A5101437385- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Cancer-related gene regulation
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Salivary Gland Disorders and Functions
- Phagocytosis and Immune Regulation
- Bone and Dental Protein Studies
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Structural Integrity and Reliability Analysis
- Hippo pathway signaling and YAP/TAZ
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
- Effects of Radiation Exposure
- Viral-associated cancers and disorders
- Renal and related cancers
- Lymphoma Diagnosis and Treatment
Sun Yat-sen University
2021-2025
Stomatology Hospital
2021-2025
Sun Yat-sen Memorial Hospital
2025
Hospital of Stomatology, Sun Yat-sen University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Institute of Precision Mechanics
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Peking Union Medical College Hospital
2017
Interplay between innate and adaptive immune cells is important for the antitumor response. However, tumor microenvironment may turn suppressive, associated macrophages are playing a role in this transition. Here, we show that CD276, expressed on tumor-associated (TAM), play diminishing response against tumors. Using model of tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine BLCA male mice genetic ablation CD276 TAMs blocks efferocytosis enhances expression major histocompatibility...
Background CD276 (B7-H3), a pivotal immune checkpoint, facilitates tumorigenicity, invasiveness, and metastasis by escaping surveillance in variety of tumors; however, the underlying mechanisms facilitating escape esophageal squamous cell carcinoma (ESCC) remain enigmatic. Methods We investigated expression ESCC tissues from patients using immunohistochemistry (IHC) assays. In vivo, we established 4-nitroquinoline 1-oxide (4NQO)-induced knockout (CD276 wKO ) K14cre; conditional cKO mouse...
Ameloblastoma (AM), a common odontogenic epithelial tumor, exhibits aggressive growth due to incomplete encapsulation within the jawbone. Postoperative recurrence is significant concern, closely associated with its invasive nature. We investigate role of tRNA N-7 methylguanosine (m
Abstract Head and neck squamous cell carcinoma (HNSCC) is characterized by high recurrence or distant metastases rate the prognosis challenging. There mounting evidence that tumor-infiltrating B cells (TIL-Bs) have a crucial, synergistic role in tumor control. However, little known about TIL-Bs play immune microenvironment way affect outcome of checkpoint blockade. Using single-cell RNA sequencing (scRNA-seq) data from Gene Expression Omnibus (GEO) database, study identified distinct gene...
Abstract Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone destruction and high recurrence rate. However, the mechanisms governing initiation are poorly understood. Here, we uncovered cellular landscapes that underlie in ameloblastoma at single-cell resolution. Our results revealed exhibits five subpopulations varying with respect immune response (IR), remodeling (BR), tooth development (TD), epithelial (ED), cell cycle (CC) signatures. Of...
RNA N6-methyladenosine is a key step of posttranscriptional modulation that involved in governing gene expression. The m 6 A modification catalyzed by Mettl3 has been widely recognized as critical epigenetic regulation process for tumorigenic properties various cancer cell lines, including bladder cancer. However, the vivo function remains largely unknown. In our study, we found ablation urothelial attenuates oncogenesis and tumor angiogenesis using transgenic mouse model. addition,...
PCIF1 can mediate the methylation of N6,2'-O-dimethyladenosine (m6Am) in mRNA. Yet, detailed interplay between and potential cofactors its pathological significance remain elusive. Here, we demonstrated that PCIF1-mediated cap mRNA m6Am modification promoted head neck squamous cell carcinoma progression both vitro vivo. CTBP2 was identified as a cofactor to catalyze deposition on CLIP-Seq data bound similar mRNAs compared with PCIF1. We then used m6Am-Seq method profile site at single-base...
Mutations modification enzymes including the tRNA N
Abstract Tumor budding (TB) is a small tumor cell cluster with highly aggressive behavior located ahead of the invasive front. However, molecular and biological characteristics TB regulatory mechanisms governing phenotypes remain unclear. This study reveals that exhibits particular dynamic gene signature stemness partial epithelial‐mesenchymal transition (p‐EMT). Importantly, nuclear expression CYTOR identified to be key regulator p‐EMT phenotype cells, targeting significantly inhibits...
BET inhibition has been shown to have a promising antitumor effect in multiple tumors. However, the impact of on immunity was still not well documented HNSCC. In this study, we aim assess functional role and clarify its mechanism. We show that BRD4 is highly expressed HNSCC inversely correlated with infiltration CD8+ T cells. potentiates cell-based vitro vivo. Mechanistically, acts as transcriptional suppressor represses expression MHC class I molecules by recruiting G9a. Pharmacological or...
Tumor-initiating cells (TICs) play a key role in cancer progression and immune escape. However, how TICs evade elimination remains poorly characterized. Combining single-cell RNA sequencing (scRNA-seq), dual-recombinase-based lineage tracing, other approaches, we identified WNT-activated subpopulation of malignant that act as vivo. We found intensive reciprocal interactions between regulatory tumor-associated macrophages (Reg-TAMs) via GAS6-AXL/MERTK signaling pathways, which facilitated the...
