A5004798984- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Dysphagia Assessment and Management
- Head and Neck Cancer Studies
- Gastroesophageal reflux and treatments
- Voice and Speech Disorders
- Sleep and Wakefulness Research
- Respiratory and Cough-Related Research
- interferon and immune responses
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- RNA modifications and cancer
- Airway Management and Intubation Techniques
- Cancer-related gene regulation
- Inhalation and Respiratory Drug Delivery
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Reconstructive Facial Surgery Techniques
- Clusterin in disease pathology
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Xi'an Jiaotong University
2012-2024
Guangdong Provincial Center for Disease Control and Prevention
2013
Tang Du Hospital
2005
To develop a deep learning (DL) model for obstructive sleep apnea (OSA) detection and severity assessment provide new approach convenient, economical, accurate disease detection. Considering medical reliability acquisition simplicity, we used electrocardiogram (ECG) oxygen saturation (SpO In the hospital dataset, accuracy (Acc) values of per-segment per-recording were 91.38 96.08%, respectively. The Acc mild, moderate, severe OSA 90.20, 88.24, 92.16%, Bland‒Altman plots revealed consistency...
Obstructive sleep apnea (OSA) is a globally prevalent disease with complex diagnostic method. Severe OSA associated multi-system dysfunction. We aimed to develop an interpretable machine learning (ML) model for predicting the risk of severe and analyzing factors based on clinical characteristics questionnaires.This was retrospective study comprising 1656 subjects who presented underwent polysomnography (PSG) between 2018 2021. A total 23 variables were included, after univariate analysis, 15...
Background & AimsNOTCH signaling in liver sinusoidal endothelial cells (LSECs) regulates fibrosis, a pathological feature of chronic diseases. POFUT1 is an essential regulator NOTCH signaling. Here, we investigated the role LSECs-expressed fibrosis.MethodsEndothelial-specific Pofut1 knockout mice were generated and subjected to experimental fibrosis by carbon tetrachloride exposure or common bile duct ligation. Liver samples assessed ELISA, histology, electron microscopy, immunostaining RNA...
Abstract The critical role of the tumor immune microenvironment (TIME) in determining response to checkpoint inhibitor (ICI) therapy underscores importance understanding cancer cell–intrinsic mechanisms driving immune-excluded (“cold”) TIMEs. One such cold is oral cavity squamous cell carcinoma (OSCC), a tobacco-associated with mutations TP53 gene which responds poorly ICI therapy. Because altered function promotes progression and plays potential TIME modulation, here we developed syngeneic...
Seasonal allergic rhinitis (SAR) places a significant socioeconomic burden, particularly on individuals with poorly managed recurrent and severe symptoms despite standard-of-care treatment. Stapokibart, humanized monoclonal antibody that targets the interleukin (IL)-4 receptor subunit alpha, inhibits its interaction both IL-4 IL-13 in type 2 inflammation. Here we aim to assess efficacy safety of stapokibart as an add-on therapy adults moderate-to-severe SAR. The study was phase 3...
Background TP53 , the most mutated gene in solid cancers, has a profound impact on hallmarks of cancer. Somatic mutations occur high frequencies head and neck including oral squamous cell carcinoma (OSCC). Our study aims to understand role gain-of-function mutation modulating tumor immune microenvironment (TIME) OSCC. Methods Short hairpin RNA knockdown mutant p53R172H syngeneic tumors demonstrated changes growth between immunocompetent immunodeficient mice. HTG EdgeSeq targeted messenger...
Sprouting of mossy fibers, one the most consistent findings in tissue from patients with mesial temporal lobe epilepsy, exhibits several uncommon axonal growth features and has been considered a paradigmatic example circuit plasticity that occurs adult brain. Clarifying mechanisms responsible may provide new insight into epileptogenesis as well axon misguidance central nervous system. Methyl-CpG-binding protein 2 (MeCP2) binds to methylated genomic DNA regulate range physiological functions...
