A5060548792- Viral gastroenteritis research and epidemiology
- Helicobacter pylori-related gastroenterology studies
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Respiratory viral infections research
- Eosinophilic Esophagitis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Antimicrobial Resistance in Staphylococcus
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Digestive system and related health
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Virus-based gene therapy research
- Food Allergy and Anaphylaxis Research
- Mosquito-borne diseases and control
- Clinical Nutrition and Gastroenterology
- Animal Disease Management and Epidemiology
- Immune Response and Inflammation
- Gastroesophageal reflux and treatments
Guangzhou Medical University
2016-2025
Nanyang Technological University
2024
First Affiliated Hospital of Jinan University
2015-2024
Southern Medical University
2024
Institut Pasteur of Shanghai
2019-2023
Guangzhou Women and Children Medical Center
2014-2023
Guiyang Medical University
2023
Chinese Academy of Sciences
2022
Wuhan Institute of Virology
2022
Sun Yat-sen University
2014-2021
Cow's milk is the most common cause of food-protein-induced enterocolitis syndrome (FPIES). The aim this study was to examine clinical features and treatment outcomes infants with severe FPIES cow's milk. We reviewed all ≤ 12 months age who were hospitalized diagnosed between 1 January 2011 31 August 2014 in a tertiary Children's Medical Center China. Patients' features, feeding patterns, laboratory tests, reviewed. A total met inclusion criteria. All presented diarrhea, edema,...
Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 required for tumor cell migration, invasion and apoptosis. However, the functional role of in regulating associated macrophages (TAMs) polarization colon cancer has never been reported. expression human tissues was examined with immunohistochemistry (IHC). M1/M2 macrophage signatures were evaluated by RT-PCR, IHC flow cytometry. The effects on growth TAM investigated both vitro vivo. targeted cytokines/pathway...
Aberrant expression of microRNA (miR)-1 has been observed in many human malignancies. However, the function and underlying mechanism miR-1 remains elusive. To address specific role tumor glycolysis using gain- or loss-of-function studies. Metabolic studies combined with gene analysis were performed vitro vivo. We demonstrated aberrant aerobic glycolysis, Warburg effect, cancer cells. MiR-1 suppressed cell proliferation via inactivation Smad3 targeting HIF-1α, leading to reduce HK2 MCT4...
Pancreatic carcinoma (PC) is one of the most aggressive cancers affecting human health. It essential to identify candidate biomarkers for diagnosis and prognosis PC. The present study aimed investigate PC.Differentially expressed genes (DEGs) were identified from mRNA expression profiles GSE62452, GSE28735 GSE16515. Functional analysis protein-protein interaction network was performed explore biological function DEGs. Diagnosis markers PC using ROC curve analysis. Prognosis via survival TCGA...
Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation inflammation and impaired intestinal barrier function. However, the function MCs in IBD remains be fully elucidated.In our study, we used exosomes isolated from human mast cells-1 (HMCs-1) culture with NCM460, HT-29 or CaCO2 epithelial (IECs) investigate communication between IECs. We MCs-derived significantly increased permeability destroyed...
Uncontrolled inflammation occurred in sepsis results multiple organ injuries and shock, which contributes to the death of patients with sepsis. However, regulatory mechanisms that restrict excessive are still elusive. Here, we identified an Ig-like receptor called signaling lymphocyte activation molecular family 7 (SLAMF7) as a key suppressor during We found expression SLAMF7 on monocytes/macrophages was significantly elevated septic mice. attenuated TLR-dependent MAPK NF-κB macrophages by...
Abstract A variety of intracellular bacteria modulate the host cytoskeleton to establish subcellular niches for replication. However, role intermediate filaments, which are crucial mechanical strength and resilience cell, in bacterial vacuole preservation remains unclear. Here, we show that Salmonella effector SopB reorganizes vimentin network form cage-like structures surround -containing vacuoles (SCVs). Genetic removal markedly disrupts SCV organization, significantly reduces replication...
Astragalus membranaceus is a Chinese medicinal herb and has been shown to improve hapten-induced experimental colitis. One of its major components polysaccharides. We investigated the effect polysaccharides (APS) on expression TNF-α, IL-1β NFATc4 in rat model colitis.The colitis was induced by TNBS. Forty five rats were divided into groups (n=9): Normal control group, receiving ethanol vehicle with no TNBS during induction IP saline injection treatment; group (TNBS+IP saline), only APS low...
Abstract Macrophages play a crucial role in host innate anti-mycobacterial defense, which is tightly regulated by multiple factors, including microRNAs. Our previous study showed that panel of microRNAs was markedly up-regulated macrophages upon mycobacterial infection. Here, we investigated the biological function miR-146a during expression induced both vitro and vivo after Mycobacterium bovis BCG The inducible could suppress nitric oxide (NO) synthase (iNOS) NO generation, thus promoting...
