A5019998548- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disease Mechanisms and Treatments
- Coronary Interventions and Diagnostics
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Medical Imaging and Pathology Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Glaucoma and retinal disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Retinal Imaging and Analysis
- Cardiovascular Health and Disease Prevention
- Retinal and Optic Conditions
- Lung Cancer Treatments and Mutations
- Moyamoya disease diagnosis and treatment
- Medical Imaging Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
National Clinical Research Center for Digestive Diseases
2015-2025
Chinese Institute for Brain Research
2015-2025
China Rehabilitation Research Center
2019-2025
Hebei Medical University
2017-2025
Fourth Hospital of Hebei Medical University
2025
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2025
Chinese Center For Disease Control and Prevention
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations. Download PDF the Research Summary. We conducted multicenter, prospective, open-label, randomized trial China involving patients large-vessel occlusion anterior circulation and an Alberta Stroke Program Early Computed Tomography Score 3 to 5 (range, 0 10, lower values indicating larger infarction) or infarct-core volume 70 100 ml. Patients were randomly assigned...
<h3>Importance</h3> In-stent restenosis (ISR) is the primary reason for stroke recurrence after intracranial stenting in patients who were treated with a standard bare-metal stent (BMS). Whether drug-eluting (DES) could reduce risk of ISR atherosclerotic stenosis (ICAS) remains unclear. <h3>Objective</h3> To investigate whether DES can and symptomatic high-grade ICAS. <h3>Design, Settings, Participants</h3> A prospective, multicenter, open-label randomized clinical trial blinded outcome...
Objective To investigate the safety and efficacy of mechanical thrombectomy plus rescue therapy for intracranial large artery occlusion (ILAO) with underlying atherosclerosis (ICAS). Methods Patients enrolled in intervention group EAST (Endovascular Therapy Acute ischemic Stroke Trial) were analyzed. For ICAS identified during stent retrieval procedure, treatment was required those (1) a degree arterial stenosis >70% or (2) any blood flow impairment (3) evidence re-occlusion. Outcomes...
Background and Purpose: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice developing countries like China needs to be confirmed. aim the study was determine whether EVT acute ischemic stroke randomized trials could generalized Chinese population. Methods: We conducted a prospective registry at 111 centers China. Patients with caused by imaging-confirmed intracranial receiving were included. primary outcome functional independence 90 days defined as...
Importance Endovascular therapy (EVT) demonstrated better outcomes compared with medical management in recent randomized clinical trials (RCTs) of patients large infarct. Objective To compare EVT vs across different strata the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and infarct core volume Design, Setting, Participants This prespecified secondary analysis subgroups Therapy Acute Anterior Circulation Large Vessel Occlusive Patients With a Infarct Core (ANGEL-ASPECT)...
There were limited data on the long-term outcome of patients with symptomatic intracranial atherosclerotic stenosis ≥70% after Wingspan stenting. Using our cohort and from Warfarin Aspirin for Symptomatic Intracranial Atherosclerotic Disease (WASID) as a historical control, we tested hypothesis that stenting provided no benefit over antithrombotic therapy alone these high-risk patients.Between January 2007 February 2009, 100 consecutive symptoms within 90 days enrolled into this prospective...
<h3>BACKGROUND AND PURPOSE:</h3> Acute basilar occlusions have a poor prognosis without recanalization. Many underlying severe atherosclerotic intracranial stenosis coexisting with acute thrombosis, requiring treatment of both pathologies in the same session, though technical risks may be encountered. The purpose this study was to evaluate feasibility and safety combined by using stent retrievers for together angioplasty placement stenosis. <h3>MATERIALS METHODS:</h3> This retrospective...
Background and Purpose: A recent randomized controlled trial DIRECT-MT (Direct Intra-Arterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals) compared the safety efficacy of mechanical thrombectomy (MT) versus combined intravenous thrombolysis (IVT) MT for acute large vessel occlusion. The current study utilized a prospective, nationwide registry validate results real-world practice setting. Methods: Subjects were selected...
Background and purpose High periprocedural complication rate is a key limitation of endovascular treatment intracranial atherosclerotic disease (ICAD), despite potential risk reduction recurrent stroke. Taking lessons from the Stenting Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Arterial Stenosis (SAMMPRIS) trial, targeting selected patient population, we prospectively evaluated feasibility safety tailored angioplasty and/or stenting patients with ICAD....
EphB1, expressed in Müller cells, and ephrinB2, both cells retinal ganglion (RGCs), constitute an EphB/ephrinB reverse signaling RGCs. Whether how this is involved RGC apoptosis a rat chronic ocular hypertension (COH) model was investigated. In the COH model, EphB1 ephrinB2 were significantly increased activated, which accompanied by protein levels of phosphorylated (p) src, GluA2, p-GluA2. Intravitreal injection EphB2-Fc, activator induced increase TUNEL-positive signals normal retinae. A...
A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis (ICAS) combined poor collaterals in China showed that the short-term safety and efficacy was acceptable. However, it remained uncertain whether low event rate could be long term. We reported 1-year outcome this to evaluate long-term patients severe ICAS collaterals.Patients caused by 70%-99% located at internal carotid, middle cerebral, vertebral or...
To explore the CT characteristics of small lung nodules and improve diagnosis pulmonary ground-glass less than 10 mm in size.We retrospectively analyzed images 161 (less size) with spiculation, lobulation, vacuoles, pleural indentation compared these pathological results or follow-up images. The relationships between (GGNs) blood vessels were observed. GGN-vessel relationship was divided into four types, Type I (pass-by), II (pass-through), III (distorted/dilated), IV (complicated)....
Sex disparities in acute large vessel occlusion (LVO) following endovascular treatment (EVT) have been recently reported. However, there is uncertainty about the effect of sex differences on functional outcomes after EVT, particularly an Asian population. The present study aimed to compare clinical and safety between men women with anterior circulation LVO treated EVT.
OBJECTIVE The objective of this study was to investigate the incidence and predictors first-pass effect (FPE) compare clinical outcomes among FPE, multiple-pass effect, incomplete reperfusion (ICR) in acute anterior circulation large vessel occlusion. METHODS Patients from ANGEL-ACT (Endovascular Treatment Key Technique Emergency Workflow Improvement Acute Ischemic Stroke) registry were included. FPE defined as complete after a single pass thrombectomy device without rescue treatment. MPE ≥...
Some patients with large vessel occlusion (LVO) still cannot achieve functional independence despite successful reperfusion after endovascular treatment (EVT), named futile reperfusion. We aimed to explore the incidence and predictors of EVT for anterior circulation LVO in Chinese population based on a nationwide prospective multicenter registry.We selected from ANGEL-ACT (Endovascular Treatment Key Technique Emergency Workflow Improvement Acute Ischemic Stroke) registry. Successful was...
<b><i>Purpose:</i></b> Current studies on endovascular intervention for intracranial atherosclerosis select patients based luminal stenosis. Coronary demonstrated that fractional flow measurements assess ischemia better than anatomical stenosis and can guide patient selection intervention. We similarly postulated be used to ischemic stroke risk. <b><i>Methods:</i></b> This was a feasibility study the technical use safety of applying pressure...