A5115602277- Pulsars and Gravitational Waves Research
- Gamma-ray bursts and supernovae
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Astrophysical Phenomena and Observations
- Cosmology and Gravitation Theories
- Particle physics theoretical and experimental studies
- Geophysics and Sensor Technology
- Geophysics and Gravity Measurements
- Seismic Waves and Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- High-pressure geophysics and materials
- High-Energy Particle Collisions Research
- Prostate Cancer Treatment and Research
- Adipose Tissue and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Quantum Chromodynamics and Particle Interactions
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Cerebrovascular and Carotid Artery Diseases
- Ocular Surface and Contact Lens
- Astrophysics and Cosmic Phenomena
- Dark Matter and Cosmic Phenomena
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
Peking University
2012-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
Laboratoire AstroParticule et Cosmologie
2023-2025
Université Paris Cité
2015-2025
University of Electronic Science and Technology of China
2025
Beihang University
2025
Chongqing Medical University
2024-2025
Nanjing Medical University
2023-2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2025
Epidemiological studies have supported the premise that an adequate selenium intake is essential for thyroid gland function.The objective was to investigate whether prevalence of disease differed in two areas were similar, except very different soil/crop concentrations.Cross-sectional observational study.The setting counties Shaanxi Province, China, here defined as adequate- and low-selenium.A total 6152 participants selected by stratified cluster-sampling.Participants completed demographic...
PhosphatidylethanolamineN-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). We investigated whether there was diminished secretion lipoproteins from hepatocytes derived mice that lacked PEMT (Pemt −/−) compared with Pemt +/+ mice. Hepatocytes were incubated 0.75 mm oleate, media harvested, and triacylglycerol (TG), PC, apolipoprotein (apo) B100, apoB48 isolated quantified. Compared mice, −/− secreted 50% less TG, whereas PC unaffected....
Phosphatidylcholine (PC) is synthesized through the Kennedy pathway, but more than 50% of PC remodeled Lands cycle, i.e. deacylation and reacylation to attain final proper fatty acids within PC. The step catalyzed by lysophosphatidylcholine acyltransferase (LPCAT), we report here identification a novel LPCAT, which named LPCAT3. LPCAT3 belongs membrane-bound O-acyltransferase (MBOAT) family encodes protein 487 amino with calculated molecular mass 56 kDa. Membranes from HEK293 cells...
Numerous astrophysical and cosmological observations are best explained by the existence of dark matter, a mass density which interacts only very weakly with visible, baryonic matter. Searching for extremely weak signals produced this matter strongly motivate development new, ultra-sensitive detector technologies. Paradigmatic advances in control readout massive mechanical systems, both classical quantum regimes, have enabled unprecedented levels sensitivity. In white paper, we outline...
The astrophysical reach of current and future ground-based gravitational-wave detectors is mostly limited by quantum noise, induced vacuum fluctuations entering the detector output port. replacement this ordinary field with a squeezed has proven to be an effective strategy mitigate such noise it currently used in advanced detectors. However, squeezing cannot improve across whole spectrum because Heisenberg uncertainty principle: when shot at high frequencies reduced, radiation pressure low...
AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family that appears to be important in triglyceride biosynthesis several tissues, but precise biochemical function enzyme unknown. In current study, we show microsomal glycerol-3-phosphate acyltransferase (GPAT). Membranes from HEK293 cells overexpressing human had higher levels GPAT activity. Substrate specificity studies suggested was active against both saturated and unsaturated long-chain fatty acyl-CoAs. Both...
Despite recent advances in the understanding of role NLRP3 inflammasomes coronary atherosclerosis, further work on their activation and clinical implications remains to be performed. In this study, we aimed evaluate effect dose rosuvastatin cathepsin-B expression peripheral blood monocytes patients with acute syndrome.A total 123 participants were enrolled study; these included myocardial infarction (AMI) (n=53), unstable angina (UA, n=40), normal controls (n=30). AMI UA divided into...
To explore the composition of ocular microbiome in normal subjects and patients with Meibomian gland dysfunction (MGD).Seventy (140 eyes) were enrolled our study. Signs dry eye evaluated bacterial species conjunctival sac (CS) (MG) secretions then identified by 16S rRNA gene sequencing. Additionally, 17 (34 further to determine differences microbiomes surface deep layers MG using a segmental secretion analysis.The positive isolation rate was markedly higher than CS. The control mild group...
Abstract Considering the nuclear fuel reprocessing conditions at 75 °C and oxidizability of iodine, thermal chemical stabilities are especially important for porous materials to enrich iodine. However, most organic or metal coordinated hardly meet this long‐term demand. Here, highly carbon is prepared from pyrolysis high temperature using triptycene‐based hypercrosslinked polymer as precursor, possesses Brunauer–Emmett–Teller (BET) surface area 3125 m 2 g −1 pore volume 1.60 cm 3 , exhibits...
