A5043943583- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
- Protein Degradation and Inhibitors
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- GDF15 and Related Biomarkers
- Radiation Therapy and Dosimetry
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
Union Hospital
2014-2025
Huazhong University of Science and Technology
2014-2025
Shanghai Jiao Tong University
2020-2024
Wuhan Union Hospital
2019-2021
Tongji Hospital
2020
Southern Medical University
2012-2016
The University of Texas MD Anderson Cancer Center
2012-2014
Sun Yat-sen University
2011-2014
Sun Yat-sen University Cancer Center
2011-2014
Radiation Oncology Associates
2012
Cancer cell radioresistance is the primary cause of decreased curability non–small lung cancer (NSCLC) observed in patients receiving definitive radiotherapy (RT). Following RT, a set microenvironmental stress responses triggered, including senescence. However, senescence often ignored designing effective strategies to resolve radioresistance. Herein, we identify senescence-like characteristics cancer-associated fibroblasts (CAFs) after RT and clarify formidable ability CAFs promoting NSCLC...
Background Although immune checkpoint blockade (ICB) has been proven to achieve a persistent therapeutic response in various tumor types, only 20%–40% of patients benefit from this treatment. Radiotherapy (RT) can enhance immunogenicity and improve the ICB response, but outcome achieved by combining these two modalities remains clinically unsatisfactory. We previously uncovered that lysine-specific demethylase 4C (KDM4C) is regulator radiosensitivity lung cancer. However, role KDM4C...
The microRNA miR-138 is dysregulated in several human cancers, but the underlying mechanism remains largely unknown. Here, we report that commonly underexpressed nasopharyngeal carcinoma (NPC) specimens and NPC cell lines. ectopic expression of dramatically suppressed proliferation colony formation vitro inhibited tumorigenesis vivo. Moreover, identified cyclin D1 (CCND1) gene as a novel direct target miR-138. In consistent with knocked-down CCND1, overexpression growth cycle progression...
Abstract Background The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. However, the mechanisms involved in CDK7-mediated immune evasion are unclear non-small cell lung cancer (NSCLC). Methods silencing pharmacologic inhibitors were used to evaluate functions CDK7/p38α/MYC/PD-L1 axis proliferation antiPD-1 therapy resistance. Flow cytometry was performed detect status microenvironment after CDK7 inhibition...
Abstract Background NEK2, a serine/threonine kinase involved in mitosis, has been found to function chromosome instability, tumor progression and metastasis, but its role cervical cancer radioresistance remains unknown. Methods We detected the protein levels of NEK2 carcinoma tissues paired paracarcinoma by immunohistochemistry. The roles oncogenesis were examined using cell growth colony formation assays, EdU assay, apoptosis assay as well vivo mouse model. γ-H2AX Rad51 foci formation,...
Abstract UBE2O, an E2/E3 hybrid ubiquitin-protein ligase, has been implicated in the regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its role cancer radioresistance remains completely unknown. Here, we uncover that UBE2O interacts targets Mxi1 for ubiquitination degradation at K46 residue. Furthermore, show genetical or pharmacological blockade impairs progression lung vitro vivo, these effects can be restored by inhibition. Moreover, demonstrate is...
Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer. However, underlying mechanisms of radioresistance remain elusive. Here, we show that lysine-specific demethylase 4C (KDM4C) overexpressed and correlated with poor prognosis cancer patients. We provide evidence genetical or pharmacological inhibition KDM4C impairs tumorigenesis vitro vivo. Moreover, uncover upregulates TGF-β2 expression by directly reducing H3K9me3 level at promoter then activates...
Radioresistance is regarded as the main cause of local recurrence and distant metastasis in non-small cell lung cancer. However, underlying mechanisms radioresistance remains incompletely understood. In this study, we find that arginine methyltransferase PRMT5 interacts with methylates Mxi1, which promotes binding β-Trcp ligase to facilitating ubiquitination degradation Mxi1 Furthermore, genetic blockade impairs DNA damage repair enhances cancer radiosensitivity vitro vivo, these phenotypes...
