A5101418308- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Sirtuins and Resveratrol in Medicine
- Ion channel regulation and function
- Cardiovascular Disease and Adiposity
- Receptor Mechanisms and Signaling
- ECG Monitoring and Analysis
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Vitamin C and Antioxidants Research
- Cardiac Ischemia and Reperfusion
- Renal cell carcinoma treatment
- CRISPR and Genetic Engineering
- Heart Failure Treatment and Management
- Immune Cell Function and Interaction
- Carcinogens and Genotoxicity Assessment
- Vector-Borne Animal Diseases
- Behavioral Health and Interventions
- Bladder and Urothelial Cancer Treatments
- Cardiomyopathy and Myosin Studies
- Circadian rhythm and melatonin
Jiangsu Province Hospital
2008-2025
Nanjing Medical University
2009-2025
Changzhou No.2 People's Hospital
2012-2019
First Affiliated Hospital of Wannan Medical College
2010
Wannan Medical College
2010
Clinical parameters measured from gated single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) have value in predicting cardiac resynchronization therapy (CRT) patient outcomes, but still show limitations. The purpose of this study is to combine clinical variables, features electrocardiogram (ECG), and assessment function with polar maps SPECT MPI through deep learning (DL) predict CRT response. A total 218 patients who underwent rest-gated were enrolled study....
1. It has been well established that oestrogens can increase the number of endothelial progenitor cells (EPC) by anti-apoptotic effects. Resveratrol, a polyphenolic phytoalexin extracted from grapes and wine, reported to act as an oestrogen receptor agonist. We hypothesize putative phyto-oestrogen may promote EPC proliferation survival in vitro. 2. Endothelial were isolated human peripheral blood identified immunocytochemically. incubated with resveratrol (1, 10, 25 50 mmol/L) or control for...
Abstract To investigate whether resveratrol, a polyphenolic compound in red wine, affects the oxidation of human low density lipoprotein (LDL), LDL purified from normolipidemic subjects was subjected to Cu2+‐induced and azo compound‐initiated oxidative modification, with without addition varying concentrations resveratrol. Modification assessed by formation thiobarbituric acid reactive substances (TBARS) changes relative electrophoretic mobility‐(REM) on agarose gels. Resveratrol (50 μM)...
Abstract Introduction Polymorphisms of vascular endothelial growth factor ( VEGF ) gene were evaluated in a number studies to evaluate bladder cancer (BCa) susceptibility but with controversial conclusions. Material and Methods We performed pooled analysis used odds ratios (ORs) corresponding 95% confidence intervals (95% CIs) investigate the correlation between rs3025039C/T rs833052C/A variants risk BCa. Furthermore, we utilized silico tools demonstrate relationship expression correlated...
DNA repair genes (EG: xeroderma pigmentosum group D, XPD) may affect the capacity of encoded enzymes to effectively remove adducts or lesions, which result in enhanced cancer risk. The association between XPD gene polymorphisms and susceptibility prostate (PCa) was inconsistent previous studies.A meta-analysis based on 9 independent case-control studies involving 3165 PCa patients 3539 healthy controls for Gln751Lys SNP (single nucleotide polymorphism) 2555 cases 3182 Asn312Asp performed...
Pharmacological antiarrhythmic therapy such as beta-blockers in patients with frequent premature ventricular contractions (PVCs) and concomitant bradycardia is challenging. A traditional Chinese medicine, Shensong Yangxin (SSYX), has been effective treatment of PVCs sinus (SB) separate patient cohorts. This double-blind, placebo-controlled, multicentre, randomized clinical trial investigates the acute efficacy SSYX reducing burden SB. Patients symptomatic, PVCs, SB, defined mean heart rate...
Left ventricular noncompaction (LVNC) is an inherited cardiomyopathy involving numerous genes. To identify novel candidate causal mutations, a whole exome sequencing study was performed on Chinese LVNC family. Exons of the most prevalent pathogenic genes (myosin heavy chain 7 and actin, α‑cardiac muscle 1) were sequenced, although no mutations identified. Following this, Burrows‑Wheeler Aligner, PICARD Genome Analysis Toolkit (v.2.8) used to analyze data. Non‑silent single nucleotide...