N7-methylguanosine (m7G) modification is, a more common epigenetic in addition to m6A modification, mainly found mRNA capsids, interiors, transfer RNA (tRNA), pri-miRNA, and ribosomal (rRNA). It has been that m7G modifications play an important role transcription, tRNA stability, rRNA processing maturation, miRNA biosynthesis. However, the of within its "writer" methyltransferase 1(METTL1) tumors, particularly prostate cancer (PCa), not revealed.The differential expression level METTL1...
Background The hemodynamics of brain arteriovenous malformations (AVMs) may have implications for hemorrhage. This study aimed to explore the ruptured AVMs by direct microcatheter intravascular pressure monitoring (MIPM) and indirect quantitative digital subtraction angiography (QDSA). Methods We recruited patients with at a tertiary neurosurgery center from October 2020 March 2023. In terms MIPM, we preoperatively super-selected predominant feeding artery main draining vein through measure...
CTP:phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in CDP-choline pathway for biosynthesis of phosphatidylcholine (PC). We previously generated a mouse which hepatic CTalpha gene was specifically inactivated by cre/loxP procedure. In knock-out mice, plasma high density lipoprotein (HDL) and very low (VLDL) levels were markedly lower than wild type mice (Jacobs, R. L., Devlin, C., Tabas, I., Vance, D. E. (2004) J. Biol. Chem. 279, 47402-47410.) To investigate...
Abstract Epidemiology studies suggest that statins and nonsteroidal anti-inflammatory drugs reduce the risk of prostate cancer. In present study, LNCaP cells were cultured in regular medium containing fetal bovine serum or supplemented with charcoal-stripped to mimic androgen deprivation treatment. We found atorvastatin (Lipitor) celecoxib (Celebrex) treatment androgen-depleted inhibited growth stimulated apoptosis. A combination was more effective than either agent alone. animal studies,...
Human cloned blastocysts generated from oocytes following in vitro maturation (IVM) are a potential resource for embryonic stem cells (ESC) with homologous immune systems. The purpose of this study was to evaluate the effects multiple growth factors [epidermal factor (EGF), brain-derived neurotrophic (BDNF) and insulin-like factor-1 (IGF-1)] on human oocyte maturation, early embryo development, blastocyst formation ESC line generation. Patients (n= 344) undergoing IVF owing male infertility...
In this paper, based on a 2.29 GHz VLBI all-sky survey of 613 milliarcsecond ultra-compact radio sources with 0.0035<z<3.787, we describe method identifying the sub-sample which can serve as individual standard rulers in cosmology. If linear size compact structure is assumed to depend source luminosity and redshift lm=l Lβ (1+z)n, only intermediate-luminosity quasars (1027 W/Hz<L< 1028 W/Hz) show negligible dependence (|n|≃ 10−3, |β|≃ 10−4), thus represent population such fixed...
Abstract Background Salt, a common environmental stress factor, inhibits plant growth and reduces yields. Melatonin is pleiotropic molecule that regulates can alleviate in plants. All previous research on this topic has focused the use of melatonin to improve relatively low salt tolerance glycophytes by promoting enhancing antioxidant ability. It unclear whether exogenous increase halophytes, particularly recretohalophytes, secretion from glands. Results To examine mechanisms...
Human exposure to methylmercury (MeHg) from consuming contaminated fish has been a major concern for decades. Besides, human MeHg through rice consumption recently found be important in some Asian countries. China is the largest country on mercury (Hg) production, consumption, and anthropogenic emission. However, health risks of Hg are not fully understood. A total 624 fish, 299 rice, 994 hair samples were collected typical Hg-contaminated areas fish-rich assess China. Fish showed relatively...
Background: Brain arteriovenous malformations (AVMs) account for 25% of hemorrhagic strokes in young adults. Although embolization has been widely performed as a stand-alone procedure to cure brain AVM, it is undermined whether patients benefit from this treatment. This study aimed compare the long-term outcome stroke or death with either conservative management AVM. Methods: The population was derived nationwide multicenter prospective collaboration registry (the *BLINDED* registry) between...
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Purpose: Changes associated with Alzheimer's disease (AD) may have measurable effects on the retina, which facilitate early detection due to eye's accessibility. Retinal pathology and regulation of serine racemase (SR) were investigated in retinas APP(SW)/PS1(∆E9) mice. Methods: SR content D-serine aqueous humor analyzed. The structure function retina assessed. Additionally, primary Müller cell cultures was investigated. Results: levels significantly higher 18- 24-month-old male APP/PS1...
Obsessive-compulsive disorder (OCD) is a mental health condition significantly affecting people's quality of life. Although OCD can be effectively treated with evidence-based therapy (e.g., exposure and response prevention), Managing symptoms independently, as an indispensable part successful treatment, remains challenging due to fear confrontation lack appropriate support. We aim comprehensively understand the challenges needs in self-management from perspectives both people therapists....