A5101859488- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Climate variability and models
- Meteorological Phenomena and Simulations
- Lung Cancer Treatments and Mutations
- Tropical and Extratropical Cyclones Research
- BRCA gene mutations in cancer
- Precipitation Measurement and Analysis
- Nutrition, Genetics, and Disease
- Erythrocyte Function and Pathophysiology
- Cardiac Fibrosis and Remodeling
- Hydrological Forecasting Using AI
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- GDF15 and Related Biomarkers
- Cardiac Arrhythmias and Treatments
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Herbal Medicine Research Studies
- Connexins and lens biology
- Diabetes and associated disorders
Sichuan University
2023-2025
State Key Laboratory of Biotherapy
2025
Zhongshan Hospital
2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
First Affiliated Hospital of Anhui Medical University
2014-2024
Anhui Medical University
2014-2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
West China Hospital of Sichuan University
2023
Mis-regulated epigenetic modifications in RNAs are associated with human cancers. The transfer (tRNAs) the most heavily modified RNA species cells; however, little is known about functions of tRNA In this study, we uncovered that expression levels N7-methylguanosine (m7G) methyltransferase complex components methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) significantly elevated lung cancer samples negatively patient prognosis. Impaired m7G modification upon METTL1/WDR4...
Abstract Mis-regulated RNA modifications promote the processing and translation of oncogenic mRNAs to facilitate cancer progression, while molecular mechanisms remain unclear. Here we reveal that tRNA m 7 G methyltransferase complex proteins METTL1 WDR4 are significantly up-regulated in esophageal squamous cell carcinoma (ESCC) tissues associated with poor ESCC prognosis. In addition, progression via activity vitro vivo. Mechanistically, or knockdown leads decreased expression G-modified...
Mutations modification enzymes including the tRNA N
Abstract Background Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. Despite existing therapy approaches, 5-year event-free survival (EFS) patients advanced NBL remains below 30%, emphasizing urgent necessary novel therapeutic strategies. Studies have shown that epigenetic disorders play an essential role pathogenesis of NBL. However, function mechanism...
Objective To screen feature genes of heart failure patients through machine learning methods, in order to identify characteristic driving and investigate the progression Methods Heart patient samples were downloaded from public database GEO (Gene Expression Omnibus), including datasets GSE116250, GSE120895, GSE59867. GSE116250 GSE120895 used as testing set, while GSE59867 was validation set. LASSO regression analysis SVM-RFE utilized genes. Results Analysis showed that among differentially...
Objective Exploring the effect of SJQJD on pulmonary microbiota chronic obstructive disease (COPD) rats through 16S ribosomal RNA (rRNA) sequencing. Methods A COPD rat model was constructed smoking and lipopolysaccharide (LPS) stimulation, efficacy evaluated by hematoxylin eosin (H&E) staining Enzyme-Linked Immunosorbnent Assay (ELISA). The alveolar lavage fluid subjected to rRNA diversity lung composition community structure analyzed differential were screened. Additionally, machine...
To analyse the genotypes of clinical isolates Extended-Spectrum-β-Lactamase-Producing (ESBL-producing) Proteus mirabilis (P. mirabilis) and mechanisms antimicrobial resistance, to guide reasonable use antibiotics avoid nosocomial outbreak infections by ESBL-producing P. mirabilis. 125 were collected from Drug-Resistant Bacteria Surveillance Center Anhui Province (from Jan 2009 May 2010). Searching for ESBLs was perfomed PCR amplification DNA sequencing, performed conjugation test...
A nonlinear statistical ensemble prediction modeling method has been developed for predicting monthly mean rainfall using Particle Swarm Optimization (PSO) algorithm and neural network (NN) technique. Comparison results of experiments show that the PSO-NN (PNNEP) model is superior to traditional linear forecast in capability. Computation analysis PNNEP also demonstrate integrates predictions dozens members structure each member objectively determined by means PSO algorithm, so generalization...
In terms of the Particle Swarm Optimization-Neural Network (PSO-NN), a new prediction model has been developed using stepwise regression method combined with feature extraction technique Isometric Mapping (ISOMAP) algorithm to treat Climatology and Persistence (CLIPER) predictors. The is validated forecasts ten years typhoon intensity formed numbered in Western Pacific Ocean over May-October, 2001-2010. Using identical sample cases, predictions PSO-NN based on ISOMAP are compared CLIPER...
Randomly dividing 160 cases into two groups, the research group was given conventional chemotherapy while other exposed to in vitro cultured calculus bovis, order evaluate impact of this on quality life and immune function those with non-small cell lung cancer undergoing chemotherapy. The clinical efficacy, scale (QLQ-C30, QLQ-LCL3) scores indexes (CD4+, CD8+, CD4+/CD8+) were evaluated after cycles. comparison efficacy between groups yielded significant results (P >0.05). After treatment,...
Previous studies on the association between vitamin E and blood pressure (BP) levels are controversial. Our study aimed to evaluate (alpha-tocopherol gamma-tocopherol) systolic diastolic BP in an adult population with diabetes without diabetes. data were obtained from a biomarker project of Midlife United States (MIDUS) study. A total 1068 subjects included, associations alpha-tocopherol gamma-tocopherol further analyzed by smooth curve multivariate linear regression analyses. analysis...
<title>Abstract</title> Background Pulmonary vein isolation (PVI) is the crucial treatment approach of paroxysmal atrial fibrillation (PAF). The success PVI primarily depends on several factors, including ablation catheter contact force, lesion depth, stability, and point continuity. This project attempted to systematically examine these elements during evaluate how variations in parameters affect safety efficacy patients with PAF. Methods study conducted a retrospective analysis four key...
Abstract In order to effectively improve the detection ability of camouflaged targets and fully utilize potential target algorithms, this paper proposes a method based on fusion thermal infrared saliency map visible image. Firstly, target’s band is obtained through instance segmentation network dedicated target, then fused with image pixel-level weighting, thus obtaining same in two bands, aimed at enhancement specific regions target. The by YOLOv8, experimental results show that has...