A5101887744- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- RNA regulation and disease
- Invertebrate Immune Response Mechanisms
- Kruppel-like factors research
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Porphyrin Metabolism and Disorders
- Anaerobic Digestion and Biogas Production
- Hippo pathway signaling and YAP/TAZ
- Optical Coherence Tomography Applications
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
- Transgenic Plants and Applications
- Heme Oxygenase-1 and Carbon Monoxide
Qingdao University
2019-2024
Affiliated Hospital of Qingdao University
2019-2024
Ocean University of China
2022-2024
Wuhan Sports University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2021-2024
Erasmus MC
2020-2022
Stockholm University
2019-2022
Third Affiliated Hospital of Guangzhou Medical University
2021
Guangzhou Medical University
2021
Northern Jiangsu People's Hospital
2021
Abstract Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution Epithelial-to-Mesenchymal Transition (EMT), migratory cellular program associated with development tumor metastasis, fueled by upregulation ribosome during G1/S arrest. This unexpected EMT feature independent species initiating signal, accompanied release the repressive nucleolar chromatin remodeling complex (NoRC) from rDNA, together recruitment EMT-driving transcription factor...
Abstract Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA‐sequence dataset patients (GSE149614) for cell‐cell communication. Flow cytometry, EDU staining, H3‐Ser28 confocal immunofluorescence western blotting and naked microsubcutaneous tumors performed NGF‐NGFR promoting proliferation. Results present study has revealed that during process T‐cell infiltration...
We aimed to investigate potential of urinary cell-free microRNA-214 (miR-214) as a noninvasive biomarker for bladder cancer in this report.We screened miR-214 expression medium from 2 cell lines determine whether it is secretory. Then we validated urine samples an independent set 192 preoperative patients, 80 matching postoperative patients and 169 healthy controls.miR-214 was secreted lines. Cell-free levels were significantly attenuated whereas its increased matched urine. Underexpressed...
BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling complexes mainly associated with transcriptional initiation. They also have a role in alternative splicing, which has been shown for BRM-containing at few genes. Here, we identified subset genes harbour exons that affected by ATPases expressing C33A cells, BRG1- BRM-deficient cell line, analysed effect on splicing RNA sequencing. BRM-affected sub-sets favouring both exon inclusion skipping, only minor overlap...
The rate of fat graft survival is a critical aspect successful surgery and has been matter concern for over 20 years. Owing to their anti-inflammatory effects regenerative property, adipose-derived mesenchymal stem cells (AD-MSCs) have adapted clinical application in grafting, although the mechanism underlying action remains unclear. Recently, exosomes derived from MSCs were suggested as better alternative, these also applied diverse therapies. Accumulating evidence suggests that modulate...
The production of lactate under hypoxic conditions or by cancer cells was reported to promote the M2 polarization tumor‑associated macrophages. However, exact effect on macrophages, particularly conditions, has remained largely elusive. In present study, an in‑depth bioinformatics analysis previously published transcriptome data macrophages performed. A total 6, 101 and 764 upregulated genes were identified in lactate, hypoxia hypoxia‑lactate groups, respectively, whereas 4, 41 588...
The endoplasmic reticulum–associated degradation (ERAD) pathway mediates the reticulum–to–cytosol retrotranslocation of defective proteins through protein complexes called retrotranslocons. Defective usually have complex conformations and topologies, it is unclear how ERAD can thread these conformationally diverse substrates Here, we investigated substrate conformation flexibility necessary for transport via retrotranslocons on ERAD-L, ERAD-M, HIV-encoded Vpu-hijacked branches. To this end,...
Secretory immunoglobulin (SIg) is crucial for mucosal surface defenses, but the transepithelial secretion of SIg mediated by polymeric receptor (pIgR) not clarified in fish. We previously found that flounder ( Paralichthys olivaceus ) pIgR (fpIgR) and secretory IgM (SIgM) increased gut mucus post-vaccination. Here, fpIgR-positive signal was mainly observed intestinal epithelium, whereas IgM-positive distributed lamina propria, before immunization. signals propria then epithelium after...
Abstract Angiogenesis is an important process in atherosclerosis. ErbB2 was proved to have role vascular development, but it still unclear whether Erbin expresses vessels as well its location and function the vessels. In current study, we investigated of human umbilical veins. The veins were prepared, immunofluorescent analysis performed determine expression Erbin. Human vein endothelial cells (HUVECs) cultured lentivirus (LV) containing RNAi also prepared. After transfection with...
p53 gene mutations are associated with human tumors, and among the most common genetic abnormalities. To understand relationship between glycine decarboxylase (GLDC) expression in B cell lymphoma, we established lymphoma animal models to study GLDC mice.Based on immunohistochemical staining results, BALB/c nude mice were divided into a protein-positive group protein-negative group. mRNA was determined by real-time polymerase chain reaction, protein Western blot. We designed GLDC-specific...
Regulation of ribosomal transcription is under tight control from environmental stimuli, and this involves changes in the chromatin structure. The underlying mechanism how response to nutrient energy supply cell still unclear. chromatin-remodeling complex B-WICH involved activating transcription, we show here that knock down component WSTF results cells do not respond glucose. promoter less accessible, RNA pol I its factors SL1/TIF-1B RRN3/TIF-1A, as well proto-oncogene c-MYC deacetylase...
Cancer remains a global health challenge, demanding early detection and accurate diagnosis for improved patient outcomes. An intelligent paradigm is introduced that elevates label-free nonlinear optical imaging with contrastive patch-wise learning, yielding stain-free computational histology (NOCH). NOCH enables swift, precise diagnostic analysis of fresh tissues, reducing anxiety healthcare costs. Nonlinear modalities are evaluated, including stimulated Raman scattering multiphoton imaging,...
Abstract BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling complexes. The function complexes in transcriptional initiation has been well studied, while a alternative splicing only studied for few cases BRM-containing Here, we have expressed C33A cells, BRM-deficient cell line, analysed effects on transcriptome by RNA sequencing. We shown that expression affects subset genes. For some, favours exon inclusion others, skipping. Some changes induced do not require...
<title>Abstract</title> Exosomes from Adipose-derived stem cells (ADSCs) have been demonstrated to benefit angiogenesis, wound healing and fat grafting. Small noncoding RNAs such as microRNA (miRNA) circular RNA play critical role mediating the function of ADSC-derived exosomes. However, underlying mechanisms not fully elucidated. In this study, we investigated mechanism exosome promoting graft angiogenesis adipogenic differentiation. ADSCs were isolated identified while treatment with...