Abstract Objective To assess the extent of recurrent laryngeal nerve (RLN) and superior (SLN) damage in patients with idiopathic vocal cord paralysis (IVCP) exhibiting different paralytic sides. Methods A total 84 IVCP cases were evaluated using stroboscopic laryngoscopy, voice analysis, electromyography (LEMG). The results compared between left‐sided right‐sided based on disease courses (less than or more 3 months). Results Initially, average age progression found to be similar regardless...
Abstract Although the principle of systemic treatment to prevent progression oral premalignant lesions (OPL) has been demonstrated, there remains a lack consensus about an optimal approach that balances clinical efficacy with toxicity concerns. Recent advances in cancer therapy using approaches targeting tumor immune microenvironment (TIME) including immune-checkpoint inhibitors indicate these agents have significant clinically activity against different types cancers, cancer, and therefore...
Abstract Background Obstructive sleep apnea (OSA) is mainly characterized by fragmentation and chronic intermittent hypoxia (CIH), the latter one being associated with multiple organ injury. Recently, OSA-induced cognition dysfunction has received extensive attention from scholars. Astrocytes are essential in neurocognitive deficits via A1/A2 phenotypic changes. Nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome considered most important factor inducing...
Obstructive sleep apnea (OSA) is a globally prevalent disease closely associated with hypertension. To date, no predictive model for OSA-related hypertension has been established. We aimed to use machine learning (ML) construct analyze risk factors and predict hypertension.We retrospectively collected the clinical data of OSA patients diagnosed by polysomnography from October 2019 December 2021 randomly divided them into training validation sets. A total 1,493 27 variables were included....
Abstract Human cholesteatoma perimatrix fibroblasts (hCPFs) can stimulate the endothelial cells of nearby microvessels to proliferate and migrate in a paracrine manner. Exosomes, secreted from various cell types, are one most important factors play critical roles intercellular communication. However, whether exosomes derived human (hCPFs‐Exo) promote angiogenesis has not been reported. In this study, we isolated by hCPFs observed that hCPFs‐Exo was able migration tube formation umbilical...
Aberrant methylation is one of the most frequent epigenetic alterations that regulate expression levels genes, including long non‑coding RNAs (lncRNAs), in tumors. However, to best our knowledge, and function hepatic nuclear factor 1α antisense RNA 1 (HNF1A‑AS1) its condition have not yet been reported development progression laryngeal squamous cell carcinoma (LSCC). In present study, HNF1A‑AS1 were first examined by reverse transcription‑quantitative PCR, bisulfite genomic sequencing...
Background As an important neuroprotective factor, the brain-derived neurotrophic factor (BDNF) may have a key role in cognitive impairment children with sleep-disordered breathing (SDB). The main aim of this study was to compare levels BDNF and tyrosine kinase receptor B (TrkB) normal those obstructive sleep apnea (OSA) primary snoring (PS) explore possible link between BDNF/TrkB, inflammation, SDB children. Methods A total 44 OSA 35 PS who completed polysomnography October 2017 2019 were...
Objective Previous studies have shown that patients with obstructive sleep apnea syndrome (OSAS) may various vestibular abnormalities, and these mainly present as subclinical lesions. In this study, we attempted to combine ocular vestibular-evoked myogenic potentials (VEMPs) cervical investigate dysfunction in OSAS. Methods Thirty-eight severe OSAS 42 healthy controls were enrolled divided into two groups according results of polysomnography. All parameters VEMP graphs analyzed. Results The...
Swallowing function and swallowing-related quality of life (QoL) can be adversely affected in patients after partial laryngectomy, but are often neglected by clinical workers. This study aimed to investigate the degree swallowing QoL laryngectomy with laryngeal carcinoma.Sixty-eight hospitalized undergoing due carcinoma at Second Affiliated Hospital Xi'an Jiao Tong University were included this prospective study. A general information questionnaire was used collect baseline characteristics....