A5102773402- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Ferroptosis and cancer prognosis
- Bacteriophages and microbial interactions
- Folate and B Vitamins Research
- interferon and immune responses
- Inflammatory Biomarkers in Disease Prognosis
- Frailty in Older Adults
- Cancer, Lipids, and Metabolism
- Single-cell and spatial transcriptomics
- Mycobacterium research and diagnosis
- Flavonoids in Medical Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Genetic Associations and Epidemiology
- Immune cells in cancer
- Colorectal Cancer Treatments and Studies
- Fluoride Effects and Removal
- Botanical Studies and Applications
- Body Composition Measurement Techniques
- Advanced Glycation End Products research
- Actinomycetales infections and treatment
Huazhong University of Science and Technology
2021-2025
Hubei Cancer Hospital
2021-2025
Peking University Third Hospital
2025
Peking University
2024-2025
Yuncheng University
2025
Sixth Affiliated Hospital of Sun Yat-sen University
2023-2024
Sun Yat-sen University
2023-2024
Nanjing University of Chinese Medicine
2020-2024
University of Chinese Academy of Sciences
2020-2024
Institut Pasteur of Shanghai
2020-2024
Wumei Wan (WMW) has been used to address digestive disorder for centuries in traditional Chinese medicine. Previous studies have demonstrated its anti-colitis efficacy, but the underlying mechanism of action remains be further clarified.To investigate mechanisms WMW treatment chronic ulcerative colitis (UC) through network pharmacology and experimental validation.Traditional Medicine Systems Pharmacology (TCMSP) platform were identify ingredients potential targets WMW. The microarray gene...
Background Obesity exerts a significant detrimental impact on cognitive function. The weight-adjusted waist index (WWI) serves as more precise indicator of visceral obesity that is independent weight, in contrast to body mass (BMI). Still, little research has been conducted the interrelation between WWI and abilities. This investigation explored link older Americans’ Methods Utilizing data from 2011–2014 National Health Nutrition Examination Cross-Sectional Survey, multiple linear regression...
We constructed complex models of SARS-CoV-2 spike protein binding to pangolin or human ACE2, the receptor for virus transmission, and estimated free energy changes using molecular dynamics simulation. can bind both but has a significantly lower affinity ACE2 due increased (9.5 kcal mol −1 ). Human is among most polymorphous genes, which we identified 317 missense single-nucleotide variations (SNVs) from dbSNP database. Three SNVs, E329G (rs143936283), M82I (rs267606406) K26R (rs4646116), had...
Abstract Cancer immunotherapies have achieved unprecedented success in clinic, but they remain largely ineffective some major types of cancer, such as colorectal cancer with microsatellite stability (MSS CRC). It is therefore important to study tumor microenvironment resistant cancers for developing new intervention strategies. In this study, we identify a metabolic cue that determines the unique immune landscape MSS CRC. Through secretion distal cholesterol precursors, which directly...
Abstract Novel X‐shaped conjugated oligothiophenes, which form a family of well‐defined C 4 ‐substituted compounds with core thiophene ring that bears four short‐chain branches containing α–α and α–β linkages, have been designed synthesized by facile synthetic route. Their optoelectronic properties can be electronically fine‐tuned manipulating the segments branches. In solution, show strong photoluminescence emission maxima located at 459, 491, 494, 547 nm. The optical their films suggest an...
Growing evidence suggests that nutritional status and inflammation are associated with survival in various cancers. This study aimed to evaluate the prognostic value of index (PNI), geriatric risk (GNRI), systemic inflammatory indexes (neutrophil/lymphocyte ratio [NLR], monocyte/lymphocyte [MLR], platelet/lymphocyte [PLR]) patients stage IIB-III cervical cancer receiving radiotherapy.The ideal cutoff values for PNI, GNRI, NLR, MLR, PLR were 48.3, 97.04, 2.8, 0.41, 186.67, respectively. Low...
To investigate the effect of emollient on atopic march in a murine model dermatitis (AD). Following induction AD with topical calcipotriol (MC903) and ovalbumin (OVA), one group mice was treated topically linoleic acid-ceramide-containing emollient, while without treatment served as disease controls. After 28 days, clinical, histological transcriptomic analyses were performed skin lesions lung well serum cytokine levels. Treatments MC903 OVA induced typical phenotype AD, accompanied by...
As an assessment tool of nutritional status and inflammation, the advanced lung cancer inflammation index (ALI) is associated with survival in various cancers. We aimed to investigate association between ALI's prognostic value time patients stage IIB-III cervical treated radiotherapy. retrospectively screened diagnosed underwent radiotherapy a single institution September 2013 2015. The ALI was calculated as body mass * serum albumin/neutrophil-to-lymphocyte ratio. cut-off determined by...
Jian-pi-yang-zheng Decoction (JPYZ) is a traditional Chinese medicine that used for the treatment of advanced gastric cancer, and it shows good efficacy in patients. A previous study indicated JPYZ inhibited progression cancer via regulation tumor-associated macrophages (TAMs), but underlying molecular target TAMs has not been determined. The present modified-JPYZ (mJPYZ) to extend our investigation cancer. Our results showed mJPYZ vivo vitro. We found decreased activity PI3-kinase γ (PI3Kγ)...
Abstract A Cu 2 O/g‐C 3 N 4 /WS triple‐layer photocathode was fabricated by using a layer‐by‐layer assembly method for photoelectrochemical hydrogen evolution. O electrodeposited on the FTO as active layer light harvesting. The chemically inert g‐C can protect unstable and form p‐n junction with to increase light‐to‐electricity conversion efficiency. Mixed‐phase WS nanosheets were obtained through lithium insertion used an effective evolution catalyst photocurrent‐to‐hydrogen conversion....
Gut microbiota is a complex microecosystem, which called the second genome of human body. Herbal medicine can balance tumor-suppressing bacteria and tumor-promoting exert its anti-cancer effect by regulating gut microbiota. Traditional Chinese (TCM) has history thousands years in prevention treatment diseases China. In recent decades, TCM been shown to have an obvious advantage prolonging survival time improving living quality patients with cancer. Notably, become new pathway understanding...
Background The pathogenesis of COVID-19 emerges as complex, with multiple factors leading to injury different organs. Some the studies on aspects SARS-CoV-2 cell entry and innate immunity have produced seemingly contradictory claims. In this situation, a comprehensive comparative analysis large number related datasets from several could bring more clarity, which is imperative for therapy development. Methods We therefore performed study, analyzing RNA-Seq data infections SARS-CoV-2, SARS-CoV...
As assessment tools of nutritional status, the controlling status (CONUT) and modified (mCONUT) score are associated with survival in various cancers. We aimed to investigate association between CONUT/mCONUT score's prognostic value time patients FIGO stage IIB–IIIB cervical cancer treated radiotherapy. In this retrospective study, 165 September 2013 2015 were analyzed, optimal cut-off values determined using receiver operating characteristic curves. Propensity matching (PSM) was used...
Traditional Chinese medicine (TCM) is increasingly extensively being applied as a complementary and alternative therapy for gastric cancer (GC); however, there lack of large-scale evidence-based deep learning the guidance its clinical prescription.The combinational search terms "Gastric and/or malignancy" "Traditional Medicine" were used to retrieve study-based herbal prescriptions from public database over past 3 decades [1990-2020]. Association rules mining (ARM) was analyze prescription...