A5100354518- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Urinary Bladder and Prostate Research
- Mast cells and histamine
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Pluripotent Stem Cells Research
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- MicroRNA in disease regulation
- Mechanisms of cancer metastasis
- Cancer Genomics and Diagnostics
- Apelin-related biomedical research
- Calcium signaling and nucleotide metabolism
- Bioactive Natural Diterpenoids Research
- Curcumin's Biomedical Applications
- Synthesis of Indole Derivatives
- Virus-based gene therapy research
- Developmental Biology and Gene Regulation
- Advanced Breast Cancer Therapies
Union Hospital
2021-2025
Huazhong University of Science and Technology
2021-2025
Third Affiliated Hospital of Sun Yat-sen University
2018-2024
Sun Yat-sen University
2018-2024
Ministry of Education of the People's Republic of China
2020-2024
First Affiliated Hospital of Xi'an Jiaotong University
2012-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2020
Lanzhou University
2018
Sixth Affiliated Hospital of Kunming Medical University
2018
Kunming Medical University
2018
Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) tumor cells their achievement stem cell traits. Curcumin has recently been found possess anticancer activities via its effect on a variety biological pathways involved cancer progression. In this study, we that could induce prostate EMT invasion through monoamine oxidase A (MAOA)/mammalian...
Abstract CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human malignancies, such as breast cancer. However, their application to other tumor types and intrinsic resistance mechanisms are still unclear. Here, we demonstrate that MYC amplification confers CDK4/6i bladder, prostate cancer cells. Mechanistically, binds the promoter of E3 ubiquitin ligase KLHL42 enhances its transcription, leading RB1 deficiency by inducing both phosphorylated total pRB1 ubiquitination...
Among different molecular candidates, there is growing data to support that long noncoding RNAs (lncRNAs) play a significant role in acute myeloid leukemia (AML). HOXA-AS2 significantly overexpressed variety of tumors and associated with anti-cancer drug resistance, however, little known regarding the expression function chemoresistance AML. In this study, we aimed determine mechanism adriamycin-based chemotherapy resistance AML cells.Quantitative real-time PCR was used detect BM samples ADR...
Although holmium laser enucleation of the prostate has been proven to be an excellent technique for treatment benign prostatic hyperplasia, it not widely applied due technical difficulties and longer operative time. We modified current present our initial experience.A total 189 patients with hyperplasia underwent prostatectomy prostate. Intraoperative postoperative data were prospectively collected. For followup International Prostate Symptom Score, quality life, maximal flow rate post-void...
Detection of cytosolic nucleic acids by pattern recognition receptors leads to the induction type I interferons (IFNs) and elicits innate immune response. We report here identification RIOK3 as a novel adaptor protein that is essential for acid-induced IFN production antiviral response gammaherpesvirus through two independent kinome-wide RNA interference screens. knockdown blocks both double-stranded B-form DNA RNA-induced IRF3 activation IFN-β production. In contrast, overexpression...
This study aimed to investigate the mechanism by which microRNA-206 (miR-206) affects proliferation, apoptosis, migration and invasion of osteosarcoma (OS) cells targeting ANXA2 via AKT signaling pathway.A total 132 OS tissues 120 osteochondroma were examined in this study. The relationship between miR-206 was verified with a dual-luciferase reporter assay. expression ANXA2, AKT, PARP, FASN, Survivin, Bax, Mcl-1 Bcl-1 mRNA protein above two groups qRT-PCR western blotting. cultured divided...
Abstract Distant metastasis is the leading cause of treatment failure in patients with hepatocellular carcinoma (HCC). However, underlying mechanisms have not been fully elucidated. Here, we report that Leucine zipper tumor suppressor 2 (LZTS2) downregulated and correlated poor prognosis HCC. Furthermore, provide evidence LZTS2 associates p85 to inhibit activation PI3K/AKT signaling impairs HCC tumorigenesis vitro vivo. Moreover, identify as a bona fide substrate E3 ligase β-Trcp protein...
Altered expression of microRNA (miRNA) is associated with the occurrence and metastasis various tumors. We previously found that miR-218 inhibits tumor angiogenesis through RICTOR/VEGFA axis in prostate cancer (PCa). In this study, we determined also had a negative effect on cell growth, migration, invasion ability PCa. Our data showed bound to Grb2-associated binding protein 2 (GAB2) 3'-UTR region inhibited GAB2 expression. As novel downstream target miR-218, has been reported be involved...
Both phosphatase and tensin homologue deleted on chromosome ten (PTEN) cluster of differentiation 38 (CD38) have been suggested to be key regulators the pathogenesis asthma. However, precise role molecular mechanisms by which PTEN CD38 are involved in airway remodeling throughout asthma remains poorly understood. This study aimed elucidate Exposure tumor necrosis factor-α (TNF-α) smooth muscle (ASM) cells markedly decreased expression, increased expression CD38. Overexpression suppressed...
IGF-binding protein-3 (IGFBP-3) has been shown to induce apoptosis in an insulin-like growth factor (IGF)‑independent manner various cell systems, however, the underlying molecular mechanisms remain unknown. In present study, we showed that IGFBP-3 significantly enhanced interleukin-24 (IL-24)-induced death prostate cancer (PC) lines vitro. Both addition of medium or enforced expression PC line inhibited activation mammalian target rapamycin (mTOR). Downregulation mTOR/S6K reduced Mcl-1...
Abstract The inhibitor of growth 4 (ING4) is known as a tumor suppressor. expressions ING4 were markedly reduced in human renal clear cell carcinoma (ccRCC) tissues. However, the role (RCC) remains unknown. aim current study was to detect expression level and its potential RCC lines. Our results showed that lowly expressed lines compared with proximal tubular line. Ectopic overexpression inhibited proliferation, migration, invasion properties, well prevented epithelial‐mesenchymal transition...
As a newly epidemic, 2019 coronavirus disease (COVID-19) with concentrated outbreak poses great challenge to medical treatment. The severe and critical patients are complex complicatied the psychological problems, staff overworked under tremendous pressure. surgeon participated in emergency rescue could provide professional treatment for combined surgical diseases, as well specialized training non-surgeon crew, reduce surgical-related mortality. With advantages of good team consciousness,...
Abstract Mitochondrial quality regulation plays an important role in affecting the treatment sensitivity of multiple myeloma (MM). We aimed to develop a mitochondrial genes (MQRGs)‐related prognostic model for MM patients. The Genomic Data Commons‐MM bulk RNA‐seq, mutation, and single‐cell RNA‐seq (scRNA‐seq) dataset were downloaded, MQRGs gene set was collected previous study. “maftools” CIBERSORT used mutation immune‐infiltration analysis. Subsequently, “ConsensusClusterPlus” perform...
RGS18 is a member of the RGS (Regulators G-protein signaling) protein family, involved in megakaryopoiesis, megakaryocyte differentiation and chemotaxis. Here, we created knockout cell line from human embryonic stem by CRISPR/Cas9 mediated gene targeting, to further understand roles these processes. The maintains morphology normal karyotype, retains expression pluripotent marker genes potential vivo. RGS18-/- will facilitate investigation role during multiple cellular processes modeled hematopoiesis.