A5101446322- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- RNA Research and Splicing
- interferon and immune responses
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Land Use and Ecosystem Services
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- Virus-based gene therapy research
- Advanced Computational Techniques and Applications
- Plant Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- AI and Multimedia in Education
Xinjiang University
2022-2024
China General Nuclear Power Corporation (China)
2024
Yueqing People's Hospital
2021-2024
South China Normal University
2022-2024
Chongqing Medical University
2012-2023
Shihezi University
2020-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Stanford University
2013-2022
Xintai People's Hospital
2022
Affiliated Hospital of Southwest Medical University
2022
The improvement of habitat quality is great significance to biodiversity conservation. Irrational development activities lead the degradation and loss biodiversity, especially in arid inland areas where ecological environment fragile. In this study, InVEST model used evaluate degree Ebinur Lake Basin from 1990 2020, while PLUS predict land use change under various scenarios. Combined with results zoning planning, spatial distribution inertia (ID) protection (EP) scenarios 2030 were compared...
MicroRNAs are emerging as important regulators of cancer-related processes. Our studies show that microRNA-9 (miR-9) is downregulated in human ovarian cancer relative to normal ovary, and overexpression miR-9 suppresses cell growth vitro. Furthermore, the 3'-UTR NF-kappaB1 mRNA found be regulated directly by miR-9, demonstrating a functionally target cells. When overexpressed cells, protein levels both suppressed, whereas inhibition results an increase expression level. Ovarian tissues...
MicroRNAs (miRNAs) are a new class of naturally occurring, small, non-coding RNAs that regulate protein-coding mRNAs by causing mRNA degradation or repressing translation. The roles miRNAs in lineage determination and proliferation, as well the localization several miRNA genes at sites translocation breakpoints deletions, have led to speculation could be important factors development maintenance neoplastic state.We showed miR-9 was downregulated human gastric adenocarcinoma. Overexpression...
MicroRNAs are a class of small noncoding RNAs that function as key regulators gene expression at the post-transcriptional level. In this study, we demonstrate miR-214 is frequently down-regulated in cervical cancer, and its reduces proliferation, migration, invasiveness cancer cells, whereas inhibiting results enhanced invasion. binds to 3'-UTR UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GALNT7), thereby repressing GALNT7 expression. Furthermore, first...
RAC1 regulates a diverse array of cellular events including migration and invasion. MicroRNAs (miRNAs) have key role in the regulation gene expression. In this study, we demonstrated that microRNA-142-3p (miR-142-3p) acted as negative regulator human RAC1. Overexpression miR-142-3p decreased mRNA protein levels. Moreover, overexpression suppressed, while blocking increased colony formation, invasion hepatocellular carcinoma (HCC) cell lines (QGY-7703 SMMC-7721). without 3′untranslated region...
Skin injury affects millions of people via the uncontrolled inflammation and infection. Many cellular components including fibroblasts signaling pathways such as transforming growth factor-β (TGF-β) were activated to facilitate wound healing repair injured tissues. C57BL/6 female mice divided into control ozone oil treated groups. Excisional wounds made on dorsal skin isolated from granulation The mouse model revealed that could significantly decrease area accelerate compared with group....
MiR‐214 has been shown to inhibit cell growth, migration and invasion. Here we demonstrate that ectopic expression of miR‐214 reduces survival, induces apoptosis enhances sensitivity cisplatin through directly inhibiting Bcl2l2 in cervical cancer HeLa C‐33A cells. Further analysis reveals induced by is correlated with increased Bax, caspase‐9, caspase‐8 caspase‐3. Moreover, show regulated DNA methylation histone deacetylation. Taken together, these data suggest might be a candidate target...
MicroRNAs (miRNAs) constitute a class of noncoding RNAs that post-transcriptionally regulate gene expression. Recent evidence indicates many miRNAs function as oncogenes or tumor suppressors by negatively regulating their target genes. In our previous study, using miRNA microarray analysis, we found miRNA-182 (miR-182) was significantly downregulated in human gastric adenocarcinoma tissue samples. Here, confirmed the downregulation miR-182 larger sample Overexpression suppressed...
Our study demonstrated the functions of microRNA‐7 (miR‐7) in cervical cancer. The overexpression miR‐7 cancer cell lines HeLa and C‐33A suppressed viability promoted apoptosis, whereas inhibition had opposite effects. Furthermore, an oncogene, X‐linked inhibitor apoptosis protein (XIAP), was identified as a new target miR‐7, ectopic expression XIAP rescued effects induced by cells. These results indicate that targeted downregulated oncogene to regulate effect on malignant behaviors
MicroRNAs (miRNAs) are a class of small, single-stranded, noncoding, functional RNAs. Hepatitis B virus (HBV) is an enveloped DNA with virions and subviral forms particles that lack core. It was not known whether HBV encodes miRNAs. Here, we identified HBV-encoded miRNA (called HBV-miR-3) by deep sequencing Northern blotting. HBV-miR-3 located at nucleotides (nt) 373 to 393 the genome generated from 3.5-kb, 2.4-kb, 2.1-kb in classic biogenesis (Drosha-Dicer-dependent) manner. highly...
Abstract MicroRNAs (miRNAs) have a critical role in tumorigenesis and metastasis, which are major obstacles of cancer therapy. However, the miRNAs colorectal (CRC) metastasis remains poorly understood. Here, we found that miRNA-10a (miR-10a) was upregulated primary CRC tissues cell line (SW480) derived from compared with metastatic lymph node (SW620). The differential expression miR-10a inversely correlated distant invasion depth. promoted migration vitro but inhibited vivo by regulating...
Emerging evidence has revealed that miRNAs could upregulate the expression levels of target genes. However, molecular mechanism underlying upregulation targets mediated by remains unclear. In this study, we found a novel miRNA named MIR-G-1 GRSF1-RNA immunoprecipitation (RIP)-deep sequencing, which directly and LMNB1 TMED5 in GRSF1-dependent manner cervical cancer cells. addition, upregulated promoted malignant phenotype vitro vivo. interact with WNT7B thus activated canonical...
Abstract MicroRNAs are a group of endogenously expressed, single‐stranded, 18–24 nt RNAs that regulate diverse cellular pathways. Although documented evidence indicates some microRNAs can function as oncogenes or tumor‐suppressors, the role miR‐214 in regulating human cervical cancer cells remains unexplored. We determined expression level and found it is downregulated compared with normal tissue. Overexpression HeLa cells, cell line, significantly inhibited proliferation according to MTT...
Chemotherapy is an important treatment for colorectal adenocarcinoma cancer; however, cells often develop resistance to chemotherapeutic drugs, leading relapse and poor patient prognosis. The development of drug a multifactor process, which involved several genes cellular mechanisms. microRNAs are endogenous small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In present study, we investigated possible role in regulating sensitivity SW620 SW480....