A5004135193- Systemic Lupus Erythematosus Research
- CAR-T cell therapy research
- Renal Diseases and Glomerulopathies
- Platelet Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Genomics, phytochemicals, and oxidative stress
- Climate Change and Health Impacts
- Cancer-related molecular mechanisms research
- Gout, Hyperuricemia, Uric Acid
- Genetic and Kidney Cyst Diseases
- Fungal Biology and Applications
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Osteoarthritis Treatment and Mechanisms
- Silicon Carbide Semiconductor Technologies
- Diet, Metabolism, and Disease
- Thermoregulation and physiological responses
- Atherosclerosis and Cardiovascular Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Wnt/β-catenin signaling in development and cancer
- Therapeutic Uses of Natural Elements
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adolescent and Pediatric Healthcare
Hospital for Sick Children
2019-2025
Hebei General Hospital
2025
Dongguan People’s Hospital
2023
Peking University Cancer Hospital
2023
SickKids Foundation
2019-2023
The University of Texas MD Anderson Cancer Center
2018-2023
Shaanxi University of Chinese Medicine
2021-2023
Zhongshan Hospital
2021-2023
Fudan University
2021-2023
Sun Yat-sen University
2021-2023
LN is one of the most common and severe manifestations SLE. Our aim was to test association SLE risk loci with in childhood-onset (cSLE) adult-onset (aSLE).Two Toronto-based tertiary care cohorts included cSLE (diagnosed <18 years) aSLE patients ⩾18 years). Patients met ACR and/or SLICC criteria were genotyped on Illumina Multi-Ethnic Global Array or Omni1-Quad arrays. We identified those without biopsy-confirmed LN. HLA non-HLA additive risk-weighted genetic scores (GRSs) tested for...
Genetics significantly impact systemic lupus erythematosus (SLE) risk, disease manifestations, and damage. Our aim was to identify genetic risk loci for activity burden over time. We included participants from a tertiary care Lupus Clinic. Participants met ACR and/or SLICC classification criteria SLE, were genotyped on one of three arrays, had > =3 measures (SLE Disease Activity Index 2000 [SLEDAI-2K]) derive adjusted mean SLEDAI-2K glucocorticoid scores (AMSG). completed genome-wide...
Arterial stiffness plays a key role in the pathogenesis of cardiovascular disease. However, relationship between lipid levels and arterial is controversial. We aimed to investigate association parameters brachial–ankle pulse-wave velocity (baPWV) Chinese patients with hypertension. A total 14 071 participants hypertension China Stroke Primary Prevention Trial (CSPPT) were enrolled present study. Patients assigned 4 equal groups according their baPWV. Participants highest baPWV group older...
Objectives: Warfarin is often used for ischemic stroke prevention in patients with atrial fibrillation (AF), but the factors affecting patient adherence to warfarin therapy have not been fully understood. Methods: A cross-sectional survey was conducted AF undergoing at least 6 months prior study. The clinical data collected using questionnaires by phone interviews included following: 1) self-reported measured Morisky Medication Adherence Scale-8 © ; 2) beliefs about medicines surveyed...
ABSTRACT Objectives: This study investigated the role and potential involvement of pulmonary vascular glycocalyx degradation in acute lung injury rats with severe heatstroke (HS). Methods: Rats an established HS model were exposed to a heated environment for 60 min incubator (temperature, 40°C ± 2°C; humidity, 65% 5%). Following pretreatment heparanase III (HPSE III) or heparin, pathological injury, arterial blood gas, alveolar barrier disruption, hemodynamic changes evaluated. The...
Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent and durable effects in B-cell malignancies. However, loss or downregulation is a frequent cause of resistance. Here, we report development novel CAR T-cell therapy product to target CD79b, pan antigen, widely expressed most lymphomas.
Objectives We aimed to evaluate the relation of total homocysteine (tHcy) concentrations with systolic blood pressure (SBP) and diastolic (DBP) levels, examine possible modifiers in association among a general population Chinese adults. Design A cross-sectional study. Setting The study was conducted within 21 communities Lianyungang Jiangsu province, China. Participants 26 648 participants aged ≥35 years no antihypertensive drug use were included final analysis. Results Overall, there...
The purpose of this study was to investigate the radioprotective effects tea polyphenols (TPs) in various combinations against radiation‐induced damage mice. Mice were divided into different groups: non‐irradiated control, irradiated amifostine (43.6 mg/kg, i.v. 30 min before irradiation; positive control) and doses. effect on haematopoietic system, serum cytokines endogenous antioxidant enzymes studied. TP50, containing approximately 50% (‐)‐epigallochatechin‐3‐gallate addition other...
<h3>Introduction</h3> Steroid-sensitive nephrotic syndrome (SSNS) is the most common form of kidney disease in children worldwide. Genome-wide association studies (GWAS) have demonstrated SSNS with genetic variation at <i>HLA-DQ/DR</i> and identified several non-<i>HLA</i> loci that aid further understanding pathophysiology. We sought to identify additional associated Sri Lankan European ancestry. <h3>Methods</h3> conducted a GWAS cohort individuals comprising 420 pediatric patients 2339...
Background: Primary immune thrombocytopenia (ITP) is an autoimmune-mediated disorder characterized by a decreased platelet count. Systemic lupus erythematosus (SLE) also autoimmune disease in which common hematologic manifestation. Interleukin (IL)-1 family cytokines are major proinflammatory and immunoregulatory mediators. This study aimed to investigate the role of IL-1 patients with ITP SLE potential pathophysiologic mechanism differentiate SLE-associated (SLE-TP) from ITP. Methods:...
Objective Genetics play an important role in systemic lupus erythematosus (SLE) pathogenesis. We calculated the prevalence of rare variants known monogenic genes among children suspected lupus. Methods completed paired-end genome-wide sequencing (whole genome [WGS] or whole exome sequencing) patients lupus, and focused on 36 genes. prioritized (minor allele frequency < 1%) exonic, nonsynonymous, splice with predicted pathogenicity classified as deleterious (Combined Annotation Dependent...
Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common through disruption of their encoded protein. We searched for rare associated with onset ESKD individuals type 1 diabetes at advanced kidney disease stage.
Abstract Background Primary immune thrombocytopenia (ITP) is an autoimmune disease. Some ITP patients are associated with pathogen infection undetected conventional technologies. Investigating the changes of T cells and potential metabolic mechanism important for better understanding ITP. Methods The study enrolled 75 newly diagnosed patients. pathogens were detected by metagenomic next-generation sequencing (mNGS). Plasma lipids measured liquid chromatography-mass spectrometry (LC–MS). CD4...
The viscosity of Chinese rice wine gradually increases with the maturing process, resulting in a better taste due to longer contact tongue. Herein, structure water–ethanol was detected by hydrogen nuclear magnetic resonance (1H-NMR) and measurement define strength bonding. Through single-factor experiments, it can be seen that most flavors have promoting effect on alcohol–water bonding, exception aldehydes. And factors influencing bonding decreasing order were determined Plackett–Burman (PB)...