A5100395939- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Methane Hydrates and Related Phenomena
- Error Correcting Code Techniques
- Dielectric materials and actuators
- Advanced Wireless Communication Techniques
- Cancer-related molecular mechanisms research
- Structural Health Monitoring Techniques
- Drug-Induced Hepatotoxicity and Protection
- Ferroelectric and Piezoelectric Materials
- Civil and Geotechnical Engineering Research
- Advanced Sensor and Energy Harvesting Materials
- RNA modifications and cancer
- Geophysical and Geoelectrical Methods
- Concrete Corrosion and Durability
- Bone and Dental Protein Studies
- Sirtuins and Resveratrol in Medicine
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Galectins and Cancer Biology
- Whipple's Disease and Interleukins
- Bacillus and Francisella bacterial research
- Advanced Glycation End Products research
- Actinomycetales infections and treatment
- Cancer-related gene regulation
Tongji University
2015-2024
Shanghai Pulmonary Hospital
2009-2024
Institute of Microbiology
2022
Ningbo University
2020-2021
Shanghai Clinical Research Center
2021
Shanghai Tenth People's Hospital
2015
To reach the full potential of polymer dielectrics in advanced electronics and electrified transportation, it calls for efficient operation high-energy-density dielectric polymers under high voltages over a wide temperature range. Here, composites consisting boron nitride nanosheet/polyetherimide TiO2 nanorod arrays/polyetherimide layers are reported. The layered composite exhibits much higher constant than current high-temperature composites, while simultaneously retaining low loss at...
Multiscale internal/external interfaces are constructed to break the paradox of a high dielectric constant with decreased breakdown strength for superior energy storage capability. An ultrahigh discharged density ∼25.26 J cm<sup>−3</sup> is achieved.
Mycobacterial arabinogalactan (AG) is an essential cell wall component of mycobacteria and a frequent structural bio-synthetical target for anti-tuberculosis (TB) drug development. Here, we report that mycobacterial AG recognized by galectin-9 exacerbates infection. Administration AG-specific aptamers inhibits cellular infiltration caused Mycobacterium tuberculosis (Mtb) or bovis BCG, moderately increases survival Mtb-infected mice marinum-infected zebrafish. interacts with carbohydrate...
Purpose Antituberculosis drug-induced liver injury (ATDILI) is one of the most deleterious side effects associated with chemotherapy against tuberculosis (TB). In this study, our objective was to determine incidence, risk factors, and management ATDILI analyze its impact on treatment outcome in patients receiving standard anti-TB chemotherapy. Methods A prospective cohort study prevalence conducted 938 enrolled 1426 TB cases Shanghai from March 2011 September 2012. Patients were followed up...
The neutral axis position is considered as a potential parameter of early abnormal and long term performance for flexural members structures. This paper to propose the Neutral Axis Indicator (NA) based on strain measurements, evaluate behavior NA, investigate challenges associated with structural health monitoring purpose. A numerical example simply supported reinforced concrete (RC) beam was first developed analyzed followed by an experimental study further verification. With aim...
Interleukin-37 (IL-37), a novel member of the IL-1 family, plays fundamental immunosuppressive roles by broadly reducing both innate inflammation and acquired immunity, but whether it is involved in pathogenesis tuberculosis (TB) has not been clearly elucidated. In this study, single nucleotide polymorphism (SNP) analysis demonstrated an association genetic variant rs3811047 IL-37 with TB susceptibility. line previous report, significant elevated abundance sera increased expression protein...
ObjectiveTo evaluate he diagnostic performance of the Xpert Mycobacterium tuberculosis/Rifampin (MTB/RIF) assay in bronchoalveolar lavage fluid (BALF).MethodsWe retrospectively reviewed clinical data from 671 sputum-smear negative or sputum-scarce adult patients with suspected pulmonary tuberculosis (PTB) who had an MTB/RIF performed on BALF. The assay, smear microscopy (SM) and MTB culture was evaluated using final diagnosis as reference standard.ResultsCompared culture, sensitivity...
Mycobacterium tuberculosis (MTB) infection induces cytotoxicity tohost human macrophages.The underlying signaling mechanisms are largely unknown.Here we discovered that MTB induced programmed necrosis in macrophages, causing mitochondrial cyclophilin-D (CypD)-p53-adenine nucleotide translocator type 1 association, depolarization and lactate dehydrogenase medium release.In macrophages infection-induced apoptosis were attenuated by CypD inhibition (by cyclosporin A), silencing knockout, but...
The carbapenem-resistance genes blaVIM are widely disseminated in Pseudomonas, and frequently harbored within class 1 integrons that reside various mobile genetic elements (MGEs). However, there few reports on detailed dissection of blaVIM-carrying MGEs Pseudomonas.This study presented the complete sequences five blaVIM-2/-4-carrying MGEs, including two plasmids, chromosomal integrative mobilizable (IMEs), one conjugative element (ICE) from different Pseudomonas isolates.The plasmids were...
Based on modified LU decomposition theory with pivoting of sparse matrix, a low-complexity real-time LDPC encoder for CMMB was presented, which can support 2 different code rate (1/2 and 3/4). Multi- staged pipeline Pingpong buffer architectures were used to improve throughput. An efficient memory organization storing matrices also presented. Whole design synthesized routed Altera Stratix II EP2S90. Highest frequency achieved over 200 MHz, pure encoding 32.44 Mbps rate) 67.16 (3/4 rate)....
How to design a distributed and open-ended Cyber-Physical system (CPS) architecture is an important issue for constructing different CPS business applications. In this paper, service-oriented proposed, in which software hardware components are represented the form of interoperable services. services combined realize complicated requirements. Further, formal method verifying validity service composition model put forward based on Time-Space ¦Ð-calculus, presented through introducing time...
A Gram-stain-negative bacterial strain, designated as E165T, was isolated from a tidal flat sediment of the East China Sea. Strain E165T grew optimally at pH 6, 32 °C and with 1-2 % (w/v) NaCl. The 16S rRNA gene sequence similarity results revealed that strain most closely related to Marinomonas rhizomae IVIA-Po-145T, polaris CK13T, foliarum IVIA-Po-155T, hwangdonensis HDW-15T, pontica 46-16T, mangrovi B20-1T shanghaiensis DSL-35T values 97.0-98.5 %. digital DNA-DNA hybridization average...
The pathogenic mechanism of antituberculous drug-induced liver injury (ATDILI) is associated with antioxidant enzymes. objective the present study was to investigate associations ATDILI susceptibility genetic polymorphisms enzyme genes including nitric oxide synthase 2 (NOS2), thioredoxin reductase 1 (TXNRD1), superoxide dismutase (SOD2), BTB domain and CNC homolog (BACH1), MAF bZIP transcription factor K (MAFK).Thirty tag single nucleotide (tag-SNPs) from all candidate were genotyped in a...
Tuberculosis is a serious global health burden, resulting in millions of deaths each year. Several circulating cell subsets the peripheral blood are known to modulate host immune response Mycobacterium tuberculosis (Mtb) infection different ways. However, characteristics and functions these varying stages have not been well elucidated. Peripheral cells (PBICs) were isolated from healthy donors (HD group), individuals with mild (MI severe (SE group). CD4+ naive T CD8+ decreased SE MI groups,...
Based on the volume average integration simulation (VISIM) method, a novel geostatistical inversion technique constrained by well‐log, cross‐hole and surface seismic data is presented. The conventional method only uses well‐log as prior information. It means we do not fully utilize information from other survey such rays. In this abstract, present which more relevant including rays are all honored thus better result can be achieved. As result, accuracy of (modeling) greatly improved...