A5018638298- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- AI in cancer detection
- Antifungal resistance and susceptibility
- Cancer Cells and Metastasis
- Fungal Infections and Studies
- Postharvest Quality and Shelf Life Management
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Drug-Induced Hepatotoxicity and Protection
- Colorectal and Anal Carcinomas
- Cancer therapeutics and mechanisms
- Polysaccharides and Plant Cell Walls
- Bacterial Infections and Vaccines
- Amoebic Infections and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
Shandong Provincial Hospital
2024-2025
Karolinska Institutet
2020-2025
Karolinska University Hospital
2020-2025
Shandong University
2025
Yuhuangding Hospital
2025
Air Force Medical University
2025
Xijing Hospital
2025
Shanghai Pulmonary Hospital
2015-2024
The First People’s Hospital of Lianyungang
2022-2024
Tongji University
2015-2024
Metagenomic Next-Generation Sequencing (mNGS) has been applied as a novel method of detection pathogens for infectious diseases, but its value in the rapid diagnosis tuberculous meningitis(TBM)has not clarified based on large samples.A retrospective analysis was conducted 51 inpatients with suspected TBM who underwent mNGS and four other tests cerebrospinal fluid (CSF).Among included patients, 45 cases were diagnosed (38 definite, 5 probable, 2 possible) 6 non-TBM. Using final reference...
With a high incidence rate and mortality rate, tuberculosis (TB) is major public health concern worldwide. There an urgent need to develop the rapid, reliable affordable diagnostic test for detection of Mycobacterium (Mtb). Metagenomic next-generation sequencing (mNGS) showed promising values in rapid diagnosis clinical TB, while studies on application mNGS pulmonary extrapulmonary TB remain scarce.In this study, we collected results both culture 70 specimens from suspected patients at...
The primary aim of this research was to investigate the association between uridine diphosphate glucuronosyltransferase (UGT)1A1 gene polymorphisms and toxicities irinotecan-based regimens in Chinese patients with metastatic colorectal cancer.The study analyzed distribution UGT1A1*28/*6 by polymerase chain reaction amplification pyrosequencing. adverse reactions tumor response were evaluated according National Cancer Institute Common Toxicity Criteria for Adverse Events, Version 3.0,...
Bacterial and fungal infections that caused by various kinds of pathogens are frequently-occurring disease all over the world. To overcome shortcomings traditional culture method, we have adapted next-generation sequencing (NGS) technology to identify pathogens.In this study, clinical samples from 20 patients pre-diagnosed with bacterial in Shanghai Pulmonary Hospital Tongji University, China, were investigated retrospectively compare NGS conventional "gold standard" methods.The detection...
Purpose Antituberculosis drug-induced liver injury (ATDILI) is one of the most deleterious side effects associated with chemotherapy against tuberculosis (TB). In this study, our objective was to determine incidence, risk factors, and management ATDILI analyze its impact on treatment outcome in patients receiving standard anti-TB chemotherapy. Methods A prospective cohort study prevalence conducted 938 enrolled 1426 TB cases Shanghai from March 2011 September 2012. Patients were followed up...
Candida albicans (C. albicans) is one of the important opportunistic fungal pathogens that closely associated with disseminated or chronic infections. The objective this study to evaluate synergistic antifungal effect licofelone, which dual microsomal prostaglandin E2 synthase/lipoxygenase (mPGES-1/LOX) inhibitor in combination fluconazole against C. albicans. Here our results showed licofelone (16μg/mL) can synergistically work (1μg/mL) planktonic cells fluconazole-resistant two-drug...
Ki67 is an important biomarker with prognostic and potential predictive value in breast cancer. However, the lack of standardization hinders its clinical applicability. In this study, we aimed to investigate reproducibility among pathologists following guidelines International Breast Cancer Working Group (IKWG) for scoring evaluate platform independent cohort. Four algorithms were independently built by four based on our study cohort using open-source digital image analysis (DIA) (QuPath)...
Refractory rifampicin-resistant/multidrug resistant/extensively-drug resistant tuberculosis (RR/MDR/XDR-TB) were defined as patients infected with Mycobacterium (MTB) to rifampicin(RR-TB), or at least rifampicin and isoniazid (MDR-TB) added fluoroquinolones (FQs) one of second line injectable agents (XDR-TB), a patient for whom an effective regimen (fewer than 4 due adverse events (AEs) multiple drug resistances) cannot be developed. To compare the effectiveness safety bedaquiline...
To evaluate the Stratipath Breast tool for image-based risk profiling and compare it with an established prognostic multigene assay in a real-world case series of estrogen receptor (ER)-positive human epidermal growth factor 2 (HER2)-negative early breast cancer patients categorized as intermediate based on classic clinicopathological variables eligible chemotherapy.
Immune checkpoint blockade (ICB) has shown promising potential for treating triple-negative breast cancer (TNBC), but its efficacy is limited, mainly due to the "cold," suppressive immune tumor microenvironment (TME). Therefore, improving TME crucial enhancing therapeutic effects against TNBC. Here, we presented a multifunctional nanotherapeutic platform (ALEvs@LNPs) designed combine cytokine-sensitized mild photothermal therapy, ICB, and interleukin-2 (IL2) mRNA therapy reprogram TME,...
Objective This study aimed to provide insight about clinical management of ciliated hepatic foregut cysts (CHFC) at a tertiary centre.
Cleaning the external urethral orifice in patients with indwelling catheters can effectively reduce number of local microorganisms. Employing appropriate disinfection strategies prevent between 17% and 69% catheter-associated urinary tract infection (CAUTI) cases. However, optimal antiseptics their conditions use (temperature, concentration, exposure time) remain unclear. The suspension quantitative bactericidal test method was employed to evaluate efficacy two skin mucous membrane...
The aim of this study was to assess the clinical utility metagenomic next-generation sequencing (mNGS) on smear-negative extrapulmonary specimens collected in China.Specimens were tested by mNGS and other routine tests for tuberculosis (TB). diagnostic accuracy calculated compared with final diagnosis.The sensitivity found be significantly higher than sensitivities TB tests. Receiver operating characteristic curve analysis showed that achieved highest area under (AUC) value 0.79. positive...
The pathogenic fungus Candida albicans is one of the most commonly clinically isolated fungal species, and its resistance to antifungal drug fluconazole known be increasing. In this paper, we sought characterize effect sodium phenylbutyrate used alone or in combination with azoles against resistant C. albicans. minimum inhibitory concentrations sessile were determined explore synergistic mechanism. results showed that exerted clear activity functioned synergistically combat our study...