A5100417394- Metabolomics and Mass Spectrometry Studies
- Climate Change and Health Impacts
- Asymmetric Hydrogenation and Catalysis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Catalytic C–H Functionalization Methods
- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Fungal Infections and Studies
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Pneumocystis jirovecii pneumonia detection and treatment
- Medical Research and Treatments
- Catalytic Cross-Coupling Reactions
- Complementary and Alternative Medicine Studies
- Birth, Development, and Health
- Traditional Chinese Medicine Studies
- Antifungal resistance and susceptibility
- Neonatal Respiratory Health Research
- Tryptophan and brain disorders
Hubei University of Chinese Medicine
2018-2025
Northwestern Polytechnical University
2023-2025
First Affiliated Hospital of Jinan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guang’anmen Hospital
2024
Shandong Normal University
2017-2024
Hubei Academy of Agricultural Sciences
2023-2024
Zhejiang Ocean University
2024
Zhejiang University
2023-2024
Sun Yat-sen University
2017-2024
Wumei Wan (WMW) has been used to address digestive disorder for centuries in traditional Chinese medicine. Previous studies have demonstrated its anti-colitis efficacy, but the underlying mechanism of action remains be further clarified.To investigate mechanisms WMW treatment chronic ulcerative colitis (UC) through network pharmacology and experimental validation.Traditional Medicine Systems Pharmacology (TCMSP) platform were identify ingredients potential targets WMW. The microarray gene...
Neuroprotection against cerebral ischemia can be realized if the brain is preconditioned by previous exposure to a brief period of sublethal ischemia. The present study was undertaken test hypothesis that nitric oxide (NO) produced from neuronal isoform NO synthase (NOS) serves as necessary signal for establishing an ischemia-tolerant state in brain. A newborn rat model hypoxic preconditioning used, wherein hypoxia (8% oxygen) 3 hours renders postnatal day (PND) 6 animals completely...
Inferring appropriate synthesis reaction (i.e., retrosynthesis) routes for newly designed molecules is vital. Recently, computational methods have produced promising single-step retrosynthesis predictions. However, template-based are limited by the known templates; template-free weakly interpretable; and semi deficient with regard to utilizing associations between chemical entities. To address these issues, this paper leverages intra-associations synthons, inter-associations synthons leaving...
Saikosaponin-a and -d, two naturally occurring compounds derived from Bupleurum radix, have been shown to exert anti-cancer activity in several cancer cell lines. However, the effect of combination saikosaponins with chemotherapeutic drugs has never addressed. Thus, we investigated whether these chemosensitization on cisplatin-induced cytotoxicity. Two cervical lines, HeLa Siha, an ovarian line, SKOV3, a non-small lung A549, were treated or cisplatin individually combination. Cell death was...
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one main components Rhizoma Paris polyphyllin, displays selective inhibitory effect on various tumor cells. Here we sought to investigate anti-rheumatoid effects and mechanisms PPI vivo vitro. Materials methods: In vitro, BMMs PEMs were stimulated LPS IFN-γ then treated with PPI. We determined degree activation IKKα/β p65, two...
Human rhinovirus (RV) infection is responsible for the majority of virus-induced asthma exacerbations. Using a mouse model human RV infection, we sought to determine requirement CXCR2, receptor ELR-positive CXC chemokines, RV-induced airway neutrophilia and hyperresponsiveness. Wild-type CXCR2(-/-) mice were inoculated intranasally with RV1B or sham HeLa cell supernatant. Following showed reduced lung neutrophils cholinergic responsiveness compared wild-type mice. Similar results obtained in...
An unprecedented electrochemically regioselective C–H phosphorothiolation and S- to C-[1,4] phosphonyl migration involving indolizines, elemental sulfur, H-phosphonates in an undivided cell has been developed.
Abstract Background It is difficult for orthodontists to accurately predict the growth trend of mandible in children with anterior crossbite. This study aims develop a deep learning model automatically mandibular result into normal or overdeveloped using cephalometric radiographs. Methods A convolutional neural network (CNN) was constructed based on algorithm ResNet50 and trained basis 256 The prediction behavior tested 40 cephalograms visualized by equipped Grad-CAM. performance CNN...
Abstract Loss of the tumor suppressor PTEN is frequently observed in various cancers and promotes tumorigenesis by activating PI3K-AKT pathway. However, effectiveness therapies targeting this pathway limited complex signaling crosstalk compensatory mechanisms. Here, we employed quantitative proteomic phosphoproteomic analyses using MCF10A knockout models to comprehensively map alterations induced loss. Our revealed that deficiency not only activates canonical but also induces widespread...
Context Evodiamine, which is isolated from Evodia rutaecarpa (Rutaceae), possess strong anti-inflammatory, immunomodulatory, and antibacterial properties.Objective The protective effects of evodiamine in asthma were evaluated.Materials methods Thirty-two Sprague-Dawley (SD) rats used, was induced by injecting intraperitoneally with a mixture Al(OH)3 (100 mg) ovalbumin (OA; 1 mg/kg), further exposing them to 2% OA aerosol for week. All animals divided into four groups: control, asthma, 40 80...