Blending hydrogen into existing natural gas pipelines can cause embrittlement, which further leads to pipeline leakage and even serious explosions. Therefore, a mathematical-physical model is established for the of hydrogen-blended (HBNG) based on species transport in this paper. The validated by experimental values from literature, with validation errors falling below 15%. influence different operating structural parameters analyzed rate HBNG. results show that decreases blending ratio...
Pleomorphic adenoma (PA) is the most common benign tumour in salivary gland and has high morphological complexity. However, origin intratumoral heterogeneity of PA are largely unknown. Here, we constructed a comprehensive atlas at single-cell resolution showed that exhibited five subpopulations, three recapitulating epithelial states normal parotid gland, two PA-specific cell (PASE) populations unique to tumours. Then, six subgroups PASE cells were identified, which varied epithelium, bone,...
FOSL1, a key component of the Activating protein-1 (AP-1) transcriptional complex, plays an important role in cancer cell migration, invasion, and proliferation. However, impact FOSL1 ameloblastoma (AM) has not been clarified. Herein, we aimed to assess expression investigate its functional AM.The was examined based on immunohistochemistry analysis 96 AM samples. Cell proliferation, tumorigenesis were assessed using Counting Kit-8 (CCK-8), colony formation, Transwell, sphere formation...
Pancreatic ductal adenocarcinoma is a most deadly malignancy, with 5-year survival rate of ~7%.Chemotherapy the main treatment strategy this disease.However, high resistance to chemotherapeutic agent contributes poor prognosis.MicroRNAs are essential for initiation, progression and chemoresistance human malignancies.Previous studies have shown that miRNA-1285 participates in renal cell carcinoma hepatocellular carcinoma.However, its roles pancreatic poorly understood.In study, we confirmed...
Abstract Background Radiation-induced lung injury (RILI) is considered one of the most common complications thoracic radiation. Recent studies have focused on stem cell properties to obtain ideal therapeutic effects, and Sox9 has been reported be involved in induction differentiation. However, whether Sox9-expressing cells play a role radiation repair regeneration remains unknown. Methods We successfully obtained CreER , Rosa tdTomato DTA mice identified through lineage tracing. Then, we...
Radiotherapy for head and neck cancer can cause serious side effects, including severe damage to the salivary glands, resulting in symptoms such as xerostomia, dental caries, oral infection. Because of lack long-term treatment current research has focused on finding endogenous stem cells that differentiate into various cell lineages replace lost tissues restore functions. Here, we report Sox9+ epithelial under homeostatic conditions. After ablating cells, glands irradiated mice showed more...
MiR-21-5p is one of the most common oncogenic miRNAs that upregulated in many solid cancers by inhibiting its target genes at posttranscriptional level. However, upstream regulatory mechanisms miR-21-5p are still not well documented cancers. Here, we identify a super-enhancer associated with MIR21 gene (MIR21-SE) analyzing genomic landscape head and neck squamous cell carcinoma (HNSCC). We show MIR21-SE regulates expression different HNSCC lines disruption inhibits expression. also...
Tertiary lymphoid structures have been observed in several solid tumors and suggested to be a favorable prognostic factor. However, the value of tertiary for early clinical stage (cT1/2N0) oral tongue squamous cell carcinoma (OTSCC) remains unclear. In this study, we aimed evaluate cT1/2N0 OTSCC.Ninety-seven patients with OTSCC were enrolled study. assessed paraffin sections H.E immunohistochemistry staining. Overall disease-free survivals evaluated by Kaplan-Meier method. Cox proportional...
Abstract Methyltransferase like 13 (METTL13), a kind of methyltransferase, is implicated in protein binding and synthesis. The upregulation METTL13 has been reported variety tumors. However, little was known about its potential function head neck squamous cell carcinoma (HNSCC) so far. In this study, we found that significantly upregulated HNSCC at both mRNA level. Increased negatively associated with clinical prognosis. And markedly affected cellular phenotypes vivo vitro. Further mechanism...
Abstract Objective Head and neck squamous cell carcinoma (HNSCC) is the most common type of malignancy in head region worldwide. The therapeutic strategies for HNSCC remain unsatisfying limited. Here, we found a population resistant Bmi1‐expressing cells presence cetuximab treatment reported novel role SRY‐box transcription factor 18 (SOX18), member SOX family, promoting resistance to cetuximab. This study aimed investigate regulatory mechanism Sox18 Bmi1‐positive search better targets....
Tumor-infiltrating immune cells (TIICs) are critical components of tumor microenvironment (TIME), which play crucial roles during initiation, development, and progression. However, the prognostic value TIICs is still not well documented in clinical early-stage oral squamous cell carcinoma (OSCC). In this study, we aimed to assess OSCC develop a nomogram based on predict prognosis.Eighty patients with (cT1,2N0M0) were enrolled study. Immunohistochemical staining was performed evaluate...