A5051915881- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Bone Metabolism and Diseases
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Calcium Carbonate Crystallization and Inhibition
- Dental Implant Techniques and Outcomes
- Neurological Disease Mechanisms and Treatments
- Periodontal Regeneration and Treatments
- Endodontics and Root Canal Treatments
- interferon and immune responses
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Folate and B Vitamins Research
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Chemical Synthesis and Characterization
- Polymer Surface Interaction Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Meat and Animal Product Quality
- Osteoarthritis Treatment and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Ginkgo biloba and Cashew Applications
Guangdong Academy of Sciences
2020-2025
Shanghai Ocean University
2019-2025
Nantong University
2025
First Affiliated Hospital of Jinan University
2017-2024
Jiangsu Province Hospital
2021-2024
Jinan University
2017-2024
Nanjing Medical University
2014-2024
Zhongshan Hospital
2024
Fudan University
2014-2024
Xiangya Hospital Central South University
2024
The rapid development of nuclear energy posed a great threat to the environment and human health. Herein, two hydroxyl-functionalized hyper-crosslinked polymers (PIHCP-1 PIHCP-2) containing different electron active sites have been synthesized via Friedel-Crafts alkylation reaction polyimides. resulting showed micro/mesoporous morphology good thermal chemical stability. Rely on high porosity multi-active sites, PIHCPs show an ultrahigh iodine uptake capacity reached 6.73 g g−1 removal...
Abstract Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed embryo of lotus ( Nelumbo nucifera) exhibit potential anti-cancer activity. Here, we explored effects these on triple-negative breast cancer cells found that among three isoliensinine possesses most potent cytotoxic effect, primarily by inducing apoptosis. Interestingly, showed a much lower cytotoxicity against MCF-10A, normal human epithelial cell line. Further studies could significantly...
Continuous delivery of growth factors to the injury site is crucial creating a favorable microenvironment for cartilage repair. In present study, we fabricated novel sustained-release scaffold, stromal-derived factor-1α (SDF-1α)/transforming factor-β1 (TGF-β1)-loaded silk fibroin-porous gelatin scaffold (GSTS). GSTS persistently releases SDF-1α and TGF-β1, which enhance repair by facilitating cell homing chondrogenic differentiation. Scanning electron microscopy showed that porous...
Biphasic calcium phosphate (BCP) ceramics are valued for their osteoconductive properties but have limited osteogenic and angiogenic activities, which restricts clinical utility in bone defect repair. Silicon doping has emerged as an effective strategy to enhance these biological functions of BCP. However, the impact BCP is influenced by level silicon doping, necessitating determination optimal concentration maximize efficacy This study investigated effects on both physicochemical BCP, with...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with <5% five-year survival rate due to late diagnosis, limited treatment options and chemoresistance. There thus an urgent unmet clinical need develop effective anticancer drugs treat pancreatic cancer. Here, we study potential repurposing monensin as drug for chemo-resistant Using two commonly-used cancer cell lines PANC-1 MiaPaCa-2, show that suppresses proliferation migration, cycle progression, while solicits...
Abstract Minimizing the interaction of nanomedicines with mononuclear phagocytic system (MPS) is a critical challenge for their clinical translation. Conjugating polyethylene glycol (PEG) to regarded as an effective approach reducing sequestration by MPS. However, recent concerns about immunogenicity PEG highlight demand alternative low‐fouling polymers innovative coating materials nanoparticles. Herein, highly hydrophilic sulfoxide‐containing polymer—poly(2‐(methylsulfinyl)ethyl acrylate)...
Under consecutive monoculture, the abundance of pathogenic fungi, such as Fusarium oxysporum in rhizosphere Radix pseudostellariae , negatively affects yield and quality plant. Therefore, it is pertinent to explore role antagonistic fungi for management fungal pathogens F. oxysporum. Our PCR-denatured gradient gel electrophoresis (DGGE) results revealed that diversity Trichoderma spp. was significantly declined due extended monoculture. Similarly, quantitative PCR analysis showed a decline...
SrHA grown on GO nanosheet-reinforced chitosan scaffolds promoted the bone regeneration as and had good osteoconductivity high ALP activity while matrix played a role in antibacteria.
Although γ-secretase is recognized as a therapeutic target for Alzheimer's disease, side effects associated with strong inhibition of this aspartyl protease raised serious concerns regarding strategy. However, it not known whether moderate enzyme will allow dissociation beneficial in the CNS from mechanism-based toxicities periphery. We tested possibility by using series mice genetic reduction (levels ranging 25 to 64% control mice). Here, we document that even 30% can effectively ameliorate...
Head and neck squamous cell carcinoma (HNSCC) is one of the most common aggressive types human cancers worldwide. Nearly a half HNSCC patients experience recurrence within five years treatment develop resistance to chemotherapy. Thus, there an urgent clinical need safe novel anticancer therapies for HNSCC. Here, we investigate possibility repurposing anthelmintic drug mebendazole (MBZ) as anti-HNSCC agent. Using two commonly-used lines CAL27 SCC15, demonstrate MBZ exerts more potent...
microRNAs (miRNAs) act as regulatory signals for maintaining stemness, self-renewal, and differentiation of mesenchymal stem cells (MSCs), but whether miRNAs modulate the immunoregulatory function MSCs remains largely unknown. Here, we show that miR-21 negatively regulates activity cytokine transforming growth factor-β1 (TGF-β1) in MSCs. Consistently, bone marrow (BMMSCs) from miR-21(-/-) mice enhanced immunosuppressive by more TGF-β1 secretion induce CD4(+) Foxp3(+) T compared with...
Capsid-associated tegument proteins have been identified in alpha- and betaherpesviruses to play an essential role viral DNA packaging. Whether how such exist gammaherpesviruses mysteries. Here, we report a 6-Å-resolution cryo-electron microscopy (cryo-EM) structure of Kaposi's sarcoma-associated herpesvirus (KSHV) virion, member the oncogenic gammaherpesvirus subfamily. The KSHV virion reveals, for first time, capsid-associated are organized gammaherpesvirus, with five densities capping...