A5067317868- Fluoride Effects and Removal
- Folate and B Vitamins Research
- Photodynamic Therapy Research Studies
- Bone and Dental Protein Studies
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Air Quality and Health Impacts
- Dermatologic Treatments and Research
- Vascular Malformations and Hemangiomas
- Climate Change and Health Impacts
- Dental Health and Care Utilization
- Nanoplatforms for cancer theranostics
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Selenium in Biological Systems
- Health, Environment, Cognitive Aging
- Advanced Breast Cancer Therapies
- Heme Oxygenase-1 and Carbon Monoxide
- Mitochondrial Function and Pathology
- Bone Metabolism and Diseases
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Oral and Maxillofacial Pathology
Zhengzhou University
2015-2025
Innovation Team (China)
2020-2025
National Health and Family Planning Commission
2023-2025
Shanghai Ninth People's Hospital
2014-2025
State Power Investment Corporation (China)
2025
Shanghai Jiao Tong University
2014-2024
Qilu Hospital of Shandong University
2013-2024
Yellow River Institute of Hydraulic Research
2020-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Universidad Católica de Santa Fe
2024
The noninvasive nature of photodynamic therapy (PDT) enables the preservation organ function in cancer patients.However, PDT is impeded by hypoxia tumor microenvironment (TME) caused high intracellular oxygen (O 2 ) consumption and distorted blood vessels.Therefore, increasing generation TME would be a promising methodology for enhancing PDT.Herein, we proposed concept ferroptosis-promoted based on biochemical characteristics cellular ferroptosis, which improved efficacy significantly...
A supramolecular drug delivery system has been developed via the self-assembly of a amphiphilic polymer, which is constructed by host–guest interaction hydrophilic PEGylated calix[4]arene and hydrophobic photosensitizer chlorin e6. It provides new strategy for preparation polymeric micelles, plays an important role in biological applications.
Rationale: Potential adverse effects of fluoride on neurodevelopment has been extensively explored and mitochondria have recognized as critical targets. Mitochondrial biogenesis serves a crucial role in maintaining mitochondrial homeostasis salubrious properties resveratrol (RSV) well-defined. However, the molecular mechanisms governing developmental neurotoxicity remain unclear related therapeutic dietary agent is lacking. Methods: In vitro neuroblastoma SH-SY5Y cells vivo Sprague-Dawley...
Unlike advances in the genomics-driven precision treatment of cutaneous melanomas, current poor understanding molecular basis mucosal melanomas (MM) has hindered such progress for MM patients. Thus, we sought to characterize genomic landscape identify alterations with prognostic and/or therapeutic implications.Whole-genome sequencing (WGS) was performed on 65 samples, including 63 paired tumor blood samples and 2 matched lymph node metastases, a further droplet digital PCR-based validation...
Thyroid hormones (THs) are critical for brain development. Whether low-moderate fluoride exposure affects thyroid function and what the impact is on children's intelligence remain elusive. We conducted a cross-sectional study to examine associations between in relation intelligence. recruited 571 resident children, aged 7–13 years, randomly from endemic non-endemic fluorosis areas Tianjin, China. measured concentrations drinking water urine using national standardized ion selective electrode...
Chronic cerebral hypoperfusion (CCH) is the leading cause of small vessel disease (CSVD). CCH strongly associated with blood-brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD. However, effects on BBB integrity components cellular molecular mechanisms underlying remain elusive. Whether maintaining can reverse CCH-induced brain damage has also not been explored.In this study, we established a rat model CSVD via permanent bilateral common carotid artery occlusion (2VO) to...
Background and Objectives Photodynamic therapy (PDT) has shown potentially beneficial results in treating port-wine stain, but its benefit–risk profile remains undefined. This study aimed to evaluate the efficacy safety of PDT conducted with hemoporfin a 532 nm continuous wave laser treat stain clinically. Patients Methods randomized clinical trial was eight hospitals China. Participants were adolescent adult patients (age range: 14–65 years old) stain. During stage 1 (day week 8) all at 3:1...
Rationale: Photodynamic therapy (PDT), an O 2 -dependent treatment for inhibition of cancer proliferation, suffers from the low therapeutic effect in clinical application due to hypoxic microenvironment tumor cells.Methods: To overcome this obstacle, a stimuli-responsive drug delivery system with self-sufficiency effective PDT was developed.In study, pH-responsive aerobic nanoparticles were prepared by electrostatic interaction between -evolving protein Catalase and Chitosan.Subsequently,...
Polybrominated diphenyl ethers (PBDEs)-induced neurotoxicity is closely associated with mitochondrial abnormalities. Mitochondrial fusion and fission dynamics are required for the maintenance of homeostasis. However, little known about how PBDEs disrupt this whether such disruption contributes to impaired neurodevelopment. Methods: We investigated effects 2, 2', 4, 4'-tetrabromodiphenyl ether (PBDE-47), dominant congener in human samples, on using PC12 cells, a well-defined vitro...
A combination of nanoparticle delivery Wnt-1 siRNA with photodynamic therapy was realized by inhibiting epithelial–mesenchymal transition.
Apoptosis is involved in 2,2',4,4'- tetrabromodiphenyl ether (PBDE-47)-induced developmental neurotoxicity. However, little known about the role of autophagy, especially its relationship with apoptosis underlying such neurotoxic process. Methods: Using female Sprague-Dawley rats exposed to low-dose PBDE-47 (0.1, 1.0 and 10 mg/kg/day) from pre-pregnancy until weaning offspring mimic human exposure, we investigated effects on autophagy relation cognitive impairment adult rats. We also...
Background and objective Moyamoya disease (MMD) is an increasingly recognised cause of stroke, mainly described in East Asia. China the largest nation Asia, but few studies reported epidemiology MMD, especially at a national level. We aimed to estimate incidence prevalence MMD China. Methods performed population-based study using data from databases Urban Basic Medical Insurance between 2013 2016, covering approximately 0.50 billion individuals. cases were identified by diagnostic code...
Glucose-6-phosphate dehydrogenase (G6PD) is involved in the catalytic pentose phosphate pathway (PPP), which closely related to energy metabolism. G6PD plays a crucial role many types of cancer, but specific molecular mechanisms cancer remain unclear. Therefore, we investigated potential oncogenic various tumors based on The Cancer Genome Atlas (TCGA), cBioPortal datasets, University California Santa Cruz (UCSC) Xena browser, and UALCAN-based online tool. was highly expressed several tissues...
Background/purpose: This phase IIa study aimed to the efficacy and safety of hemoporfin in photodynamic therapy (PDT) with a 532 nm continuous laser for port‐wine stain (PWS). Methods: In this 8‐week open‐labeled three centers, different exposure times (532 20, 30 40 min) were used stage I, group A, II, B III, C, respectively. Primary assessment was performed by an independent experts, who reviewed standardized photos. Secondary consisted subjective grading PWS fading investigators patients....