A5048500254- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Signaling Pathways in Disease
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microtubule and mitosis dynamics
- Colorectal Cancer Surgical Treatments
- Lung Cancer Research Studies
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Cancer-related gene regulation
- Plant Stress Responses and Tolerance
- Salmonella and Campylobacter epidemiology
- Selenium in Biological Systems
- Gastric Cancer Management and Outcomes
- Graphene and Nanomaterials Applications
- Vibrio bacteria research studies
Universitätsmedizin Göttingen
2018-2025
Northwest A&F University
2014-2024
Sichuan University
2016-2024
Hebei Medical University
2023-2024
Guangzhou Medical University
2024
Second People’s Hospital of Huai’an
2024
Fourth Hospital of Hebei Medical University
2023-2024
University of Manchester
2020-2024
West China Hospital of Sichuan University
2018-2024
Qingdao University
2023-2024
Oxidative stress in depression is a prime cause of neurotransmitter metabolism dysfunction the brain. Acetylcholinesterase (AChE), key hydrolase cholinergic system, directly determines degradation neurotransmitters. However, due to complexity brain and lack appropriate situ imaging tools, mechanism underlying changes AChE activity remains unclear. Hence, we generated two-photon fluorescence probe (MCYN) for real-time visualization with excellent sensitivity selectivity. can specifically...
Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) novel discovery strategy selective protein degradation from within cells.
Vascular smooth muscle cell (VSMC) senescence is crucial for the development of atherosclerosis, characterized by metabolic abnormalities. Tumour necrosis factor receptor-associated protein 1 (TRAP1), a regulator associated with ageing, might be implicated in atherosclerosis. As role TRAP1 atherosclerosis remains elusive, this study aimed to examine function VSMC and
Abstract Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA‐sequence dataset patients (GSE149614) for cell‐cell communication. Flow cytometry, EDU staining, H3‐Ser28 confocal immunofluorescence western blotting and naked microsubcutaneous tumors performed NGF‐NGFR promoting proliferation. Results present study has revealed that during process T‐cell infiltration...
Astaxanthin (AST) is a carotenoid pigment which possesses potent antioxidative, anti-inflammatory, and neuroprotective properties. The aim of this study was to investigate whether administration AST had protective effects on D-galactose-induced brain aging in rats, further examined its mechanisms. results showed that treatment significantly restored the activities glutathione peroxidase (GSH-PX) superoxide dismutase (SOD), increased (GSH) contents total antioxidant capacity (T-AOC), but...
Punicalagin, an essential component of pomegranate rind, has been demonstrated to possess antimicrobial activity against several food-borne pathogens, but its on the virulence pathogens and anti-quorum-sensing (anti-QS) potential have rarely reported. This study investigated efficacy subinhibitory concentrations punicalagin Salmonella factors QS systems. A broth microdilution method was used determine MICs for 10 strains. Motility assay quantitative reverse transcription (RT)-PCR were...
Recent studies have thoroughly described genome-wide expression patterns defining molecular subtypes of pancreatic ductal adenocarcinoma (PDAC), with different prognostic and predictive implications. Although the reversible nature key regulatory transcription circuits two extreme PDAC subtype lineages "classical" "basal-like" suggests that states are not permanently encoded but underlie a certain degree plasticity, pharmacologically actionable drivers identity remain elusive. Here, we...
Aging is closely associated with atherosclerosis.Macrophages accumulate in atherosclerotic lesions contributing to the development and progression of atherosclerosis.Although are known contain senescent cells, mechanism underlying formation macrophages during atherosclerosis still unclear.In this study, different origins were collected, including THP-1 macrophages, telomerase reverse transcriptase knock out (Tert -/-) mouse peritoneal human peripheral blood mononuclear cells (PBMCs).We found...
ARID1A (AT-rich interactive domain-containing protein 1A) is a subunit of the BAF chromatin remodeling complex and plays roles in transcriptional regulation DNA damage response. Mutations that lead to inactivation or loss expression are frequent widespread across many cancer types including colorectal (CRC). A tumor suppressor role has been established number CRC where genetic Arid1a alone led formation invasive adenocarcinomas mice. Mechanistically, described largely function through...
Maternal nutrition during different stages of pregnancy can induce significant changes in the structure, physiology, and metabolism offspring. These could have important implications on food animal production especially if these perturbations impact muscle adipose tissue development. Here, we evaluated maternal isoenergetic diets, alfalfa haylage (HY; fiber), corn (CN; starch), dried distillers grains (DG; fiber plus protein fat), transcriptome fetal tissues sheep. Prepartum diets were...
Abstract Background Increased inclusion of plant proteins in aquafeeds has become a common practice due to the high cost and limited supply fish meal but generally leads inferior growth performance health problems fish. Effective method is needed improve utilization eliminate their negative effects on This study took unique approach soybean (SBM) by through autochthonous plant-degrading microbe isolation subsequent fermentation. Results A strain Shewanella sp. MR-7 was isolated identified as...
Dynamic miRNA alteration is known to occur in colitis-associated colon cancer (CAC), while the molecular mechanisms underpinning how miRNAs modulate development from chronic inflammation CAC lacking. For first time, we constructed knockout (KO) mice for individual miR-148/152 family members and entire family. Based on these KO mice, conduct comprehensive analysis of family, demonstrating that deficiency any member aggravate colitis CAC. Loss or full-family enhance MMP10 MMP13 expression,...
Abstract Osteosarcoma (OS) is a common type of bone tumor for which there has been limited therapeutic progress over the past three decades. The prevalence transcriptional addiction in cancer cells emphasizes biological significance and clinical relevance super-enhancers. In this study, we found that Max-like protein X (MLX), member Myc-MLX network, driven by Upregulation MLX predicts poor prognosis osteosarcoma. Knockdown impairs growth metastasis osteosarcoma vivo vitro. Transcriptomic...
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with 5-year survival rate of 12%. It has two major molecular subtypes: classical and basal, regulated by the master transcription factors (MTFs) GATA6 ΔNp63, respectively. Objective This study sought to uncover transcriptional regulatory mechanisms controlling PDAC subtype identity. Design We integrated primary tumour single-cell RNA-seq, patient-derived xenograft RNA-seq multispectral imaging identify...
Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues. Here, we use computational modeling and single-cell genomics to thoroughly interrogate origin clonal across various biological settings. Our findings reveal that majority which specifically present a subpopulation, termed subpopulation-specific variants, pre-existing...