspective. Methods:The vivo senescence...
Abstract Cisplatin-based chemotherapy improves the control of distant metastases in patients with nasopharyngeal carcinoma (NPC); however, around 30% fail treatment due to acquired drug resistance. Epigenetic regulation is known contribute cisplatin resistance; nevertheless, underlying mechanisms remain poorly understood. Here, we showed that lysine-specific demethylase 5B (KDM5B) was overexpressed and correlates tumor progression resistance NPC. We also specific inhibition KDM5B impaired...
Artistic style transfer aims to repaint the content image with learned artistic style. Existing methods can be divided into two categories: small model-based approaches and pre-trained large-scale approaches. Small preserve strucuture, but fail produce highly realistic stylized images introduce artifacts disharmonious patterns; Pre-trained generate struggle preserving structure. To address above issues, we propose ArtBank, a novel framework, while structure of images. Specifically,...
This paper presents a new adversarial training framework for image inpainting with segmentation confusion (SCAT) and contrastive learning. SCAT plays an game between generator network, which provides pixel-level local signals can adapt to images free-form holes. By combining standard global training, the exhibits following three advantages simultaneously: (1) consistency of repaired image, (2) fine texture details (3) flexibility handling Moreover, we propose textural semantic learning...
The Diffusion Transformer plays a pivotal role in advancing text-to-image and text-to-video generation, owing primarily to its inherent scalability. However, existing controlled diffusion transformer methods incur significant parameter computational overheads suffer from inefficient resource allocation due their failure account for the varying relevance of control information across different layers. To address this, we propose Relevance-Guided Efficient Controllable Generation framework,...
Radiotherapy (RT) is used for over 50% of cancer patients and can promote adaptive immunity against tumour antigens. However, the underlying mechanisms remain unclear. Here, we discovered that RT induces release irradiated cell-derived microparticles (RT-MPs), which significantly upregulate MHC-I expression on membranes non-irradiated cells, enhancing recognition killing these cells by T cells. Mechanistically, RT-MPs induce DNA double-strand breaks (DSB) in activating ATM/ATR/CHK1-mediated...
Despite advances in multimodal cancer therapy, such as combining radical surgery with high-intensity chemoradiotherapy, for SMARCB1/INI-1-deficient sinonasal carcinoma (SDSC), the prognosis of patients remains poor. Immunotherapy is gaining increasing popularity a novel treatment strategy tumors. Herein, we report on management three SDSC who received PD-1/PD-L1 inhibitor therapy part based and chemoradiotherapy. All survived demonstrated good clinical remission disease control. To our...
Adaptive resistance to immunotherapy remains a significant challenge in cancer treatment. The reshaping of the tumor immune microenvironment response therapeutic pressures is crucial factor contributing this resistance. Here, by comprehensive metabolic profiling tissues, we identified elevated itaconate anti-PD-1 therapy as an adaptive mechanism that promoted escape and progression. CD8+ T-cell-derived interferon (IFN)-γ induced upregulation cis-aconitate decarboxylase 1 (ACOD1) macrophages...
Osteosarcoma, the most common malignant bone tissue tumor, with a high degree of malignancy, strong metastasis, and early lung can result in extremely mortality, is serious threat to human health.