A5000809621- Aldose Reductase and Taurine
- Antiplatelet Therapy and Cardiovascular Diseases
- Kawasaki Disease and Coronary Complications
- Heme Oxygenase-1 and Carbon Monoxide
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Cardiovascular Issues in Pregnancy
- Cardiac Ischemia and Reperfusion
- Extracellular vesicles in disease
- Blood Coagulation and Thrombosis Mechanisms
- Inflammasome and immune disorders
- Cannabis and Cannabinoid Research
- Mast cells and histamine
- Coronary Artery Anomalies
- Wnt/β-catenin signaling in development and cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related gene regulation
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Infectious Aortic and Vascular Conditions
- Kruppel-like factors research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacology and Obesity Treatment
- Ion Channels and Receptors
- Vasculitis and related conditions
City University of Hong Kong
2022-2024
Guangzhou Medical University
2016-2024
Third Affiliated Hospital of Zhengzhou University
2022-2024
Sun Yat-sen University
2020
Yale University
2011-2016
Cardiovascular Research Center
2015
Beijing Normal University - Hong Kong Baptist University United International College
2011
University of Hong Kong
2007-2010
Smooth muscle cells (SMCs) are remarkably plastic. Their reversible differentiation is required for growth and wound healing but also contributes to pathologies such as atherosclerosis restenosis. Although key regulators of the SMC phenotype, including myocardin (MYOCD) KLF4, have been identified, a unifying epigenetic mechanism that confers has not reported.Using human SMCs, arterial tissue, mouse models, we report plasticity governed by DNA-modifying enzyme ten-eleven translocation-2...
Background: Aberrant expression of circular RNA contributes to human diseases. Circular RNAs regulate gene by sequestering specific microRNAs. In this study, we investigated whether circMAP3K5 (circular mitogen-activated protein kinase 5) could act as a competing endogenous microRNA-22-3p (miR-22-3p) sponge and neointimal hyperplasia. Methods: profiling from genome-wide sequencing data was compared between coronary artery smooth muscle cells (SMCs) treated with or without platelet-derived...
Diabetes mellitus is associated with platelet hyperactivity, which leads to increased morbidity and mortality from cardiovascular disease. This coupled enhanced levels of thromboxane (TX), an eicosanoid that facilitates aggregation. Although intensely studied, the mechanism underlying relationship among hyperglycemia, TX generation, hyperactivity remains unclear. We sought identify key signaling components connect high glucose generation examine their clinical relevance. In human platelets,...
Research Article24 May 2016Open Access Source DataTransparent process Inducing mitophagy in diabetic platelets protects against severe oxidative stress Seung Hee Lee Section of Cardiovascular Medicine, Department Internal Yale Center, University School New Haven, CT, USA Search for more papers by this author Jing Du Jeremiah Stitham Gourg Atteya Suho Departments Neurology and Neurobiology, Cellular Neuroscience, Neurodegeneration Repair Program, Yaozu Xiang Dandan Wang Yu Jin Kristen L...
Background— Platelet abnormalities are well-recognized complications of diabetes mellitus. Mitochondria play a central role in platelet metabolism and activation. Mitochondrial dysfunction is evident The molecular pathway for hyperglycemia-induced mitochondrial platelets mellitus unknown. Methods Results— Using both human humanized mouse models, we report that aldose reductase activation subsequent reactive oxygen species production lead to increased p53 phosphorylation (Ser15), which...
Upon arterial injury, endothelial denudation leads to platelet activation and delivery of multiple agents (e.g., TXA2, PDGF), promoting VSMC dedifferentiation proliferation (intimal hyperplasia) during injury repair. The process resolution vessel repair, prevention excessive repair (switching VSMCs back a differentiated quiescent state), is poorly understood. We now report that internalization APs by promotes switching on quiescence. Ex vivo in studies using lineage tracing reporter mice...
Kawasaki disease (KD) is an acute vasculitis of early childhood that can result in permanent coronary artery structural damage. The cause for this arterial vulnerability up to 15% patients with KD unknown. Vascular smooth muscle cell dedifferentiation play a key role the pathophysiology medial damage and aneurysm formation, recognized pathology KD. Platelet hyperreactivity also hallmark We recently demonstrated uptake platelets platelet-derived miRNAs influences vascular phenotype vivo.
Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of mechanisms underlying AAA development and progression. ATF3 (activating transcription factor 3) has been increasingly recognized as key regulator cardiovascular diseases. However, role in progression remains elusive.
Hyperglycemia is an indication of poor outcome for heart attack patients, even nondiabetic patients with stress-induced hyperglycemia. Previous studies showed that inhibition aldose reductase, the first and rate-limiting enzyme polyol pathway, attenuated contractile dysfunction in diabetic animals, but mechanism unclear. We therefore wanted to find out whether pathway also contributes acute hyperglycemia-induced cardiac dysfunction, determine involved. Rat hearts were isolated retrogradely...
Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation osmotic stress by regulating the transcription genes responsible synthesis or transport organic osmolytes. It also play a role in immune function, myogenesis and cancer invasion. To better understand function NFAT5, we developed NFAT5 gene knockout mice. Homozygous null (NFAT5−/−) mouse embryos failed develop normally died after 14.5 days embryonic development (E14.5). The showed...
Platelet is an anucleate cell containing abundant messenger RNAs and microRNAs (miRNAs), their functional roles in hemostasis inflammation remain elusive. Accumulating evidence has suggested that platelets can actively transfer to hepatocytes, vascular cells, macrophages, tumor cells. The incorporated mRNAs are translated into proteins, miRNAs were found regulate the gene expression, resulting change of recipient This novel intercellular communication opens up a new avenue for...
According to previous studies, inhibition of the canonical Wnt signaling pathway promotes regeneration zebrafish heart, and treatment injured heart tissue with activator BIO impairs cardiomyocyte proliferation. However, mechanism by which regulates downstream gene expression following injury remains unknown. Here, injury-induced myocardial wnt2bb jnk1/creb1/c-jun repair after apex resection. The jnk1, creb1 c-jun is decreased in hearts expressing a dominant negative mutant increased...
Abstract Kawasaki disease (KD) is a severe acute febrile illness and systemic vasculitis that causes coronary artery aneurysms in young children. Platelet hyperreactivity an aberrant immune response are key indicators of KD; however, the mechanism by which hyperactive platelets contribute to inflammation vasculopathy KD remains unclear. A cytokine‐mediated positive feedback loop between monocytes identified. platelet–monocyte aggregates (MPAs) mediated initial interaction P‐selectin (cluster...