A5024228842- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Protein Degradation and Inhibitors
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Melanoma and MAPK Pathways
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Nanoparticle-Based Drug Delivery
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Advanced Fluorescence Microscopy Techniques
- Advanced Photocatalysis Techniques
- Neuroendocrine Tumor Research Advances
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
Shanghai Ninth People's Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Stomatology Hospital
2024
National Clinical Research
2023
Shanghai Stomatological Hospital
2023
National Clinical Research Center for Digestive Diseases
2020
WuXi AppTec (China)
2016
Although immunotherapy has revolutionized oncotherapy, only ≈15% of head and neck squamous cell carcinoma (HNSCC) patients benefit from the current therapies. An immunosuppressive tumor microenvironment (TME) dysregulation polycomb ring finger oncogene BMI1 are potential reasons for failure. Herein, to promote immunotherapeutic efficacy against HNSCC, an injectable nanocomposite hydrogel is developed with a polymer framework (PLGA-PEG-PLGA) that loaded both imiquimod encapsulated CaCO3...
Unlike advances in the genomics-driven precision treatment of cutaneous melanomas, current poor understanding molecular basis mucosal melanomas (MM) has hindered such progress for MM patients. Thus, we sought to characterize genomic landscape identify alterations with prognostic and/or therapeutic implications.Whole-genome sequencing (WGS) was performed on 65 samples, including 63 paired tumor blood samples and 2 matched lymph node metastases, a further droplet digital PCR-based validation...
Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute initiation squamous cell carcinoma (OSCC). However, cellular compositions and spatial organization precancerous stage how these factors promote human OSCC remain unclear. Here, we built a single-cell transcriptome atlas map after obtaining data from pairwise mucosal biopsies 9 individuals consisting very early-stage OSCC, adjacent with as well matched normal region. An altered...
Head and neck squamous cell carcinoma (HNSCC) is a common frequently lethal cancer with few therapeutic options. In particular, there are effective targeted therapies. Development of highly strategies tailored to patients HNSCC remains pressing challenge. To address this, we present pharmacogenomic study facilitate precision treatments for HNSCC. We established large collection 56 patient-derived cells (PDCs), which recapitulated the molecular features original tumors. Pharmacological...
The aberrant activation of STAT3 is associated with the etiology and progression in a variety malignant epithelial-derived tumors, including head neck squamous cell carcinoma (HNSCC) colorectal cancer (CRC). Due to lack an enzymatic catalytic site or ligand-binding pocket, there are no small-molecule inhibitors directly targeting that have been approved for clinical translation. Emerging proteolysis chimeric (PROTAC) technology–based approach represents potential strategy overcome...
Abstract Stimuli‐responsive nanomedicines have become a recent research focus as candidate for cancer treatment because of their effectiveness, sensibility, and minimal invasiveness. In this work, novel nanosystem is developed based on Cu 2− x S@MnS core–shell nanoparticles (CSNPs) in which the S core serves photosensitizer to generate hyperthermia reactive oxygen species (ROS), MnS shell used H 2 O ‐responsive production. −x CSNPs with an independent ratio are synthesized by controllable...
Mucosal melanoma (MM), an aggressive rare subtype of melanoma, is distinct from cutaneous and has poor prognoses. We addressed the lack cell models for MM by establishing 30 organoids human oral (OMM), which retained major histopathological functional features parental tumors. Organoid groups derived chronologically or intratumorally lesions within same individual displayed heterogeneous genetics, expression profiles, drug responses, indicating rapid tumor evolution clinical response....
Abstract Cancer cell membrane (CCM) derived nanotechnology functionalizes nanoparticles (NPs) to recognize homologous cells, exhibiting translational potential in accurate tumor therapy. However, these nanoplatforms are majorly generated from fixed lines and typically evaluated line-derived subcutaneous-xenografts (CDX), ignoring the heterogeneity differentiation inter- intra- individuals microenvironments between heterotopic- orthotopic-tumors, limiting therapeutic efficiency of such...