SUMMARY Resveratrol, a polyphenol in red wine, has cardioprotective effect. Resveratrol‐targeting protein (RTP) been purified using resveratrol affinity column (RAC) and identified as quinone reductase type 2 (NQO2). We hypothesize that NQO2 is the target of vascular smooth muscle cells (VSMC) inhibits proliferation VSMC through its action on NQO2. In present study, we investigated correlation between regulation cell response to treatment. The RTP was RAC detected with polyclonal antibody....
1. The purpose of the present study was to explore relationship between electrocardiogram (ECG) patterns right ventricular outflow tract (RVOT) premature contractions and three-dimensional distribution target sites. 2. Thirty-three consecutive patients were included in study. sites identified by non-contact mapping confirmed successful ablation. reconstructed geometry RVOT classified three directions: (i) anterior (A)/posterior (P); (ii) free wall (F)/septal (Se); (iii) superior...
Human ether-à-go-go-related gene (hERG) potassium channels conduct the rapid component of delayed rectifier current (IKr), which is crucial for repolarization cardiac action potential. Patients with hERG‑associated long QT syndrome usually develop tachyarrhythmias during physical and/or emotional stress, both known to stimulate adrenergic receptors. The present study aimed investigate a putative functional link between β1-adrenergic stimulation and IKr in guinea-pig left ventricular myocytes...
Endogenous digitalis-like compound (EDLC) is an endogenous ligand of the digitalis receptor and can remarkably inhibit Na + /K -ATPase activity. Antidigoxin antiserum (ADA), a selective EDLC antagonist, may lessen myocardial reperfusion injury; however, molecular mechanisms underlying effect remain unclear. Therefore, this study investigated whether ADA prevent injury modulate gene expression sodium pump α isoforms. Cardiac function was examined in isolated rat hearts subjected to ischemia...
Background. The study was aimed at exploring the electrophysiological characteristics (EPS) of optimal ablation site and its relationship with electroanatomic voltage mapping (EVM) in idiopathic premature ventricular contractions (PVCs) originating from right outflow tract (RVOT). Methods. A total 28 patients RVOT PVCs underwent successful EVM using a 3D electroanatomical (CARTO) system. Results. Both bipolar unipolar showed similar band-like lower-voltage area (LVA) under pulmonary valve...
Objective To study the correlation between P53 Codon 72 Arg/Pro polymorphism and prostate cancer risk.Methods PubMed database was utilized to search articles relative association risk.All statistical analysis performed by STATA software.Results 1706 patients 2455 control subjects were included in meta-analysis.No observed overall (allelic contrast:P=0.406,OR=1.07,95％ CI:0.92-1.24; dominant genetic model:P=0.166,OR=1.05,95％ CI:0.98-1.13; recessive model:P=0.462,0R=0.87,95％...
Sleepiness affects normal social life, which attracts more and attention. Circadian phenotypes contribute to obvious individual differences in susceptibility sleepiness. We aimed identify candidate single nucleotide polymorphisms (SNPs) may cause circadian phenotypes, elucidate the potential mechanisms, generate corresponding SNP-gene-pathways. A genome-wide association studies (GWAS) dataset of was utilized study. Then, Identify Candidate Causal SNPs Pathways analysis employed GWAS after...
Objective To evaluate the efficacies of urethroscopic holmium YAG laser lithotripsy(ureteroscopy) and open ureterolithotomy for ureteral calculi more than 15 mm in diameter. Methods 110 patients with over diameter treated at our hospital from June, 2009 to 2017 were selected. 62 lithotripsy (URL group) 48 (OU group). The operative effect, operation time, bleeding volume, stay, complication, postoperative recovery investigated both groups. Results One patient URL group was...