A5037930685- Insect-Plant Interactions and Control
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Insect and Pesticide Research
- Immune Cell Function and Interaction
- Insect Resistance and Genetics
- Pharmacological Effects of Natural Compounds
- Bioinformatics and Genomic Networks
- Insect symbiosis and bacterial influences
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Actinomycetales infections and treatment
- Infectious Diseases and Mycology
- Yersinia bacterium, plague, ectoparasites research
- Hepatitis Viruses Studies and Epidemiology
- Metabolism, Diabetes, and Cancer
- Influenza Virus Research Studies
- Burkholderia infections and melioidosis
- Vector-borne infectious diseases
- Immune Response and Inflammation
- Healthcare and Venom Research
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Plant-based Medicinal Research
- Insect Pest Control Strategies
Tongji University
2019-2025
Shanghai Pulmonary Hospital
2019-2025
Shanghai Clinical Research Center
2020-2023
Chinese Academy of Agricultural Sciences
2020-2023
Institute of Plant Protection
2020-2023
Changzhi Medical College
2023
State Key Laboratory of Infectious Disease Prevention and Control
2014-2021
National Institute for Communicable Disease Control and Prevention
2014-2021
PLA Army Service Academy
2012-2017
Chengdu University
2016
Shexiang Baoxin Pill (SBP), a traditional Chinese medicine formula, is commonly used to treat cardiovascular disease (CVD) in China. However, the complexity of composition and targets has deterred our understanding its mechanism action. Using network pharmacology-based approaches, we established action for SBP CVD by analyzing protein-protein interactions pathways. The computational results were confirmed at gene expression level microarray-based studies. Two SBP's further protein Western...
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic progressive lung that increasing in incidence. Host genetic factors are associated with NTM-PD susceptibility. However, the heritability of not well understood. Here, we perform two-stage genome-wide association study (GWAS) and discover susceptibility locus at 16p21 NTM-PD, especially Mycobacterium avium complex (MAC) disease. As lead variant, rs194800 C allele augments protein kinase beta (PRKCB) gene expression...
Previous observational studies have reported protective effects of hand-washing in reducing upper respiratory infections, little is known about the associations between and good hygienic habits seasonal influenza infection. We conducted a case-control study to test whether risk transmission associated with self-reported unhealthy among residents Fujian Province, southeastern China. Laboratory confirmed cases were consecutively included as case-patients (n = 100). For each case, we selected 1...
Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly common. This retrospective cohort study examined factors associated with outcomes in patients from Shanghai who had NTM pulmonary disease (NTMPD) January 2014 to December 2018. The causative bacterial species, drug susceptibility test results, treatment outcomes, sputum culture conversion rate, and risk failure were determined. most common species Mycobacterium avium complex (MAC) (50%), M. abscessus (28%),...
To compare non-tuberculous mycobacterial pulmonary disease (NTMPD) diagnosis by metagenomic next-generation sequencing (mNGS) with Bactec growth indicator tube (MGIT) 960.A total of 422 patients suspected NTMPD in Shanghai Pulmonary Hospital between January 2020 and May 2021 were retrospectively analyzed; 194 diagnosed NTMPD. The diagnostic performance mNGS MGIT 960 for was assessed. Receiver operating characteristic (ROC) curves areas under curve (AUCs) compared.The sensitivity 81.4% higher...
The position of the chromatin opening Bemisia tabaci undergoes significant changes under different temperature stresses, and numerous regulatory factors have been found. In this study, we verified two key factors, cytochrome P450 4C1 carbonic anhydrase 3. results showed that invasive whiteflies had a significantly lower heat resistance after silencing BtCYP BtCar3. addition, higher cold tolerance 4C1. These indicate BtCar3 are regulators in adaptation B. tabaci. Moreover, they may be...
Mycobacterium tuberculosis (MTB) infection induces cytotoxicity tohost human macrophages.The underlying signaling mechanisms are largely unknown.Here we discovered that MTB induced programmed necrosis in macrophages, causing mitochondrial cyclophilin-D (CypD)-p53-adenine nucleotide translocator type 1 association, depolarization and lactate dehydrogenase medium release.In macrophages infection-induced apoptosis were attenuated by CypD inhibition (by cyclosporin A), silencing knockout, but...