Abstract Objective Inflammatory bowel disease (IBD) is a disorder intestinal inflammation and impaired barrier function, associated with increased epithelial expression of monocarboxylate transporter 4 (MCT4). However, the specific non‐metabolic function clinical relevance MCT4 in IBD remain to be fully elucidated. Methods Lentivirus‐mediated overexpression was used assess role transcriptionally regulating ZO‐1 IL‐6 by luciferase assays, WB ChIP. IP analyse effect on interaction NF‐κB‐CBP or...
Background Limited research has been published on current Helicobacter pylori infection rate in asymptomatic children China. Aim To assess rate, distribution characteristics and risk factors Chinese children. Methods A prospective, cross-sectional, population-based study was performed from 2009 to 2011 three cities of diagnosed by a stool antigen test. Multi-stage cluster random sampling used select including neonates. Socioeconomic details were obtained through standardised questionnaire....
Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and axonal elongation. However, whether how CRMPs associate with microtubules actin coordinated cytoskeletal remain unknown. In this study, we demonstrated CRMP2 CRMP4 interacted tubulin vitro colocalized cytoskeleton transition-zone cones. also one...
Idiopathic central precocious puberty (ICPP) is a common disease in preadolescence girls, and its pathogenesis remains to be uncovered. A variety of studies highlighted the association gut microbiota (GM) with endocrine diseases, such as obesity, which complication ICPP. However, relationship between GM ICPP unexplored. Feces samples were collected from 25 girls (ICPP group) 23 healthy (Control group). We applied 16S rDNA sequencing compare two groups. The group had higher diversity was...
<p indent="0mm">Chronic renal failure (CRF) is a severe syndrome affecting the urinary system for which there are no effective therapeutics. In this study, we investigate effects and mechanisms of aminophylline in preventing CRF development. A rat model chronic established by 5/6 nephrectomy. The levels serum creatinine (SCR), protein (UPR), blood urea nitrogen (BUN) detected ELISA. Histological evaluations tissues performed H&E, Masson staining, PAS staining. Functional expression...
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of anti-mitocondrial autoantibodies (AMA) which has essential role also for diagnosis. In addition, some anti-nuclear antibodies (ANA) have been shown to be highly specific PBC. The purpose this study was assess prevalence PBC among adults referring hospital annual health check-up in Southern China screening sera PBC-specific autoantibodies.AMA and ANA were screened 8,126 (mean age 44 ± 15 years, 48%...
Helicobacter pylori infection is a major risk factor for chronic gastritis, digestive ulcers, gastric adenocarcinoma and lymphoma. Due to the decreasing efficacy of anti-H. antibiotic therapy in clinical practice, there renewed interest development vaccines. Bacillus subtilis non-pathogenic can produce endospores, which survive under extreme conditions. These features make B. spore an ideal vehicle delivery heterologous antigens environments such as gastrointestinal tract. In this study, we...
In recent years, enterovirus D68 (EVD68) has been reported increasingly to be associated with severe respiratory tract infections and acute flaccid myelitis (AFM) in children all over the world. Yet, no effective vaccines or antiviral drugs are currently available for EVD68. Although several experimental animal models have developed, immunogenicity protective efficacy of inactivated EVD68 not fully evaluated. To promote development vaccines, we established an Institute Cancer Research (ICR)...
Abstract Background : Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence CMPA Chinese infants. The aim this population‐based study to determine prevalence, clinical characteristics, and outcome Methods We carried out a prospective survey 7 participating hospitals throughout southern China. included infants ≤12 months age during survey. For those suspected CMPA, oral food challenge with cow's (CMP) was performed. A follow‐up...
Zika virus (ZIKV) is a newly emerging flavivirus that broadly exhibits in various bodily tissues and fluids, especially the brain, ZIKV infection often causes microcephaly. Previous studies have been reported can infect renal cells be detected urine samples of infected individuals. However, whether diseases its pathogenic mechanisms remains unknown. Here, we identified resulted acute kidney injury (AKI) both newborn adult mouse models by increasing levels AKI-related biomarkers [e.g., serum...
Limited understanding of T cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impeded vaccine development and drug discovery for disease 2019 (COVID-19). We found that triggering receptor expressed on myeloid cells (TREM-2) was induced in the blood lungs patients with COVID-19. After binding to SARS-CoV-2 membrane (M) protein through its immunoglobulin domain, TREM-2 then activated CD3ζ/ZAP70 complex, leading STAT1 phosphorylation T-bet transcription. In...