A5032273680- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- RNA modifications and cancer
- Gene expression and cancer classification
- Extracellular vesicles in disease
- Intracranial Aneurysms: Treatment and Complications
- Molecular Biology Techniques and Applications
- Stroke Rehabilitation and Recovery
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Spinal Fractures and Fixation Techniques
- Vestibular and auditory disorders
- Connexins and lens biology
- Plant Molecular Biology Research
- Traditional Chinese Medicine Studies
- Mechanisms of cancer metastasis
- RNA Interference and Gene Delivery
- Healthcare and Venom Research
- UAV Applications and Optimization
- Hernia repair and management
Beijing Anzhen Hospital
2015-2025
Capital Medical University
2015-2025
Guangzhou Medical University Cancer Hospital
2025
Guangzhou Medical University
2025
Peking University
2014-2024
Nanjing Drum Tower Hospital
2021-2024
University of Pittsburgh Medical Center
2024
Air Force Medical University
2024
Liaoning Cancer Hospital & Institute
2014-2023
China Medical University
2017-2023
Reproducibility is a fundamental requirement in scientific experiments. Some recent publications have claimed that microarrays are unreliable because lists of differentially expressed genes (DEGs) not reproducible similar Meanwhile, new statistical methods for identifying DEGs continue to appear the literature. The resultant variety existing and emerging exacerbates confusion continuing debate microarray community on appropriate choice reliable DEG lists. Using data sets generated by...
Circular RNAs (circRNAs) are a novel class of endogenous noncoding formed by covalently closed loop, and increasing evidence has revealed that circRNAs play crucial functions in regulating gene expression. CircSLC8A1 is circRNA generated from the SLC8A1 gene. Currently, role underlying molecular mechanisms circSLC8A1 bladder cancer remain unknown.The differentially expressed were identified RNA-sequencing data, was determined as new candidate circRNA. qRT-PCR used to detect expression...
Background and Purpose: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice developing countries like China needs to be confirmed. aim the study was determine whether EVT acute ischemic stroke randomized trials could generalized Chinese population. Methods: We conducted a prospective registry at 111 centers China. Patients with caused by imaging-confirmed intracranial receiving were included. primary outcome functional independence 90 days defined as...
Abstract RNAi therapy has undergone two stages of development, direct injection synthetic siRNAs and delivery with artificial vehicles or conjugated ligands; both have not solved the problem efficient in vivo siRNA delivery. Here, we present a proof-of-principle strategy that reprogrammes host liver genetic circuits to synthesis self-assembly into secretory exosomes facilitate through circulating exosomes. By combination different circuit modules, assembled are systematically distributed...
Importance Endovascular therapy (EVT) demonstrated better outcomes compared with medical management in recent randomized clinical trials (RCTs) of patients large infarct. Objective To compare EVT vs across different strata the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and infarct core volume Design, Setting, Participants This prespecified secondary analysis subgroups Therapy Acute Anterior Circulation Large Vessel Occlusive Patients With a Infarct Core (ANGEL-ASPECT)...
Oxidative stress induced by reactive oxygen species (ROS) is associated with various neurological disorders including aging, neurodegenerative diseases, as well traumatic and ischemic insults. Astrocytes have an important role in the anti-oxidative defense brain. The gap junction protein connexin43 (Cx43) forms intercellular channels hemichannels astrocytes. In present study, we investigated contribution of Cx43 to astrocytic death ROS hydrogen peroxide (H2O2) mechanism which exerts its...
Survivin (encoded by the gene BIRC5) plays an important role in carcinogenesis of bladder cancer. Identifying miRNAs that target setting cancer will help to develop Survivin-based therapies for cancer.The expression levels miR-138-5p and protein were measured 12 resected specimens. The correlation between was further examined evaluating human cell lines either overexpressed or knocked down miR-138-5p. A luciferase reporter assay performed test direct binding BIRC5. We also investigated...
Long non-coding RNAs (lncRNAs) can regulate gene expression at different levels and are widely participate in various physiological pathological processes. Emerging evidences suggests that a number of differentially expressed lncRNAs involved tumorigenesis. However, the function regulation vast majority these unique is little known. Here, we found lncRNA Ras suppressor protein 1 pseudogene 2 (RSU1P2) upregulateded cervical cancer tissues has tumour-promoting role. We revealed RSU1P2 acts as...
Abstract MicroRNAs (miRNAs), a class of small noncoding RNAs that regulate target gene expression, play an important role in cancer initiation, progression, and metastasis. However, the many miRNAs cervical is not fully understood. In this study, we found miR‐212 miR‐132 from same cluster are downregulated human tissues when compared with adjacent noncancerous tissues. The overexpression miR‐212/132 only led to delay G1/S phase transition repressed cell proliferation but also resulted...
Exosomes are essential mediators of intercellular communication as they transport proteins and RNAs between cells. Owing to their tumor-targeting capacity, immune compatibility, low toxicity, long half-life, mesenchymal stem cell-derived exosomes have great potential for the development novel antitumor strategies. In this context, role produced by adipose-derived cells (ADSCs) treatment bladder cancer (BC) remains unclear. Here, we investigated use ADSCs a source therapeutic exosomes, well...
Plant genomes contain large numbers of duplicated genes that contribute to the evolution new functions. Following duplication, can exhibit divergence in their coding sequence and expression patterns. Changes cis-regulatory element landscape result changes gene High-throughput methods developed recently identify potential elements on a genome-wide scale. Here, we use recent comprehensive data set DNase I sequencing-identified binding sites (footprints) at single-base-pair resolution compare...
Early detection and effective prognosis prediction in patients with hepatocellular carcinoma (HCC) provides an avenue for survival improvement, yet more approaches are greatly needed. We sought to develop the models ultra-sensitivity low cost based on fragmentomic features of circulating cell free mtDNA (ccf-mtDNA).
Acute respiratory distress syndrome (ARDS) is one of the most organ dysfunctions in sepsis. Although development therapeutic strategies such as protective mechanical ventilation technology has improved mortality ARDS patients, there currently no effective drug for reducing associated mortality. Our study aims to investigate efficacy, safety, and pharmacoeconomics sivelestat sodium patients with septic ARDS, providing basis on clinical use this drug.This was a retrospective 140 ARDS. Clinical...
Background and Purpose: Studies on rescue therapy for acute posterior circulation stroke due to basilar artery occlusion (BAO) are limited in the modern era of mechanical thrombectomy (MT). The aim this study was evaluate safety efficacy stenting (RS) following MT failure patients with BAO. Methods: Data were collected from Endovascular Treatment Key Technique Emergency Work Flow Improvement Acute Ischemic Stroke (ANGEL-ACT) prospective registry China. Patients who underwent BAO...