Invasive species often encounter rapid environmental changes during invasions and only the individuals that successfully overcome stresses can colonize spread. Chromatin remodeling may be essential in adaptation. To assess functions of imitation switch (ISWI) invasive Bemisia tabaci Middle East–Asia Minor 1 (MEAM1) cryptic species, we cloned characterized MEAM1 BtISWI gene determined its response to thermal stress. The full-length cDNA was 3712 bp, with a 3068 bp open reading frame (ORF)...
Exposure to extreme temperatures can hinder the development of insects and even reduce their survival rate. However, invasive species Bemisia tabaci exhibits an impressive response different temperatures. This study aims identify important transcriptional changes B. occupying temperature habitats by performing RNA sequencing on populations originating from three regions China. The results showed that gene expression inhabiting with was altered identified 23 potential candidate genes respond...
Abstract Objective To evaluate the effectiveness and safety of linezolid-containing regimens for treatment M. abscessus pulmonary disease. Methods The records 336 patients with disease who were admitted to Shanghai Pulmonary Hospital from January 2018 December 2020 retrospectively analyzed. A total 164 received a regimen 172 controls did not. effectiveness, safety, antibiotic susceptibility profiles, outcomes, culture conversion, cavity closure, adverse reactions compared in these two...
It remains undefined whether a subset of CD4+ T cells can function as fast-acting to control Mycobacterium tuberculosis (Mtb) infection. Here we show that the primary CD4+CD161+ T-cell subset, not CD4+CD161-, in unexposed healthy humans fast acted unconventional capable inhibiting intracellular Mtb and BCG growth upon exposure infected autologous allogeneic macrophages or lung epithelial A549 cells. Such inhibition coincided with ability rapidly express/secrete anti-TB cytokines including...
Cytotoxic T lymphocytes (CTLs) play protective roles in immunity against tuberculosis (TB) infection by strongly inhibiting intracellular mycobacterial growth. In TB infection, the impairing mechanism of CTLs function remains unclear. this study, we identified that cytotoxic granule molecules expression levels perforin (PRF) and granulysin (GNLY) CD3+ CD8+ CTL cells were significantly depressed patients compared to those healthy donors. The frequencies T-CTLs, co-expressing granzyme B...
With increased focus on nontuberculous mycobacterial pulmonary disease (NTM-PD), and the improvement in detection methods, global incidence continues to increase every year, but diagnosis treatment are difficult with a high misdiagnosis rate poor curative effect. This study aimed analyze clinical indicators of different pathogenic NTM Yangtze River Delta. The retrospectively analyzed medical records patients NTM-PD, who resided Delta were diagnosed using sputum or bronchial lavage fluid...
Bemisia tabaci is an important invasive pest with worldwide distribution and strong temperature tolerance. Previous studies have shown that tolerance varies significantly between the different populations. Several key factors involved in epigenetic regulation been identified verified B. tabaci; therefore, adaptation mechanisms may also exist. This study aimed to detect changes chromatin accessibility landscape genome-wide transcriptome under stresses tabaci. Assay for transposase-accessible...
There were a total of 4 and 3 human plague cases that occurred in the Inner Mongolia Autonomous Region 2019 2020, respectively, with 1 2 deaths 2020 which indicated still poses significant threat to health especially for farmers, shepherds, or residents living native foci.On August 14, 2021, patient from Otog Qi (County) sought treatment Yinchuan City (the capital Ningxia Hui Region), where was diagnosed bubonic secondary septicemic plague. The genetic source tracking associated...
Insects are poikilothermic animals, and temperature is one of the most important abiotic factors affecting their spread distribution. For example, differences in thermal tolerance may underlie significant geographical distributions between native AsiaII3 invasive MED (Mediterranean) cryptic Bemisia tabaci species China. Transient receptor potential (TRP) channels key components insect perception system act as molecular thermometers since they can be activated by specific changes temperature....
Gene-gene association or protein-protein interaction databases have been important resource for the study of cellular functions and human diseases. A number gene available in public domain. Each these has its own unique virtues, but no single database could provide enough confidence coverage. These years some meta-databases built by integrating various resources functional associations weighing evidence each score systems. In this work, we compared three weighted genome-scale networks...
In clinical practice at Tibetan area of China, Traditional Medicine formula Wuwei-Ganlu-Yaoyu-Keli(WGYK) is widely added in warm water bath therapy to treat rheumatoid arthritis (RA). However, its action mechanism not well interpreted yet. this study, based on gene expression data from microarray experiments, we apply approaches network pharmacology further reveal the that WGYK exerts RA perspective protein-protein interactions and pathways. This study may facilitate our understanding...