Abstract Cetuximab is a widely used drug for treating head and neck squamous cell carcinomas (HNSCCs); however, it provides restricted clinical benefits, its response duration limited by resistance. Here, we conducted randomized “Phase II-like trials” of 49 HNSCC PDX models reveal multiple informative biomarkers intrinsic resistance to cetuximab (e.g., amplification ANKH , up-regulation PARP3). After validating these in another cohort (61 models), generated acquired analyzed them uncover...
To identify new biomarkers of prostate cancer (PCa) for the diagnosis and prediction clinical outcomes. Existing microarray data PCa tissues in Oncomine database were analyzed candidate differentially expressed genes (DEGs) that may be novel noninvasive obtained. On this basis, plasma mRNA was extracted from patients healthy donors. Furthermore, expression DEGs evaluated by qRT-PCR. Finally, diagnostic power comparison to characteristics patients. In study, top five significantly...
Abstract Oral squamous cell carcinoma (OSCC) often recurs aggressively and metastasizes despite surgery adjuvant therapy, driven by postoperative residual cancer cells near the primary tumor site. An implantable in situ vaccine hydrogel was designed to target OSCC post‐tumor removal. This serves as a reservoir for sustained localized release of δ‐aminolevulinic acid (δ‐ALA), enhancing protoporphyrin IX‐mediated photodynamic therapy (PDT), polydopamine‐hyaluronic composite photothermal (PTT)....
Somatostatin receptors (SSTRs) exert critical biological functions such as negatively regulating hormone release and cell proliferation, making them popular targets for developing therapeutics to treat endocrine disorders, especially neuroendocrine tumors. Although several panagonists mimicking the endogenous ligand somatostatin are available, development of more effective safer somatostatinergic therapies is limited due a lack molecular understanding recognition regulation divergent SSTR...
Abstract Introduction: PD-1 and PD-L1antibodies have shown impressive clinical benefits to cancer patients. However, still a significant number of patients fail respond those checkpoint inhibitors. To understand the underlying mechanism, we performed genomic immune profiling both tumor tissues cytotoxic T cells isolated from syngeneic mouse xenograft models treated with in-house WuXi anti-mouse PD-1(WX-mPD-1) PD-L1 (WX-mPD-L1) antibodies. Material methods: Syngeneic melanoma cell lines,...
<p>Significantly mutated genes,promoters and UTRs of MMs.</p>
<p>Supplementary figures and figure legends. (Figure S1) Deregulation of genes within key affected signaling pathways in MM. S2) Validation the somatic SNV/InDels found POM121. S3) Copy number changes S4) Distribution SVs genetic events including breakage-fusion-bridges [BFBs] chromothripsis across chromosomes among all samples. S5) SV occurring between chromosome 5 12 MM023 MM065. S6) Fine structure BFBs S7) Comparison lesions mucosal melanoma. S8) copy alteration CDK4 TERT...
<p>GISTIC peaks identified in MMs.</p>
<p>Comparison between two primary samples and matched metastatic samples.</p>
<p>Pathway analysis in MM and comparison between CM.</p>
<div>AbstractPurpose:<p>Unlike advances in the genomics-driven precision treatment of cutaneous melanomas, current poor understanding molecular basis mucosal melanomas (MM) has hindered such progress for MM patients. Thus, we sought to characterize genomic landscape identify alterations with prognostic and/or therapeutic implications.</p>Experimental Design:<p>Whole-genome sequencing (WGS) was performed on 65 samples, including 63 paired tumor blood samples and 2...
<div>AbstractPurpose:<p>Unlike advances in the genomics-driven precision treatment of cutaneous melanomas, current poor understanding molecular basis mucosal melanomas (MM) has hindered such progress for MM patients. Thus, we sought to characterize genomic landscape identify alterations with prognostic and/or therapeutic implications.</p>Experimental Design:<p>Whole-genome sequencing (WGS) was performed on 65 samples, including 63 paired tumor blood samples and 2...
<p>Whole Genome Sequencing metrics and clinical data of MMs.</p>
<p>Distribution of chromothripsis and BFB correlation analysis the SV pattern CNV pattern.</p>
<p>Comparison between two primary samples and matched metastatic samples.</p>
<p>Distribution of chromothripsis and BFB correlation analysis the SV pattern CNV pattern.</p>