A5083876116- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- Sexual function and dysfunction studies
- Structural Health Monitoring Techniques
- Hormonal and reproductive studies
- Prostate Cancer Treatment and Research
- Machine Fault Diagnosis Techniques
- Cancer-related gene regulation
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Liver Disease and Transplantation
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Fault Detection and Control Systems
- Hemodynamic Monitoring and Therapy
- Circular RNAs in diseases
- Heat shock proteins research
- Hepatitis C virus research
- BRCA gene mutations in cancer
- Extracellular vesicles in disease
Xiamen University
2025
University of Science and Technology of China
2025
Sinosteel (China)
2024
Temple University
2023
Jiangnan University
2020-2023
Wuxi Fourth People's Hospital
2020-2023
Fudan University
2013-2023
State Key Laboratory of Food Science and Technology
2022
Taizhou University
2022
Zhongshan Hospital
2022
Findings from observational studies indicate an association of thyroid hormone levels with the risk nonalcoholic fatty liver disease (NAFLD); however, conflicting results remain and reverse causality may be a possibility.This study aimed to evaluate associations between NAFLD both plasma thyroxine (T4) stimulating (TSH) at phenotypic genetic levels.We included 14 797 participants, aged 20 74 years who had undergone abdominal ultrasonography during Third National Health Nutrition Examination...
The prognosis and overall survival of castration-resistant prostate cancer (CRPC) patients are poor. search for novel efficient anti-CRPC agents is therefore extremely important. WM-3835 a cell-permeable, potent first-in-class HBO1 (KAT7 or MYST2) inhibitor. Here in primary human cells-derived from CRPC patients, potently inhibited cell viability, proliferation, cycle progression vitro migration. inhibitor provoked apoptosis the cells. It failed to induce significant cytotoxicity epithelial...
Estrogen signaling dysregulation plays a critical role in the development of anti-estrogen resistance and bone metastasis ER+ mammary carcinoma. Using quantitative proteomic screening, we identified FXR1 as an estrogen-regulated RNA-binding protein associated with resistance. Mechanistically, estrogen IGF1 facilitate translation via PI3K/AKT/mTOR/EIF4E pathway. enhances cellular to apoptosis ferroptosis by facilitating maturation BCL2 pre-mRNA stabilizing GPX4 mRNA, respectively....
Observational studies showed that low thyroid function may perturb liver function. We aimed to evaluate the association of with both metabolic dysfunction-associated fatty disease (MAFLD) and advanced hepatic fibrosis.Participants who underwent abdominal ultrasonography test in a Chinese hospital from 2015 2021were enrolled. Fibrosis-4 index (FIB-4) > 2.67 and/or non-alcoholic fibrosis score (NFS) 0.676 were used define fibrosis. Descriptive analyses performed characterize epidemiology MAFLD...
<title>Abstract</title> Background Identification of the tissue origin is fundamental for cancer treatment. However, squamous cell carcinomas from different sites lack representative histological and immunohistochemical features. This study aimed to identify mutational profiles further establish a DNA methylation-based classification carcinoma urothelial carcinoma. Samples unambiguous were collected targeted next-generation sequencing landscape analysis. Moreover, using Illumina methylation...
Reliability of the railway vehicle suspension system is critical importance to safety vehicle. It very desirable monitor health condition and performance degradation online, which offers important information critically for condition-based maintenance rather than scheduled in future. Advanced fault diagnosis method one most effective means monitoring system. In this paper, taking lateral as an examcple, isolation issue different component faults occurring concerned. The sensor configuration...
Increasing study have found that stem cell transplantation a therapeutical effect to diabetes mellitus (DM)-induced erectile dysfunction (ED). So, the aim of this was evaluate beneficial corin from adipose-derived cells (ADSCs) on DM-induced ED.Exosomes were isolated ADSCs (ADSC-EXOs) or in which gene expression silenced by siRNA (siCorin). For vivo studies, rats with streptozotocin-induced DM intravenously injected ADSC-EXOs siCorin-ADSC-EXOs. Two weeks later, intracavernosal pressure (ICP)...
Background: Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver diseases worldwide.There pressing clinical need to identify potential therapeutic targets for NASH treatment.Thioredoxin interacting protein (Txnip) stress responsive gene that has been implicated in the pathogenesis NASH, but its exact role not fully understood.Here, we investigated liver-and gene-specific Txnip and upstream/downstream signaling NASH.Methods Results: Using four independent mouse models,...
