A5005827885- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Cytokine Signaling Pathways and Interactions
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Colorectal Cancer Screening and Detection
- Malaria Research and Control
- Pharmacological Effects of Natural Compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Sleep and related disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obstructive Sleep Apnea Research
- COVID-19 and Mental Health
- Sepsis Diagnosis and Treatment
- Pancreatic function and diabetes
- Diabetes Management and Research
- Diet, Metabolism, and Disease
Institute of Plant and Microbial Biology, Academia Sinica
2025
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Fujian Medical University
2022-2025
Union Hospital
2022-2025
Jinshan Hospital of Fudan University
2025
Kunming Third People's Hospital
2016-2024
China Southern Power Grid (China)
2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Abstract COVID‐19 has developed into a worldwide pandemic; early identification of severe illness is critical for controlling it and improving the prognosis patients with limited medical resources. The present study aimed to analyze characteristics identify biomarkers differential diagnosis prediction. In total, 27 consecutive 75 flu were retrospectively enrolled. Clinical parameters collected from electronic records. disease course was divided four stages: initial, progression, peak,...
Introduction With intense deficiency of medical resources during COVID-19 pandemic, risk stratification is strategic importance. Blood glucose level an important factor for the prognosis infection and critically ill patients. We aimed to investigate prognostic value blood in patients with COVID-19. Research design methods collected clinical survival information 2041 consecutive hospitalized from two centers Wuhan. Patients without available were excluded. performed multivariable Cox...
Summary Background Although the outbreak of Coronavirus disease 2019 (COVID-19) has caused over 2200 deaths in China, there was no study about death yet. We aimed to describe clinical characteristics non-survivors with COVID-19. Methods For this retrospective, single-center study, we included 36 COVID-19 Fifth Hospital Wuhan. Cases were confirmed by real-time RT-PCR between Jan 21 and Feb 10, 2020 according recommended protocol. The epidemiological, demographic, clinical, laboratory,...
With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about risk to children with inflammatory bowel diseases (IBD). We aimed collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in era of COVID-19.An electronic reporting system infected SARS-CoV-2 has circulated among 102 PIBD centres affiliated Porto Interest-group ESPGHAN. A survey completed by major China South-Korea explore management during pandemic. third...
Abstract Purpose The incidence of early-onset colorectal cancer (EO-CRC), which occurs in people under age 50, has been increasing annually. aim this study was to provide an up-to-date estimate the global EO-CRC burden. Methods We used Global Burden Disease Study data and methodologies describe changes burden from 1990 2019, including incidence, prevalence, mortality, disability-adjusted life years (DALYs). driving factors for variation were further analyzed using decomposition analysis....
PURPOSE Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The controversy mainly regarding survival benefit from extended lymph node dissection emphasized by CME. METHODS This multicenter, open-label, randomized controlled trial (ClinicalTrials.gov identifier: NCT02619942 ) was performed across 17 hospitals in China....
Abstract Background Respiratory and faecal aerosols play a suspected role in transmitting the SARS-CoV-2 virus. We performed extensive environmental sampling dedicated hospital building for Covid-19 patients both toilet non-toilet environments, analysed associated factors. Methods collected data of patients. 107 surface samples, 46 air two exhaled condensate expired samples were within beyond four three-bed isolation rooms. reviewed design cleaning routines. conducted field measurement...
Background: Wutou Decoction (WTD), as a classic prescription, has been generally used to treat rheumatoid arthritis (RA) for two thousand years in China. However, the potential protective effects of WTD on and its possible mechanism have rarely reported. Purpose: The aim this study was explore against RA promising alternative candidate therapy. Methods: A model collagen-induced (CIA) constructed rats assess therapeutic WTD. Histopathological staining, immunofluorescence, western blotting...
Thousands of years clinical practice in the treatment joint-related diseases support efficacy and safety Wutou decoction (WTD). Nevertheless, lack pharmacological evidence unclear mechanisms make it difficult for WTD to become a recognized complementary therapy rheumatoid arthritis (RA).This study aimed investigate effect against synovial inflammation RA whether this depends on regulation macrophage polarization.Sprague-Dawley rats were used establish collagen-induced (CIA) model. with low...
Abstract Melanoma is one of the major cancer types for which new immune-based treatments have achieved promising results. However, anti–PD-1 and anti–CTLA-4 therapies are effective only in some patients. Hence, predictive molecular markers development clinical strategies targeting immune checkpoints needed. Using The Cancer Genome Atlas (TCGA) RNAseq data, we found that expression ESRP1, encoding a master splicing regulator epithelial–mesenchymal transition (EMT), was inversely correlated...
Abstract Hepatitis E virus (HEV) genotype 1 infection is common and can emerge as outbreaks in developing areas, thus posing a threat to public health. However, due the absence of feasible animal models, mechanism HE pathogenesis remains obscure. The HEV pathogenic has been suggested be mediated by immune system not direct viral duplication. We firstly discovered that open reading frame 3 (ORF3) protein downregulates TLR3-mediated NF-κB signaling Human A549 Lung Epithelial Cells (A549 cells)...
Abstract Background Systemic corticosteroids are now recommended in many treatment guidelines, although supporting evidence is limited to 1 randomized controlled clinical trial (RECOVERY). Objective To identify whether were beneficial COVID-19 patients. Methods A total of 1514 severe and 249 critical hospitalized patients from 2 medical centers Wuhan, China. Multivariable Cox models, model with time-varying exposure propensity score analysis (inverse-probability-of-treatment-weighting [IPTW]...