A5024316677- Plant Virus Research Studies
- Plant Disease Resistance and Genetics
- COVID-19 and healthcare impacts
- Colorectal Cancer Surgical Treatments
- Infection Control and Ventilation
- Plant and Fungal Interactions Research
- COVID-19 Clinical Research Studies
- Plant tissue culture and regeneration
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Potato Plant Research
- Plant-Microbe Interactions and Immunity
- Photosynthetic Processes and Mechanisms
- Plant Pathogenic Bacteria Studies
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Seed Germination and Physiology
- Plant Pathogens and Resistance
- Immune Cell Function and Interaction
- Intraperitoneal and Appendiceal Malignancies
- Magnetic and Electromagnetic Effects
- Plant Pathogens and Fungal Diseases
- Food Quality and Safety Studies
- Plant Molecular Biology Research
- Flowering Plant Growth and Cultivation
Hunan Agricultural University
2011-2025
Ruijin Hospital
2021-2023
Shanghai Jiao Tong University
2021-2023
People's Liberation Army No. 150 Hospital
2018-2021
PLA Academy of Military Science
2021
Chinese People's Liberation Army
2018-2021
Chinese PLA General Hospital
2020
Tri-Service General Hospital Songshan Branch
2020
Chinese General Hospital College of Nursing and Liberal Arts
2020
Nankai University
2016
PURPOSE Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The controversy mainly regarding survival benefit from extended lymph node dissection emphasized by CME. METHODS This multicenter, open-label, randomized controlled trial (ClinicalTrials.gov identifier: NCT02619942 ) was performed across 17 hospitals in China....
SUMMARY Plant viruses, constrained by their limited genomic coding capacity, rely significantly on host factors for successful infection. Disruption of these essential can confer resistance to with such categorized as susceptibility genes or recessive genes. Recent research has identified developmentally regulated plasma membrane polypeptide (DREPP) proteins integral the cell‐to‐cell movement potyviruses. In present study, we demonstrated that silencing StPCaP1 , a DREPP gene in potato,...
Potato (Solanum tuberosum L.) is the fourth most important crop worldwide. virus A (PVA) one of harmful viruses infecting potatoes. However, molecular mechanisms governing responses to PVA infection in potato at transcriptional and post-transcriptional levels are not well understood. In this study, we performed both mRNA small RNA sequencing leaves identify genes miRNAs involved response infection. total 2,062 differentially expressed (DEGs) 201 (DEMs) were identified, respectively. Gene...
Despite advances in identifying genetic factors of diabetic kidney disease (DKD), much the heritability remains unexplained. Nine maturity-onset diabetes young (MODY) probands with biopsy-proven DKD were selected and included this study. The had more severe compared their parents MODY, overt proteinuria or rapid progression to ESKD. We aimed explore contribution variants susceptibility genes severity phenotype between parents.Whole-exome sequencing was performed identify suspected MODY...
Abstract A previous study has identified two types of recombinant variants Potato virus Y strain NTN (PVY ) in China and sequenced the complete genome variant PVY -HN2. In this study, isolate -HN1 was fully analyzed. The most striking difference between location joint three (RJ3). -HN1, like other typical European-PVY isolates such as -Hun, RJ3 located at nucleotide (nt) 9183, namely 3' proximal end CP gene (nt. 8571-9371), thus leading to (the first 613 nucleotides from 5' end) (801 bp)...
Abstract Background The coronavirus disease 2019 (COVID-19) has been declared a global pandemic by the World Health Organization. Patients with cancer are more likely to incur poor clinical outcomes. Due prevailing pandemic, we propose some surgical strategies for gastric patients. Methods ‘COVID-19’ period was defined as occurring between 2020 and 01-20 2020-03-20. enrolled patients were divided into two groups, pre-COVID-19 group (PCG) COVID-19 (CG). A total of 109 in this study. Results...
Curvularia trifolii is an important pathogenic fungus that causes leaf spot disease in strawberry and other crops. Increased resistance fungi against chemical fungicides necessitates the search for biological alternatives to control plant fungal diseases. The present study aimed perform transcriptome metabolome analysis of C. fungi. We evaluated potential alkaloid, namely alpha (α)-solanine, inhibit growth under vitro conditions. Furthermore, transcriptomic metabolomic treated was performed...
Plant viruses recruit multiple host factors for translation, replication, and movement in the infection process. The loss-of-function mutation of susceptibility genes will lead to loss viruses, which is referred as 'recessive resistance'. Essential potexvirus Accumulation 1 (EXA1) has been identified a gene required potexvirus, lolavirus, bacterial oomycete pathogens. In this study, EXA1 knockdown potato (StEXA1) was found confer novel resistance virus Y (PVY, potyvirus) strain-specific...
