A5104273343- Liver Disease Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Hepatitis B Virus Studies
- High-Energy Particle Collisions Research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Spine and Intervertebral Disc Pathology
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Immune cells in cancer
- HIV Research and Treatment
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV/AIDS drug development and treatment
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Protease and Inhibitor Mechanisms
- Diet and metabolism studies
Nanjing Medical University
2021-2025
Capital Medical University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
Jining First People's Hospital
2019-2025
Zhengzhou University
2023-2025
Xijing Hospital
2025
Hunan Cancer Hospital
2023-2025
Central South University
2023-2025
Air Force Medical University
2013-2025
Rationale: Apolipoprotein E (apoE) exerts anti-inflammatory properties that protect against atherosclerosis and other inflammatory diseases. However, mechanisms by which apoE suppresses the cellular activation of leukocytes commonly associated with remain incompletely understood. Objective: To test hypothesis inflammation regulating microRNA levels in these leukocytes. Methods Results: An assessment expression among such leukocyte subsets wild-type mice revealed only macrophages monocytes...
Background: Aberrant expression of circular RNA contributes to human diseases. Circular RNAs regulate gene by sequestering specific microRNAs. In this study, we investigated whether circMAP3K5 (circular mitogen-activated protein kinase 5) could act as a competing endogenous microRNA-22-3p (miR-22-3p) sponge and neointimal hyperplasia. Methods: profiling from genome-wide sequencing data was compared between coronary artery smooth muscle cells (SMCs) treated with or without platelet-derived...
Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles head neck squamous cell carcinoma (HNSCC) remain largely uncharacterized. Here, we sought investigate function mechanisms transfer RNA (tRNA) N7-methylguanosine (m7 G) modification regulating occurrence development HNSCC.Cell lost-of-function gain-of-function assays,...
Interplay between innate and adaptive immune cells is important for the antitumor response. However, tumor microenvironment may turn suppressive, associated macrophages are playing a role in this transition. Here, we show that CD276, expressed on tumor-associated (TAM), play diminishing response against tumors. Using model of tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine BLCA male mice genetic ablation CD276 TAMs blocks efferocytosis enhances expression major histocompatibility...
The Notch pathway regulates the development of many tissues and cell types is involved in a variety human diseases, making it an attractive potential therapeutic target. This promise has been limited by absence potent inhibitors or agonists that are specific for individual receptors (NOTCH1-4). Using unbiased functional screening, we identified monoclonal antibodies specifically inhibit induce activating proteolytic cleavages NOTCH3. Remarkably, most inhibitory bind to overlapping epitopes...
Abstract This study mainly investigated the neurotoxicity induced by zinc oxide nanoparticle (ZnO NP) in different-aged mice and interaction between age ZnO NP exposure. Sixty adult old male C57BL/6J were assigned to four groups based on a two-factor (age exposure) design. Results showed that NPs (5.6 mg/kg, intraperitoneal) increased production of pro-inflammatory cytokines serum brain mice. A synergistic reaction aging exposure occurred regarding interleukin 1 (IL-1) 6 (IL-6). In brain,...
To study the regulatory relationship between ozone-induced mitophagy and pyroptosis in lung epithelial cells.First, type I primary alveolar cells male Wistar rats were treated with ozone at different dosages. The ATP content mitochondrial membrane potential significantly decreased cells. mitophagy-related markers PINK1/Parkin pathway-related proteins, co-localization of LC3, Parkin, mitochondria indicated that exposure triggered mitophagy. On other hand, reactive oxygen species (ROS)...
Purpose The childhood hand, foot and mouth disease (HFMD) sequelae cohort study (HNHFMDCS) is an ambispective of patients with HFMD based in Henan Province, China, consisting treated a key hospital for the diagnosis treatment Province. aims to investigate long-term survivors provide comprehensive understanding potential harm caused by this infectious disease. Participants In retrospective phase study, children diagnosed from January 2014 2023 were included, clinical demographic information...
Glucose is the principle energy source for mammalian brain. Delivery of glucose from blood to brain requires its transport across endothelial cells blood-brain barrier and plasma membranes neurons glia, which mediated by facilitative transporter proteins. The two primary isoforms function in cerebral metabolism are GLUT1 GLUT3. barrier, choroid plexus, ependyma, glia; GLUT3 neuronal transporter. levels expression both transporters regulated concert with metabolic demand regional rates...
The most abundant cellular divalent cations, Mg
Meiosis is a highly sophisticated process, in which transcriptional regulations play critical role. However, the mechanism of transcriptome changes during meiosis, especially prophase I, has been poorly studied. Here we performed single-cell ATACseq human testis and found reprogramming process at transition from zygotene to pachytene spermatocytes. Conserved mice, genes that functioned meiosis were deactivated after while spermatogenesis activated before their functions. Furthermore,...
Resistin, a novel adipocytokine, has been suggested as representing link between metabolic signals, inflammation and atherosclerosis. The aim of the present study was to investigate alteration in level plasma resistin patients with acute coronary syndrome (ACS) uncover role resistin.The 39 ACS 26 age-matched healthy subjects this cross-sectional were investigated. Plasma levels measured using radioimmunoassay. significantly increased at 24 h after symptoms onset remained high for 1 week,...
Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevention many years. However, the mechanism by which GLP exerts its chemopreventive activities remains elusive. In addition, it is unclear whether sporoderm-broken spores of G. water extract (BSGLWE), contains mainly GLPs, has anticancer effects on colorectal cancer. The present study investigated and potential mechanisms BSGLWE in vivo vitro. Our results showed that...
To assess the association between Hounsfield units (HU) measurement and cage subsidence after lumbar interbody fusion.Transforaminal fusion (TLIF) with unilateral fixation becomes a popular treatment modality for degenerative disease. Cage is potentially devastating complication fixation. Recently, new technique assessing bone mineral density using HU values from computed tomography has been proposed. Bone quality believed to be one of important factors that cause TLIF.Cage single-level...