Xiao‐Lin Wu

ORCID: 0000-0002-5604-9220
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About
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Research Areas
  • Genetic and phenotypic traits in livestock
  • Genetic Mapping and Diversity in Plants and Animals
  • Cancer-related molecular mechanisms research
  • Genetics and Plant Breeding
  • Milk Quality and Mastitis in Dairy Cows
  • Gene expression and cancer classification
  • Thermal Regulation in Medicine
  • Reproductive Physiology in Livestock
  • Adipose Tissue and Metabolism
  • Microbial bioremediation and biosurfactants
  • Neurogenesis and neuroplasticity mechanisms
  • Anesthesia and Neurotoxicity Research
  • Enhanced Oil Recovery Techniques
  • Intensive Care Unit Cognitive Disorders
  • Effects of Environmental Stressors on Livestock
  • Molecular Biology Techniques and Applications
  • Methane Hydrates and Related Phenomena
  • Hydrocarbon exploration and reservoir analysis
  • Neuroscience and Neuropharmacology Research
  • Mitochondrial Function and Pathology
  • Animal Genetics and Reproduction
  • Peroxisome Proliferator-Activated Receptors
  • Animal Behavior and Welfare Studies
  • Genetic diversity and population structure
  • Ruminant Nutrition and Digestive Physiology

Xi'an Jiaotong University
2019-2025

North China University of Water Resources and Electric Power
2025

Daqing Oilfield General Hospital
2012-2024

Dairy Management
2021-2024

University of Wisconsin–Madison
2011-2024

Daqing Oilfield of CNPC
2019-2024

Shandong University of Traditional Chinese Medicine
2024

Qingdao University
2020-2024

Affiliated Hospital of Qingdao University
2020-2024

Beijing Proteome Research Center
2024

The use of structural equation models for the analysis recursive and simultaneous relationships between phenotypes has become more popular recently. aim this paper is to illustrate how these can be applied in animal breeding achieve parameterizations different levels complexity and, specifically, model phenotypic recursion three calving traits: gestation length (GL), difficulty (CD) stillbirth (SB). All considered here postulate heterogeneous GL liabilities CD SB, liability depending on...

10.1186/1297-9686-42-1 article EN cc-by Genetics Selection Evolution 2010-01-25

Abstract Background and Aims Stool DNA testing is an emerging attractive option for colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool (sDNA) test methylated SDC2 CRC detection. The aim this study was to assess its performance in multicenter clinical trial setting. Methods Each participant required undergo sDNA reference colonoscopy. consists quantitative assessment methylation status promoter. Results real-time methylation-specific PCR were dichotomized as...

10.1186/s13148-020-00954-x article EN cc-by Clinical Epigenetics 2020-10-30

Structural equation models (SEMs) are multivariate specifications capable of conveying causal relationships among traits. Although these offer insights into how phenotypic traits relate to each other, it is unclear whether and they can improve multiple-trait selection. Here, we explored concepts involved in SEMs, seeking for benefits that could be brought breeding programs, relative the standard multitrait model (MTM) commonly used. Genetic effects pertaining SEMs MTMs have distinct...

10.1534/genetics.113.151209 article EN Genetics 2013-04-23

To increase the themosensitive behavior and antibacterial activity of cotton fabric, a series poly (N-isopropylacrylamide)/chitosan (PNIPAAm/Cs) hydrogels was synthesized by interpenetrating polymer network (IPN) technology using redox initiator. The IPN PNIPAAm/Cs hydrogel characterized Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA). results indicated that has lower critical solution temperature (LCST) at 33 °C....

10.3390/polym8040110 article EN Polymers 2016-03-28

Current understanding of the diversity, biology, and ecology Archaea is very limited, especially considering how few known phyla have been cultured or genomically explored. The reconstruction “ Ca . Methanomixophus” MAGs not only expands range metabolic versatility members Archaeoglobi but also suggests that phylogenetic distribution MCR MTR complexes even wider than previously anticipated.

10.1128/msystems.00651-19 article EN cc-by mSystems 2020-03-16

Significant advancements have been made by Large Language Models (LLMs) in the domains of natural language understanding and automated content creation. However, they still face persistent problems, including substantial computational costs inadequate availability training data. The combination Federated Learning (FL) LLMs (federated LLMs) offers a solution leveraging distributed data while protecting privacy, which positions it as an ideal choice for sensitive domains. suffer from...

10.48550/arxiv.2502.11863 preprint EN arXiv (Cornell University) 2025-02-17

This study examines the impact of sintering air volume on characteristics combustible lean gases (CO, H2, and CH4) in flue gas. By conducting experiments using a fixed combustion test bench, we analyzed changes negative pressure, gas composition, sinter quality under various conditions. The results demonstrate that an 90 m³/(m²·min) leads to lower ratio (ω(CO)/ω(CO + CO2)), indicating more efficient utilization fuel chemical energy. Additionally, increasing per unit area reduces time. mass...

