A5074884748- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Viral gastroenteritis research and epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Hernia repair and management
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Minimally Invasive Surgical Techniques
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Nutrition and Health in Aging
- Stoma care and complications
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Lipids, and Metabolism
- Amoebic Infections and Treatments
- Congenital Anomalies and Fetal Surgery
- Appendicitis Diagnosis and Management
- Pelvic and Acetabular Injuries
- Diverticular Disease and Complications
- Cancer Genomics and Diagnostics
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Peking University
2021-2023
Peking University Cancer Hospital
2021-2023
Anhui University of Science and Technology
2022
Soochow University
2008-2021
Jiangsu Provincial Center for Disease Control and Prevention
2021
Nanjing Medical University
2021
State Key Laboratory of Biotherapy
2019-2021
Nanjing University
2021
PURPOSE Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The controversy mainly regarding survival benefit from extended lymph node dissection emphasized by CME. METHODS This multicenter, open-label, randomized controlled trial (ClinicalTrials.gov identifier: NCT02619942 ) was performed across 17 hospitals in China....
Limited biomarkers have been identified as prognostic predictors for stage III colon cancer. To combat this shortfall, we developed a computer-aided approach which combing convolutional neural network with machine classifier to predict the prognosis of cancer from routinely haematoxylin and eosin (H&E) stained tissue slides. We trained model by using 101 cancers West China Hospital (WCH). The predictive effectivity was validated 67 WCH 47 Cancer Genome Atlas Colon Adenocarcinoma database....
Identification of dysregulated microRNAs (miRNAs) in prostate cancer is critical not only for diagnosis, but also differentiation between the aggressive and indolent forms disease. miR-9 was identified as an oncomiR through both miRNA panel RT-qPCR well high-throughput sequencing analysis human P69 cell line compared to its highly tumorigenic metastatic subline M12, found be consistently upregulated other lines including DU-145 PC3. While has been characterized either or tumour suppressor a...
tRNA-derived small RNAs (tsRNAs) are a class of novel RNAs, ubiquitously present in prokaryotes and eukaryotes. It has been reported that tsRNAs exhibit spatiotemporal expression patterns can function as regulatory molecules many biological processes. Current tsRNA databases only cover limited organisms ignore functional characteristics. Thus, integrating more relevant information is helpful for further exploration. Here, we database, named tsRBase, which integrates the pattern multiple...
Introduction The standard of care for stage III colon cancer is 3 or 6 months double-drug regimen chemotherapy following radical surgery. However, patients with positive circulating tumour DNA (ctDNA) exhibit a high risk recurrence even if they receive adjuvant chemotherapy. potential benefit intensified chemotherapy, oxaliplatin, irinotecan, leucovorin and fluoropyrimidine (FOLFOXIRI), ctDNA-positive remains to be elucidated. Methods analysis This multicentre phase II randomised controlled...
Survival prognosis is crucial for medical informatics. Practitioners often confront small-sized clinical data, especially cancer patient cases, which can be insufficient to induce useful patterns survival predictions. This study deals with small sample analysis by leveraging transfer learning, a machine learning technique that enhance the target related knowledge pre-learned from other data. We propose and develop various methods designed common models. For parametric models such as...
Rotaviruses cause acute diarrhea worldwide. Previous studies of rotavirus in China found that infection is the most common severe young children. In present study, surveillance was conducted involving 9549 children aged <5 years who were admitted for treatment at 11 sentinel hospitals from August 2003 through July 2007. Group A detected 3749 (47.8%) 7846 fecal specimens by using enzyme-linked immunosorbent assay. Rotavirus isolates characterized reverse-transcriptase polymerase chain...
Lymphocyte-to-monocyte ratio (LMR) was associated with survival benefit in some types of cancer. The relationship between LMR and rectal cancer has not been investigated. We conducted a retrospective cohort study to assess the prognostic significance patients nonmetastatic Patients who underwent potentially curative resection January 2009 December 2013 were enrolled. calculated from preoperative blood test by dividing absolute lymphocyte counts monocyte counts. optimal cut-off value for as...
Lateral lymph node (LLN) metastasis is a major cause of local recurrence advanced rectal cancer. Although there much controversy between Western and Eastern countries on whether lateral pelvic dissection (LLND) or neoadjuvant chemo-radiation (nCRT) preferable for the treatment LLN metastases, existing retrospective cohorts mainly focus all middle/low cancer patients, not specific individuals with suspicion metastases. The aim this trial to assess efficacy safety LLND patients This...
Several studies have reported that elevated red blood cell distribution width (RDW) was associated with the poor prognosis of different kinds cancers. The aim this study to investigate prognostic role RDW in patients undergoing resection for nonmetastatic rectal cancer. We retrospectively reviewed a database 625 consecutive who underwent curative cancer at our institution from January 2009 December 2014. cutoff value calculated by receiver-operating characteristic curve. results demonstrated...
Many assessment tools have been used to identify frail surgical patients. This study was designed explore the prediction value of frailty index (FI) for postoperative morbidity in older patients undergoing elective gastrointestinal surgery.Between January 2019 and September 2020, we conducted a prospective our hospital, aged over 65 years were enrolled. The FI by two specialist nurses based on 38-item scale, considered if score ≥ 0.25. primary outcome 30-day morbidity. Univariable...