Anthocyanin biosynthesis is affected by light, temperature, and other environmental factors. The regulation mode of light on anthocyanin synthesis in apple, pear, tomato species has been reported, while not clear potato. In this study, potato RM-210 tubers whose peel will turn purple gradually after exposure to were selected. Transcriptome analysis was performed during accumulation. expression StMYBA1 gene continued increase the accumulation tubers. Moreover, co-expression cluster...
Abstract Potato tubers exhibiting necrotic rings/arcs were found in a winter potato crop ‘Favorita’ the subtropical area Huidong county, Guangdong province, China, 2012. When symptomatic cut crosswise, light to dark brown arcs observed tuber flesh. A mini-survey of 8% an 10 meters2. To reveal causal agent disease, reverse transcription–polymerase chain reactions (RT-PCR) targeting 9 common viruses including those (e.g, mop-top virus (PMTV), Tobacco rattle virus, Tomato spotted wilt and Y...
Although adoptive cell therapy (ACT) has demonstrated effective and remarkable clinical responses in several studies, this approach does not lead to objective all cases. The function of ACT is often compromised by various tumor escape mechanisms, including the accumulation immunoregulatory cells. As a result peritoneal metastasis terminal stage, malignant ascites fluid lacks effectiveness poor prognostic factor for gastric cancer. present study assessed T-cell subsets lymphocytes derived...
The coronavirus disease 2019 is currently of global concern. Cancer patients are advised to stay at home in case potential infection, which may cause delays routine diagnosis and necessary treatment. How colorectal surgeons should manage this during the epidemic remains a big challenge. objective study evaluate feasibility surgery offer some Chinese recommendations throughout world.A total 166 receiving from 20 December March 2020 Department General Surgery Hospital People's Liberation Army...
Surgery is the most effective treatment for rectal cancer patients, but its key steps, including selection of level inferior mesenteric artery ligation and removal 253 lymph nodes, are still inconclusive. This study aimed to analyze effects different surgical methods, levels (low vs. high) node dissection areas (D2 D3) on short-term long-term outcomes.Between March 2014 August 2018, patients were retrospectively analyzed; 113 underwent low D2 (LLD2), 75 D3 (LLD3), 65 high (HL). We compared...
Due to their limited coding capacity, plant viruses have depend on various host factors for successful infection of the host. Loss function these will result in recessively inherited resistance, and therefore, are also described as susceptibility genes or recessive resistance genes. Most identified members eukaryotic translation initiation 4E family ( eIF4E ) its isoforms. Recently, an eIF4E-type gene, novel cap-binding protein nCBP ), was reported be associated with several encoding triple...
The complete genome comprising three genomic RNAs of Canadian and two Chinese isolates Potato mop-top virus were sequenced analysed. Two open reading frames (ORFs) found in RNA1 6.1 kb, encoding a readthrough RNA-dependent RNA polymerase (RdRp). A coat protein (CP)-readthrough was encoded by RNA2 3.1 kb. Four ORFs that the triple gene block proteins (TGBps) cysteine-rich RNA3 (2.9 kb) isolate 'Yunnan'; whereas remaining (three 'Guangdong'), only TGBps observed RNA3. single nucleotide...
Colorectal cancer (CRC) is one of the most common types gastrointestinal malignancy. Traditional therapeutic options for CRC exhibit a limited effect. Adoptive cellular therapy has emerged as new treatment strategy CRC. Dendritic cells (DCs) are potent antigen-presenting cells. Specific cytotoxic T lymphocytes (CTLs) activated by DCs pulsed with tumor lysate have been reported to be safe and promising approach However, antitumor effect specific CTLs remains limited. The low immunogenicity...
HSP40 (also known as DnaJ), HSP70, and HSP90 are major heat shock protein (HSP) families that play critical roles in plant growth development stress adaption. Recently, several members of the three HSP were reported to be widely involved host-virus interactions. However, their global expression profiles core recruited by viruses largely unknown. In this study, a total 89 StDnaJs identified from genome-wide survey, classification, phylogenetic relationships, chromosomal locations, gene...
To investigate CUE domain containing 2 ( CUEDC2) expression in colorectal cancer with different invasion and migration abilities.Fresh colon tissues, obtained from patients or without lymph node metastasis who were treated at the Department of General Surgery, Chinese People's Liberation Army Hospital, SW620 HT29 cell lines, analysed for CUEDC2 expression.Real-time polymerase chain reaction showed significantly higher mRNA levels tissue n = 8) versus metastasis, cells. Western blots revealed...