Abstract Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in and knockdown increased radiosensitivity cells. Mechanistically, promoted Rad51 gene transcription by increasing level FOXM1 at promoter, thereby inducing formation radioresistance. Furthermore, deguelin, potential inhibitor FBXO22, enhanced an FBXO22/Rad51-dependent manner safely tolerated...
Radioresistance is one of the main reasons for recurrence and metastasis non-small cell lung cancer. Cyclin Y has been implicated in various cellular processes such as growth, proliferation, autophagy, tumor progression. However, function regulatory mechanism cancer radioresistance remain poorly understood. In this study, we find that overexpressed correlates with poor prognosis. Furthermore, knockdown results inhibited growth increases DNA damage, impairs damage repair, enhances...
Rationale:Radioresistance is considered the main cause of local relapse in lung cancer.However, molecular mechanisms radioresistance remain poorly understood.This study investigates role CDK16 human cancer cells.Methods: The expression levels were determined by immunohistochemistry tissues and adjacent normal tissues.Immunoprecipitation assay GST pulldown utilized to detect protein-protein interaction.The phosphorylation p53 was evaluated vitro kinase assay.Poly-ubiquitination examined vivo...
CDP138, a CDK5 binding partner, regulates cell proliferation and migration. However, the mechanisms by which CDP138 functions in these processes remain unclear. In this study, we show that is frequently overexpressed high levels of are correlated with lymph node metastasis lung cancer. Furthermore, provide evidence CDP138-depleted cancer cells exhibit enhanced radiosensitivity as well reduced migration invasion. Mechanistically, identify GDF15, member TGF-β superfamily, key downstream...
Rationale:Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc.However, clinical significances and underlying mechanisms by which Mxi1 regulated in lung cancer remain poorly understood.Methods: Mass spectrometry analysis immunoprecipitation assay were utilized to detect protein-protein interaction.The phosphorylation was evaluated vitro kinase assays.Poly-ubiquitination examined vivo ubiquitination assay.Lung cells...
Cyclin-dependent kinases (CDKs) are the catalytic subunits of a family mammalian heterodimeric serine/threonine that play critical roles in control cell-cycle progression, transcription, and neuronal functions. However, functions, substrates, regulation many CDKs poorly understood. To systematically investigate these features CDKs, we conducted proteomic analysis CDK identified their associated protein complexes two different cell lines using modified SAINT (Significance Analysis...
Abstract Distant metastasis is the leading cause of treatment failure in patients with hepatocellular carcinoma (HCC). However, underlying mechanisms have not been fully elucidated. Here, we report that Leucine zipper tumor suppressor 2 (LZTS2) downregulated and correlated poor prognosis HCC. Furthermore, provide evidence LZTS2 associates p85 to inhibit activation PI3K/AKT signaling impairs HCC tumorigenesis vitro vivo. Moreover, identify as a bona fide substrate E3 ligase β-Trcp protein...
Abstract Background The evasion of the immune response by tumor cells through programmed death-ligand 1 (PD-L1) has been identified as a factor contributing to resistance radioimmunotherapy in lung cancer patients. However, precise molecular mechanisms underlying regulation PD-L1 remain incompletely understood. This study aimed investigate role cyclin-dependent kinase-like (CDKL1) modulation expression and cancer. Methods tumorigenic roles CDKL1 were assessed via cell growth, colony...
Osteosarcoma is the most common primary malignant bone tumor in childhood and adolescence has a propensity for local invasion early lung metastasis. However, current therapies often result chemoresistance, therapeutic target not available clinic osteosarcoma. Here, we report that BRD7 forms complex with anaphase-promoting complex/cyclosome (APC/C) degraded by APC/C(cdh1) APC/C(cdc20) during cell cycle. Moreover, suppressor osteosarcoma, mutant resistant to degradation APC/C more efficient...