10.1038/s41598-024-81492-x article EN cc-by-nc-nd Scientific Reports 2025-04-01

Structural equation models (SEMs) of a recursive type with heterogeneous structural coefficients were used to explore biological relationships between gestation length (GL), calving difficulty (CD), and perinatal mortality, also known as stillbirth (SB), in cattle, the last two traits having categorical expression. An acyclic model was assumed, where effects existed from GL phenotype liabilities (latent variables) CD SB liability that considering four periods regarding GL. The data contained...

10.1534/genetics.108.094888 article EN Genetics 2008-11-05

Sheep are among the major economically important livestock species worldwide because animals produce milk, wool, skin, and meat. In present study, Illumina OvineSNP50 BeadChip was used to investigate genetic diversity genome selection Suffolk, Rambouillet, Columbia, Polypay, Targhee sheep breeds from United States. After quality-control filtering of SNPs (single nucleotide polymorphisms), we 48,026 SNPs, including 46,850 on autosomes that were in Hardy-Weinberg equilibrium 1,176 chromosome ×...

10.1371/journal.pone.0065942 article EN cc-by PLoS ONE 2013-06-10

Summary Imputation of moderate-density genotypes from low-density panels is increasing interest in genomic selection, because it can dramatically reduce genotyping costs. Several imputation software packages have been developed, but they vary accuracy, and imputed may be inconsistent among methods. An AdaBoost-like approach proposed to combine results several independent packages, i.e. Beagle(v3.3), IMPUTE(v2.0), fastPHASE(v1.4), AlphaImpute, findhap(v2) Fimpute(v2), with each package...

10.1017/s001667231200033x article EN Genetics Research 2012-06-01

Abstract Between 6 and 30% of human mouse transcripts are initiated from transposable elements. However, the promoters driving such transcriptional activity mostly unknown. We experimentally characterized an antisense (AS) promoter in L1 retrotransposons for first time, oriented antiparallel to coding strand open reading frame-1. found that AS transcription is mediated by RNA polymerase II. Rapid amplification cDNA ends cloning mapped start sites adjacent promoter. identified >100...

10.1093/nar/gku091 article EN cc-by Nucleic Acids Research 2014-01-31

The Illumina BovineSNP50 BeadChip features 54,001 informative single nucleotide polymorphisms (SNPs) that uniformly span the entire bovine genome. Among them, 52,255 SNPs have locations assigned in current genome assembly (Btau_4.0), including 19,294 (37%) intragenic (i.e., located within genes) and 32,961 (63%) intergenic between genes). While represented on Bovine50K are evenly distributed along each chromosome, there over 14,000 genes no placed BeadChip. Kernel density estimation, a...

10.7150/ijbs.7.18 article EN cc-by-nc International Journal of Biological Sciences 2011-01-01

Construction of next-generation sequencing (NGS) libraries involves RNA manipulation, which often creates noisy, biased, and artifactual data that contribute to errors in transcriptome analysis. In this study, a total 19 whole termini site (WTTS-seq) seven (RNA-seq) were prepared from Xenopus tropicalis adult embryo samples determine the most effective library preparation method maximize transcriptomics investigation. We strongly suggest appropriate primers/adaptors are designed inhibit...

10.1534/genetics.116.188508 article EN Genetics 2016-04-21

Sprouting of mossy fibers, one the most consistent findings in tissue from patients with mesial temporal lobe epilepsy, exhibits several uncommon axonal growth features and has been considered a paradigmatic example circuit plasticity that occurs adult brain. Clarifying mechanisms responsible may provide new insight into epileptogenesis as well axon misguidance central nervous system. Methyl-CpG-binding protein 2 (MeCP2) binds to methylated genomic DNA regulate range physiological functions...

10.1016/j.nbd.2023.106346 article EN cc-by-nc-nd Neurobiology of Disease 2023-11-01

Porcine reproductive and respiratory syndrome (PRRS) has devastated pig industries worldwide for many years. It is caused by a small RNA virus (PRRSV), which targets almost exclusively monocytes or macrophages. In the present study, five SAGE (serial analysis of gene expression) libraries derived from 0 hour mock-infected 6, 12, 16 24 hours PRRSV-infected porcine alveolar macrophages (PAMs) produced total 643,255 sequenced tags with 91,807 unique tags. Differentially expressed (DE) were then...

10.1371/journal.pone.0059229 article EN cc-by PLoS ONE 2013-03-19

Low-density (LD) single nucleotide polymorphism (SNP) arrays provide a cost-effective solution for genomic prediction and selection, but algorithms computational tools are needed the optimal design of LD SNP chips. A multiple-objective, local optimization (MOLO) algorithm was developed chips that can be imputed accurately to medium-density (MD) or high-density (HD) genotypes prediction. The objective function facilitates maximization non-gap map length system information chip, latter is...

10.1371/journal.pone.0161719 article EN public-domain PLoS ONE 2016-09-01

SNPs are informative to estimate genomic breed composition (GBC) of individual animals, but selected for this purpose were not made available in the commercial bovine SNP chips prior present study. The primary objective study was select five common panels estimating GBC animals initially involving 10 cattle breeds (two dairy and eight beef breeds). performance evaluated based on admixture model linear regression model, respectively. Finally, downstream implication prediction accuracies...

10.1186/s12863-018-0654-3 article EN cc-by BMC Genomic Data 2018-08-09
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