A5100624776- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Plant Molecular Biology Research
- RNA Research and Splicing
- RNA regulation and disease
- Tryptophan and brain disorders
- Genetic Mapping and Diversity in Plants and Animals
- Cutaneous Melanoma Detection and Management
- bioluminescence and chemiluminescence research
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Biomarkers in Disease Mechanisms
- Nuclear Receptors and Signaling
- Metabolomics and Mass Spectrometry Studies
- Transportation and Mobility Innovations
- Genomics, phytochemicals, and oxidative stress
- Cancer-related Molecular Pathways
- Electric Vehicles and Infrastructure
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Melanoma and MAPK Pathways
- Lipid metabolism and biosynthesis
Xiamen University
2024-2025
First Affiliated Hospital of Henan University of Science and Technology
2020-2025
Xuzhou Central Hospital
2024
Wuxi Vocational Institute of Commerce
2024
Zhejiang University
2017-2024
Zhejiang Ocean University
2024
Microsoft Research Asia (China)
2024
BGI Group (China)
2024
Tianjin Medical University
2011-2022
Chinese PLA General Hospital
2021-2022
Abstract Telomere shortening impairs liver regeneration in mice and is associated with cirrhosis formation humans chronic disease. In humans, telomerase mutations have been familial diseases leading to bone marrow failure or lung fibrosis. It currently unknown whether associate induced by The RNA component (TERC) the reverse transcriptase (TERT) were sequenced 1,121 individuals (521 patients disease 600 noncirrhosis controls). length was analyzed carrying gene mutations. Functional defects...
Emerging evidence has revealed that miRNAs could upregulate the expression levels of target genes. However, molecular mechanism underlying upregulation targets mediated by remains unclear. In this study, we found a novel miRNA named MIR-G-1 GRSF1-RNA immunoprecipitation (RIP)-deep sequencing, which directly and LMNB1 TMED5 in GRSF1-dependent manner cervical cancer cells. addition, upregulated promoted malignant phenotype vitro vivo. interact with WNT7B thus activated canonical...
Language models, such as GPT-3 and ChatGPT, demonstrate remarkable abilities to follow diverse human instructions perform a wide range of tasks, using instruction fine-tuning. However, when we test language models with basic table-understanding observe that today's are still sub-optimal in many table-related likely because they pre-trained predominantly on one-dimensional natural-language texts, whereas relational tables two-dimensional objects. In this work, propose new "\emphtable...
miRNAs typically downregulate the expression of target genes by binding to their 3'UTR, and dysregulation may contribute tumorigenesis. Here, we found that miR-346 miR-138 competitively bind a common region in 3'UTR hTERT mRNA have opposite effects on function human cervical cancer cells. Furthermore, G-rich RNA sequence factor 1 (GRSF1) mediates miR-346-dependent upregulation middle motif (CCGCAU) which forms "bulge loop" when is bound facilitating recruitment ribosomes promote translation...
As a major nutraceutical component of typical Mediterranean vegetable chicory, chicoric acid (CA) has been well-documented due to its excellent antioxidant and antiobesity bioactivities. In the current study, effects CA on lipopolysaccharide (LPS)-stimulated oxidative stress in BV-2 microglia C57BL/6J mice underlying molecular mechanisms were investigated. Results demonstrated that significantly reversed LPS-elicited cell viability decrease, mitochondrial dysfunction, activation NFκB MAPK...
MicroRNAs (miRNAs) are an evolutionarily conserved class of endogenous, non-coding RNAs that modulate gene expression at the post-transcriptional level and involved in tumorigenesis. In this study, we demonstrate miR-1 suppresses potential for growth, migration invasion HEp2 cell line. Furthermore, validate FN1 is a direct target via fluorescent reporter assay negatively regulated by miR-1. Moreover, knockdown has same phenotypic effects as overexpression Taken together, our results provide...
Summary Aims The predominant expression of aquaporin‐4 ( AQP 4) in the brain implies that this water channel may be involved a range disorders. This study was designed to investigate role 4 pathogenesis depression, and related possible biological mechanism. Methods Results Wild‐type +/+ ) knockout −/− mice were given daily subcutaneous injections corticosterone (20 mg/kg) for consecutive 21 days. Forced swimming test FST tail suspension TST showed longer immobility times...
In rapeseed, the oil content of seed not only supplies energy for germination and seedling development but also provides essential dietary nutrients humans livestock. Recent studies have revealed that many transcription factors (TFs) regulate accumulation fatty acids (FAs) during development. WRKY6, a WRKY6 family TF, was reported to serve function in plant senescence processes, pathogen defense mechanisms abiotic stress responses. However, precise role influencing FA seeds is still unknown....
Lipoic acid (LA) suppressed acrylamide (ACR)-induced inflammation, redox status disturbance, autophagy, and apoptosis mediated by mitochondria in the SH-SY5Y cells.
Large to giant congenital melanocytic nevi (LGCMN) present clinical challenges due their complex phenotypic heterogeneity and increased melanoma risk. Molecular-level research is essential for understanding the pathogenic mechanisms of...
Abstract Background Hepatitis B virus (HBV) plays a critical role in the tumorigenic behavior of human hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) have been reported to participate HCC development via regulation their target genes. However, HBV-modulated miRNAs involved tumorigenesis remain be identified. Here, we found that novel highly expressed miRNA, TLRC-m0008_3p (miR-3928v), may an important factor promotes malignancy HBV-related HCC. Methods Solexa sequencing was applied...
Lipoic acid (LA) ameliorated acrylamide (ACR)-induced social impairment in adolescent mice. reshaped gut microbiota and its metabolites. regulated serum amino level.
Isoalantolactone has recently been revealed to induce apoptosis in several types of cancer. However, little is reported on its anti-tumor potential human lung Our present study was designed investigate effects squamous carcinoma SK-MES-1 cells. We found that induced cellular and DNA morphological changes decreased the viability It significantly inhibited growth cells through a dose-dependent manner via activation p53. also cell cycle arrest at G1 phase. can down-regulate Bcl-2 up-regulate...
Costunolide is a sesquiterpene lactone, which possesses potent anti-cancer properties. However, there little report about its effects on esophageal cancer. In our study, we investigated the of costunolide cell viability, cycle, and apoptosis in human cancer Eca-109 cells. It was found that inhibited growth cells dose-dependent manner, associated with loss mitochondrial membrane potential (Δψm) production ROS. induced as well cycle arrest G1/S phase by upregulation P53 P21. triggered via Bax,...
Parkinson's disease (PD) is a common neurodegenerative disease, and the mechanism underlying PD pathogenesis not completely understood. Increasing evidence indicates that microRNAs (miRNAs) play critical regulatory role in of PD. This study aimed to explore miRNA-mRNA network for The differentially expressed miRNAs (DEmis) genes (DEGs) between patients healthy donors were screened from miRNA dataset GSE16658 mRNA GSE100054 downloaded Gene Expression Omnibus (GEO) database. Target DEmis...