A5027150115- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Neurological Complications and Syndromes
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Healthcare and Venom Research
- Cardiovascular Function and Risk Factors
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Organ Transplantation Techniques and Outcomes
- Natural Compounds in Disease Treatment
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
Beijing Anzhen Hospital
2024-2025
Capital Medical University
2012-2025
Shanxi Medical University
2018-2025
First Hospital of Shanxi Medical University
2023-2025
Chongqing Medical and Pharmaceutical College
2024
Zhejiang Cancer Hospital
2012-2024
Chinese Academy of Sciences
2024
Shanghai University of Medicine and Health Sciences
2024
Nanjing Drum Tower Hospital
2021-2024
Nankai University
2024
Background: Brain arteriovenous malformations (AVMs) account for 25% of hemorrhagic strokes in young adults. Although embolization has been widely performed as a stand-alone procedure to cure brain AVM, it is undermined whether patients benefit from this treatment. This study aimed compare the long-term outcome stroke or death with either conservative management AVM. Methods: The population was derived nationwide multicenter prospective collaboration registry (the *BLINDED* registry) between...
It is unclear whether diabetes mellitus (DM) affects the role of malnutrition in heart failure (HF). We evaluated effect geriatric nutritional risk index (GNRI) on HF prognosis and DM's this relationship. This single-centre retrospective cohort study included 540 patients with data grouped by DM status GNRI score. The primary endpoint was all-cause mortality. Eighty-four (15.6%) were classified as malnourished (GNRI ≤ 98). Over a median follow-up 4.0 years, 102 died. DM/low (L-GNRI) group...
Cancer therapy has moved from single agents to more mechanism-based targeted approaches. In recent years, the combination of HDAC inhibitors and other anticancer chemicals produced exciting progress in cancer treatment. Herein, we developed a novel prodrug via ligation dichloroacetate selenium-containing potent inhibitors. The effect mechanism this compound treatment prostate were also studied.
Objective Although a few reports suggested that cognitive function impairment could be found in adult patients with moyamoya disease (MMD), there were still many aspects are unclear. The aim of our study was to assess the MMD and its clinical subtypes. Methods 49 23 healthy controls asked take tests. Cognitive tests included IQ, prospective memory (PM), immediate (IM), verbal fluency (VF), visual breadth, attention, retrospective (RM), Stroop test, Wisconsin Card Sorting Test, Trail-Making...
Aims CD 155 is an important ligand in triggering tumour rejection by immune cells. However, the expression of and its clinical significance hepatocellular carcinoma ( HCC ) remains unknown. Methods results We examined level 174 tissue samples immunohistochemical staining cell lines flow cytometry; 63.8% (111 174) showed negative expression. When compared with adjacent peritumour tissues, tissues exhibited a significantly lower P < 0.001). Flow cytometry analysis indicated that had low...
SKA1, an important mitosis protein, has been indicated in the initiation and progression of several malignancies. However, its clinical significance hepatocellular carcinoma (HCC) remain to be elucidated.mRNA expression SKA1 was examined 126 HCC paired non-neoplastic tissues using real-time PCR validated The Cancer Genome Atlas (TCGA) database. protein detected immunohistochemistry associations with clinicopathological parameters prognosis were analyzed. Hierarchical cluster analysis gene...
ERBB2 (HER2) is a driver gene identified in non-small cell lung cancer (NSCLC). The prevalence, clinicopathology, genetic variability and treatment of HER2-positive NSCLC Chinese population are unclear.Eight hundred fifty-nine patients with pathologically confirmed were screened for HER2 mutations using Sanger sequencing. Next-generation sequencing (NGS) was performed positive cases. amplification detected FISH. Overall survival (OS) evaluated Kaplan-Meier methods compared log-rank...
Object Moyamoya disease (MMD) is a common and chronic progressive stenotic-occlusive cerebrovascular in Eastern Asia. To evaluate the hemispheric haemodynamic status of adult patients with MMD, we explored potential risk factors perfusion alterations CT (CTP) DSA. Methods We retrospectively reviewed 44 male female (176 hemispheres) MMD who had both DSA CTP. Data on cerebral blood (CBF), volume (CBV), mean transmit time (MTT), to peak (TTP) hemisphere cerebellum were gathered difference...
To investigate the incidence, risk factors, and clinical prognosis of cerebral hyperperfusion syndrome (CHS) after superficial temporal artery-middle artery anastomosis combined with encephalo-duro-arterio-synangiosis (STA-MCA/EDAS) in adult patients moyamoya disease (MMD).The data 160 MMD treated by STA-MCA/EDAS from January 2016 to 2017 were retrospectively analyzed. According CHS diagnosis, divided into non-CHS group. Univariate multivariate analysis factors Kaplan-Meier curve stroke-free...
Abstract Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of internal carotid arteries formation compensatory collateral vessels. The etiology MMD remains enigmatic, making diagnosis management challenging. MOYAOMICS project was initiated to investigate molecular underpinnings explore potential diagnostic therapeutic strategies. Methods employs multidisciplinary approach, integrating various omics technologies,...
Abstract Background and objective The research on the effect of anesthesia endovascular therapy (EVT) acute ischemic stroke is mainly focused anterior circulation, little known about data basilar artery occlusion (BAO). This study aims to investigate association strategy with 90-day clinical outcomes patients BAO treated EVT. Methods We reviewed our prospectively collected from treatment database at Beijing Tiantan Hospital. included who had a documented modified Rankin Scale (mRS) score...
To determine the clinical effect, treatment times, and rheoencephalogram changes in vertebral artery type cervical spondylosis patients treated with innovative Tuina manipulations.One hundred twenty six (vertebral type) were randomly divided into test control groups. Patients group manipulations, while those routine manipulations according to textbook of Chinese Massage for Acupuncture Moxibustion majors. The effects, symptoms, cerebral blood flow measured.The response was 100% 88.71% group....
Inflammation is a key factor in the development of moyamoya disease. However, cytokine distribution disease and its impact on prognosis remain unclear. A total 204 patients with were enrolled this study. The peripheral blood was analyzed for baseline data cytokines, which included IL-6, IL-1β, IL-2R, IL-8, TNF-α. Patients RNF213 mutation those without compared terms their differences cytokines. mRS score ≥2 defined as poor prognosis, <2 described good cytokines between two groups. Regression...
Liver transplantation is the definitive treatment for end-stage liver disease, yet T-cell mediated rejection (TCMR) remains a major challenge. This study aims to identify key genes associated with TCMR and their potential biological processes mechanisms. The GSE145780 dataset was subjected differential expression analysis, weighted gene co-expression network analysis (WGCNA), machine learning algorithms pinpoint TCMR. Gene Set Enrichment Analysis (GSEA), immune infiltration regulatory...
Background Non-alcoholic fatty liver disease (NAFLD) and chronic kidney (CKD) are both closely related to dyslipidemia. However, the relationship between dyslipidemia in patients with NAFLD CKD is not yet clear. The non-high-density lipoprotein cholesterol high-density ratio (NHHR) an innovative comprehensive lipid index. purpose of this study was investigate correlation NHHR risk or without fibrosis. Methods This used data from National Health Nutrition Examination Survey (NHANES) 2017 2020...
Abstract Objective To explore potential risk factors of preoperative cognitive dysfunction in adult patients with moyamoya disease (MMD) and discuss significance vessels. Methods The author reviewed MMD harboring no parenchymal infarction or hemorrhage underwent a standardized neuropsychological assessment test battery from December 2018 to May 2019. authors defined as impairment shown on 3 more tests. According the presence cerebral angiography, arterial stenosis, vessels, compensatory...