A5032320809- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
- Phytochemicals and Antioxidant Activities
- Retinal and Optic Conditions
- Cardiomyopathy and Myosin Studies
- Biochemical Analysis and Sensing Techniques
- Diversity and Career in Medicine
- Advanced Chemical Sensor Technologies
- Circadian rhythm and melatonin
- Ion channel regulation and function
- Viral Infections and Immunology Research
- Olfactory and Sensory Function Studies
- Postharvest Quality and Shelf Life Management
- Calcium signaling and nucleotide metabolism
- Magnesium in Health and Disease
- Ophthalmology and Visual Health Research
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Effects of Exercise
Western University
2018-2022
Stromal interaction molecule 1 (STIM1) is an endo/sarcoplasmic reticulum (ER/SR) calcium (Ca2+) sensing protein that regulates store-operated entry (SOCE). In SOCE, STIM1 activates Orai1-composed Ca2+ channels in the plasma membrane (PM) after ER stored depletion. S-Glutathionylation of at Cys56 evokes constitutive SOCE DT40 cells; however, structural and biophysical mechanisms underlying regulation by this modification are poorly defined. By establishing a protocol for site-specific...
Stromal interaction molecule-1 and -2 (STIM1/2) are endoplasmic reticulum (ER) membrane-inserted calcium (Ca2+) sensing proteins that, together with Orai1-composed Ca2+ channels on the plasma membrane (PM), regulate intracellular levels. Recent evidence suggests that S-nitrosylation of luminal STIM1 Cys residues inhibits store operated entry (SOCE). However, effects thiol modifications STIM2 during nitrosative stress their role in regulating basal levels remain unknown. Here, we demonstrate...
To outline the current impact of Canadian ophthalmology and vision science research as measured by novel metrics.Cross-sectional survey.All ophthalmologists (n = 687) scientists 119) with an online bibliometric profile academic appointment at a major training centre were included.Faculty lists Canada's 15 departments obtained. Faculty names, appointments, sex, educational background recorded. Elsevier's Scopus database was used to calculate H-index, m-quotient, total citations for each...