Background: Hypoxia was a common feature for accelerating tumor metastasis by both inducting epithelial-mesenchymal transition (EMT) of cells and polarization tumor-associated macrophages (TAMs).The association roles between hypoxia, EMT TAMs in the biological behavior gastric cancer (GC) time being recurrence is unclear.Material methods: hypoixa expression hypoxia-inducible factor-1 alpha (HIF-1α), polarized functional status infiltrated immunohistochemical staining CD68 CD163, E-cadherin...
Background and Aim: Aberrant sleep parameters are associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, existing information is inconsistent among studies involves reverse causation. Therefore, we aimed to investigate observational associations causations between traits NAFLD. Methods: We performed multivariable regression assess seven (sleep duration, easiness getting up in morning, chronotype, nap during day, snoring, insomnia, narcolepsy), NAFLD UK Biobank (1,029...
Anilin actin binding protein (ANLN) and transducing-like enhancer 2 (TLE2) are associated with cancer patient survival progression. The impact of their gene expression on progression-free (PFS) patients muscle invasive bladder (MIBC) treated radical cystectomy (RC) subtype association has not yet been investigated. qRT-PCR was used to measure the transcript levels ANLN TLE2 in Mannheim cohort, validated silico by Cancer Genome Atlas (TCGA) cohort. Uni- multivariate Cox regression analyses...
The insulin-like growth factor-1 receptor (IGF-1R) overexpression contributes to the development of a variety cancers. present study explored role IGF-1R in and progression hepatocellular carcinoma (HCC) possibility silencing by lentivirus-mediated RNA interference (RNAi) as therapeutic target for HCC. We showed that mRNA was up-regulated Huh7 Hep3B cells human HCC tissues, knockdown RNAi led decreased proliferation, apoptosis induction, migration invasion cells. Further, vivo indicated...
Kidney renal clear cell carcinoma (KIRC) is a subtype of that threatens human health. The mechanism by which the trophinin-associated protein (TROAP)-an important oncogenic factor-functions in KIRC has not been studied. This study investigated specific TROAP functions KIRC.
Abstract Background Growing evidence supports the pivotal role of long non-coding RNAs (lncRNAs) in regulation cancer development and progression. Their expression patterns biological function muscle invasive bladder (MIBC) remain elusive. Methods Transcript levels lncRNA miR-31 host gene ( MIR31HG ) its splice variants were measured our MIBC cohort n = 102) by qRT-PCR, validated silico TCGA 370). Kaplan-Meier multiple Cox regression analysis conducted to evaluate survival significance...
DNA repair genes (EG: xeroderma pigmentosum group D, XPD) may affect the capacity of encoded enzymes to effectively remove adducts or lesions, which result in enhanced cancer risk. The association between XPD gene polymorphisms and susceptibility prostate (PCa) was inconsistent previous studies.A meta-analysis based on 9 independent case-control studies involving 3165 PCa patients 3539 healthy controls for Gln751Lys SNP (single nucleotide polymorphism) 2555 cases 3182 Asn312Asp performed...
This study was aimed to analyze the potential role of Corin in procession diabetic ED and explore underlying mechanism. Diabetic rat model constructed characteristics control rats were recorded at 4, 8, 12, 16 weeks. qRT-PCR Western bloting used detected mRNA protein levels. Intracellular cGMP detection accomplished using a commercial radioimmunoassay method. Vascular endothelial cell from corpus cavernosum spiral artery isolated transfected with si- analyzed Corin. Cell viability assessed...
To describe the clinical parameters of urinary stones and investigate preoperative predictors sepsis in patients following percutaneous nephrolithotomy (PCNL). Patients Methods. A retrospective study who underwent PCNL between August 2017 December 2019 was performed. The were divided into nonsepsis groups according to whether they had sepsis, their data compared for further analysis.Fifteen (6.1%) matching age, gender, body mass index (BMI), number access variables included group....
3-D numerical simulations based on diffusion combustion technology were employed to optimize the multi-stage air/gas supply system in a coke oven battery with 7.1 m coking chambers. In heating flues, Eddy-Dissipation Concept (EDC) model and ideal gas utilized numerically investigate combustion. What is more, radiation between flue silicon brick was calculated using Discrete Ordinates (DO) model. After validating reliability of field-measured data, insights into temperature field flow flue,...