A5072184354- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Infection Control and Ventilation
- Advanced Sensor and Energy Harvesting Materials
- Air Quality and Health Impacts
- Bone health and osteoporosis research
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Conducting polymers and applications
- Climate Change and Health Impacts
- Medical Imaging and Pathology Studies
- Enzyme Production and Characterization
- Analytical Chemistry and Sensors
- SARS-CoV-2 detection and testing
- Microbial Natural Products and Biosynthesis
- High voltage insulation and dielectric phenomena
- Dental Research and COVID-19
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Neuroscience of respiration and sleep
- Dielectric materials and actuators
- Genetic Syndromes and Imprinting
- Global Health Care Issues
Peking Union Medical College Hospital
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Tongji University
2023-2024
Jiangsu Provincial Center for Disease Control and Prevention
2009-2023
Peking University
2021
State Key Laboratory of Respiratory Disease
2016-2019
Guangzhou Medical University
2016-2019
First Affiliated Hospital of Guangzhou Medical University
2019
Shanghai Jiao Tong University
2015-2018
Northwestern Polytechnic University
2008
Diagnostic delay of tumor induced osteomalacia (TIO) is common in clinic practice. To investigate the diagnostic condition TIO China and raise clinicians' awareness TIO, we retrospectively analyzed clinical manifestations, biochemical features, specially evaluated missed diagnoses misdiagnoses among 144 patients from Peking Union Medical College Hospital during December 1982 to 2014. Clinical presentations mainly included bone pain, difficulty walking, pathological fractures, muscle...
BackgroundIn COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise no special equipment, widely practiced in China becoming increasingly popular the rest of world. We hypothesized that Chi equivalent (ie, difference less than ±4 St. George's Respiratory Questionnaire [SGRQ] points) to PR.MethodsA total 120 patients (mean FEV1, 1.11 ± 0.42 L; 43.6% predicted)...
Abstract Background Respiratory and faecal aerosols play a suspected role in transmitting the SARS-CoV-2 virus. We performed extensive environmental sampling dedicated hospital building for Covid-19 patients both toilet non-toilet environments, analysed associated factors. Methods collected data of patients. 107 surface samples, 46 air two exhaled condensate expired samples were within beyond four three-bed isolation rooms. reviewed design cleaning routines. conducted field measurement...
ABSTRACT Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. It curable by excision of the causative tumor. However, few cases may persist or relapse after tumor resection. We aimed to investigate rate these events and related factors. retrospectively studied TIO patients treated with surgery in tertiary hospital. was established based on pathologic examination reversion hypophosphatemia. Refractory consisted those nonremission recurrent hypophosphatemia surgery. A total 230...
Exposure to extreme temperatures or fine particles is associated with adverse health outcomes but their interactive effects remain unclear. We aimed explore the interactions of and PM2.5 pollution on mortalities. Based daily mortality data collected during 2015-2019 in Jiangsu Province, China, we conducted generalized linear models distributed lag non-linear model estimate regional-level cold/hot extremes pollution. The relative excess risk due interaction (RERI) was evaluated represent...
Abstract Context Phosphate homeostasis was compromised in tumor-induced osteomalacia (TIO) due to increased fibroblast growth factor 23 (FGF23) secretion. Nevertheless, the glucose metabolic profile TIO patients has not been investigated. Objectives This work aimed clarify profiles and explore their interaction with impaired phosphate homeostasis. Methods 20 patients, individuals normal tolerance, type 2 diabetes mellitus (DM) were enrolled underwent an oral tolerance test (OGTT). Serum...
Objective Deep neck infection (DNI) associated with descending necrotizing mediastinitis (DNM) is a highly lethal condition. This retrospective review was performed to share our experience performing multidisciplinary management of DNI DNM during 7-year period. Methods We reviewed 16 patients who had been surgically treated for at Peking Union Medical College Hospital from April 2010 July 2017. The clinical outcomes were analysed determine the most appropriate therapeutic strategy. Results...
Ultrafine aluminum oxide, which are abundant in ambient and involved occupational environments, associated with neurobehavioral alterations. However, few studies have focused on the effect of sex differences following exposure to environmental Al2O3 ultrafine particles. In present study, male female mice were exposed nanoparticles (NPs) through a respiratory route. Only showed depression-like behavior. Although no obvious pathological changes observed brain tissues, neurotransmitter...
Airborne transmission of infectious diseases attracts great attention since the COVID-19 pandemic. Yet, there has been an intense dispute about aerosol disease, which is largely due to lack qualified instruments for studying subject. Air sampling plays a critical role in all air pollution related study, and particularly airborne pathogen detection. Here, we designed evaluated portable high volume (400 L min–1) cyclone sampler named as Yao-CSpler using aerosolized Polystyrene (PS) uniform...
Abstract Context Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) tumor. After successful tumor resection, patients can recover from hypophosphatemia quicky. However, data on the changes in bone mineral density (BMD) and microstructure short term after surgery remained unclear. Objective This work aimed to investigate postoperative BMD both peripheral axial TIO patients. Methods We evaluated...
ABSTRACT Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) tumor. Previous studies have revealed generalized mineralization defects and low areal bone mineral density (aBMD) in TIO. However, data on the microarchitecture TIO are limited. In this study, we evaluated peripheral (distal radius tibia) axial (lumbar spine) skeleton using high-resolution quantitative computed tomography (HR-pQCT) trabecular...
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23 (FGF23) production tumor, which often arises from mesenchymal origin.[1–3] Most clinical symptoms of TIO are the consequences prolonged FGF23-mediated hypophosphatemia as muscle weakness, bone pain, impaired mobility, and fractures.[4] Clinical diagnosis management challenging because knowledge about this condition still restricted to few specialized centers, leading delay in...
Probiotics could prevent Pseudomonas aeruginosa colonization in lower respiratory tract (LRT) and reduced P. ventilator-associated pneumonia (VAP) rate. Recent studies also suggested that probiotics improve lung inflammation mice infected with aeruginosa. It seems microbiota regulation may be a potential therapy for VAP patients. However, we know less about the LRT microbial composition its correlation prognosis This study aimed to characterize patients explore relationship between patient...
The COVID-19 pandemic has brought an unprecedented crisis to the global health sector1. When recovering patients are discharged in accordance with throat or nasal swab protocols using reverse transcription polymerase chain reaction (RT-PCR), potential risk of re-introducing infection source humans and environment must be resolved 2,3,4. Here we show that 20% patients, who were ready for a hospital discharge based on current guidelines, had SARS-CoV-2 their exhaled breath (~105 RNA...
ABSTRACT In children and adolescents, distinguishing tumor-induced rickets/osteomalacia (TIR/O) from hereditary hypophosphatemic (HR/O) is a medical challenge. We retrospectively studied 10 Chinese adolescents with TIR/O who underwent surgery at mean age of 17.4 ± 2.1 years compared their characteristics to 24 age- sex-matched patients X-linked hypophosphatemia (XLH). Positive family history HR/O dental problems, such as enamel hypoplasia abscess, were reported in 8 (33.3%) 5 (20.8%) XLX,...