A5100627590- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Mycotoxins in Agriculture and Food
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Carcinogens and Genotoxicity Assessment
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- TGF-β signaling in diseases
- Circular RNAs in diseases
- Redox biology and oxidative stress
- Cancer Cells and Metastasis
- Advanced Glycation End Products research
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Liver physiology and pathology
- Plant Disease Resistance and Genetics
Second Xiangya Hospital of Central South University
2014-2024
Central South University
2014-2024
Children's Hospital of Zhejiang University
2024
Hebei Medical University
2015-2024
Southwest University
2024
Second Hospital of Hebei Medical University
2014-2024
Shanghai Institute of Organic Chemistry
2024
University of Chinese Academy of Sciences
2024
Shandong University
2011-2023
Guangzhou University of Chinese Medicine
2023
Ischemic tissues require mechanisms to alert the immune system of impending cell damage. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from ischemic cells. We elucidate mechanism by which HMGB1, one key alarm molecules during liver ischemia/reperfusion (I/R), is mobilized in response hypoxia. HMGB1 release cultured hepatocytes was found be an active process regulated reactive oxygen species (ROS). Optimal production ROS and subsequent...
Abstract Bone tissue has a strong ability to repair itself. When treated properly, most fractures will heal well. However, some are difficult heal. fracture does not heal, it is called nonunion. Approximately, 5% of all patients have difficulty healing. Because the continuous movement site, bone nonunion usually accompanied by pain, which greatly reduces quality life patients. marrow mesenchymal stem cells (BMSCs) play an important role in process Circular RNAs (circRNAs) unique kind...
Abstract The chromatin-binding factor high-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and late mediator of mortality in murine endotoxemia. Although serine phosphorylation HMGB1 is necessary for nucleocytoplasmic shuttling before its cellular release, the protein kinases involved have not been identified. To investigate if calcium/calmodulin-dependent kinase (CaMK) IV phosphorylates mediates release from macrophages (Mφ) stimulated with LPS, RAW 264.7 cells or...
Abstract Long noncoding RNAs (lncRNAs) are emerging as key regulators in cancer initiation and progression. TP53TG1 is a recently identified lncRNA several studies have shown that may play the role of tumor suppressor gene or oncogene different tumors. Nevertheless, involvement carcinogenesis pancreatic ductal adenocarcinoma (PDAC) has not been characterized. In our studies, we was highly expressed PDAC novel regulator development. Knockdown inhibited proliferation, induced apoptosis,...
Controllable fluorocarbon chain elongation (CFCE) is a promising yet underdeveloped strategy for the well-defined synthesis of structurally novel polyfluorinated compounds. Herein, direct and efficient trifluorovinylation pentafluorocyclopropylation aldehydes are described by using TMSCF
Pim-1 kinase is a proto-oncogene and its dysregulation contributes to tumorigenesis progression of variety malignancies. was suggested as therapeutic target cancers. The functional relevance the mechanism underlying in lung remained unclear. This study aimed investigate if has important functions non-small-cell cancer (NSCLC) by: 1) evaluating clinicopathologic significance through analysing expression 101 human NSCLCs tissues using quantitative PCR, Western Blot immunohistochemical studies,...
Abstract Nitric oxide signaling plays complex roles in carcinogenesis, part, due to incomplete mechanistic understanding. In this study, we investigated our discovery of an inverse correlation the expression inducible nitric synthase (iNOS) and Wnt/β-catenin regulator Dickkopf-1 (DKK1) human cancer. tumors animal models, induced synthesis increased by negatively regulating DKK1 gene expression. Human iNOS (hiNOS) were inversely correlated primary colon breast cancers, intestinal adenomas...
Long non‑coding RNAs (lncRNAs) have emerged as key players in the development and progression of cancer. FEZ family zinc finger 1 antisense RNA (FEZF1‑AS1) is a novel lncRNA that involved cancer acts potential biomarker for However, clinical significance molecular mechanism FEZF1‑AS1 non‑small cell lung (NSCLC) remains uncertain. In present study, was selected using Arraystar Human microarray identified to be upregulated NSCLC tissues negatively associated with overall survival patients...
Abstract Bone is one of the most frequent sites for metastasis in breast cancer patients. significantly reduces survival time and life quality Germacrone (GM) can serve humans as an anti‐cancer anti‐inflammation agent, but its effect on cancer‐induced osteolysis remains unclear. This study aims to investigate functions mechanisms GM alleviating osteolysis. The effects osteoclast differentiation, bone resorption, F‐actin ring formation, gene expression were examined vitro. RNA‐sequencing...
ABSTRACT. TGF-β1 is a profibrotic cytokine that plays central role in the onset and progression of chronic renal diseases. The activity tightly controlled by multiple mechanisms, which antagonizing Smad-mediated gene transcription co-repressors an important regulatory component. This study examined expression Smad transcriptional fibrotic kidney investigated their potential functions controlling response. Western blot analysis demonstrated protein levels SnoN Ski were progressively reduced...
Osteosarcoma (OS) is a frequently observed primary malignant tumor. Current therapy for osteosarcoma consists of comprehensive treatment. The long-term survival rate patients exhibiting nonmetastatic OS varies between 65‑70%. However, number cases have been to be resistant currently used therapies, leading disease recurrence and lung metastases, which are the reasons patient mortality. In present review, pieces evidence provide support potential uses immunotherapy, including immunomodulation...
Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and stimulation these cells is thought to an important development silicosis. The present study was undertaken investigate anti-fibrotic effects dibutyryl-cAMP (db-cAMP) on rats induced by silica. A HOPE MED 8050 exposure control apparatus used create silicosis model. Rats were randomly divided into 4 groups: 1)controls for 16 w; 2)silicosis 3)db-cAMP pre-treatment; 4) db-cAMP post-treatment. Rat pulmonary...
Tumor-associated inflammation plays a critical role in facilitating tumor growth, invasion and metastasis. Our previous study showed Aflatoxin G1 (AFG1) could induce lung adenocarcinoma mice. Chronic associated with superoxide dismutase (SOD)-2 upregulation was found the carcinogenesis. However, it is unclear whether tumor-associated mediates SOD-2 to contribute cell AFG1-induced adenocarcinoma. Here, we increased expression vimentin, α-SMA, Twist1, MMP inflammatory microenvironment also...
Abstract Pain, physical dysfunction, and mental disorders caused by bone nonunion bring great burden to patients. Bone mesenchymal stem cells (BMSCs) isolated from patients with poor proliferation osteogenic ability are compared that normal bone-healing Long noncoding RNAs (lncRNAs) a class of more than 200 nucleotides in length, lack an open-reading frame encoding protein, have little or no protein-coding function, could regulate gene expression, which is involved the regulation important...
Glioblastoma (GBM) is the most common and malignant brain tumor in adults. Recently, programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) checkpoint blockades have been applied for GBM treatment. However, mechanism of PD-L1 upregulation still unclear. COP9 signalosome 6 (CSN6) crucial maintaining protein stabilization cancer cells. In this study, we human specimens cell lines to investigate whether EGFR-ERK pathway regulates CSN6 upregulation. Data from The Cancer Genome Atlas dataset...