A5023592883- Curcumin's Biomedical Applications
- Cancer, Lipids, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- Seaweed-derived Bioactive Compounds
- Protein Hydrolysis and Bioactive Peptides
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Biological Stains and Phytochemicals
- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Musculoskeletal synovial abnormalities and treatments
- Bartonella species infections research
- Inflammasome and immune disorders
- Medical Research and Treatments
- Clostridium difficile and Clostridium perfringens research
- Vehicle Routing Optimization Methods
- Neutropenia and Cancer Infections
- Echinoderm biology and ecology
- Distributed and Parallel Computing Systems
- Food composition and properties
- Natural Antidiabetic Agents Studies
- Hematological disorders and diagnostics
Beijing Normal University - Hong Kong Baptist University United International College
2023-2024
Hong Kong Baptist University
2022-2024
Guilin University of Electronic Technology
2024
Third Affiliated Hospital of Sun Yat-sen University
2019-2022
Sun Yat-sen University
2017-2022
The First Affiliated Hospital, Sun Yat-sen University
2017-2020
The Seventh Affiliated Hospital of Sun Yat-sen University
2020
Brookhaven National Laboratory
2020
Suzhou Municipal Hospital
2013
Nanjing Medical University
2013
To identify new biomarkers of prostate cancer (PCa) for the diagnosis and prediction clinical outcomes. Existing microarray data PCa tissues in Oncomine database were analyzed candidate differentially expressed genes (DEGs) that may be novel noninvasive obtained. On this basis, plasma mRNA was extracted from patients healthy donors. Furthermore, expression DEGs evaluated by qRT-PCR. Finally, diagnostic power comparison to characteristics patients. In study, top five significantly...
In this study, network pharmacology, bioinformatics and molecular docking were used to explore the active phytochemicals, hub genes, potential mechanisms of Gleditsiae Spina in treating colorectal cancer..The targets Spina, related CRC derived from databases. We identified genes for anti-colorectal cancer following protein-protein-interaction (PPI) network. Furthermore, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyze a macro perspective. Finally, we verified by...
The anticancer properties of Laminaria japonica peptides (LJPs) have never been studied. Here, we extracted LJPs from fresh seaweed and explored their anti-liver cancer activity (in vivo in vitro). were isolated/purified by HPLC-ESI-MS. HepG2 cell apoptosis cycle evaluated. MTT assays used to examine the cytotoxicity LJPs. Caspase activation caspases 3 9, cleaved PARP was examined Western blotting. PI3K/AKT pathway phosphorylation states MAPKs (p38 JNK) examined. We found that LJP-1 peptide...
This study aims to identify the mechanism of geniposide regulating oxidative stress in colorectal cancer (CRC) through network pharmacology and bioinformatics analysis. Targets geniposide, stress-related targets related CRC were applied from databases. The hub genes for identified with protein–protein interaction (PPI) network. Furthermore, we Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyze a macro perspective. We verified by molecular docking, GEPIA, HPA...
Obesity is a chronic and complex disease defined by the excessive deposition of fat highly associated with oxidative stress. Adzuki bean saponins (ABS) showed anti-obesity activity in our previous vivo study; however, active adzuki beans potential mechanisms are still unclear. This research aims to elucidate effects ABS improving lipid metabolism stress, exploring effective ingredients molecular through UHPLC-QE-MS analysis, network pharmacology, bioinformatics, vitro experiments both 3T3-L1...
Depressive disorder (DD) is the leading cause of disability worldwide and most prevalent mood disorder. Accumulative evidence from epidemiological studies has shown that DD a risk factor for cancer. However, role molecular mechanism in hepatocellular carcinoma (HCC) are still unknown. In this study, 30 mice were randomly divided into two groups: HCC group HCC-DD group. The mouse model was established by induction with reserpine every other day monthly doses diethylnitrosamine (DEN). All...
In recent decades, a classic recipe in traditional Chinese medicine, Guilu erxian jiao (GEJ), has been used the prevention and treatment of myelosuppression following cancer chemotherapy. However, safety efficacy GEJ not studied. present study, we investigated management cohort advanced lung adenocarcinoma patients who received 4 cycles Treatment with was compared to conventional pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF). The group (38 patients) orally...
To mitigate the potential for conflicts among aircraft navigating on surface and enhance operational efficiency safety at airports, this study explores various types of taxiing between presents an A* algorithm model. This model considers both distance direction, aiming to achieve conflict-free taxiway scheduling. By minimizing overall duration flights, approach enhances efficiency. Simulation analyses are conducted with illustrative examples, indicating that proposed optimization method...
Large scientific data centers have recently begun providing a number of different types storage in order to satisfy the various needs their users. Users with interactive accounts, for example, might want POSIX interface easy access from machines. Grid computing sites, on other hand, likely need provide an X509-based protocol, like SRM and GridFTP, since management system is built upon them. Meanwhile, experiment producing large amounts typically demands service that provides archival safe...
A 76-year-old man with a 30-year history of gout was admitted for chronic renal failure and the articular pain at right foot. He noted to have multiple hard swelling. The swelling developed over 10 years, progressively increasing in size. Physical examination revealed that there were large firm tophi on hands, both olecranon processes, feet (Figure 1A). Figure 1. ( ) Multiple subcutaneous are seen feet. ( B 3D CT images foot demonstrating extensive (dorsal view). Laboratory...
Background: Little is known about the precise molecular mechanisms involved in progression of hepatocellular carcinoma (HCC). Cell division cycle-associated (CDCA) genes, consisting seven family members, are pivotal for cell mitosis and contribute to tumorigenesis a variety cancers. However, relationship between CDCA genes HCC have not been largely reported. Here, we aimed assess prognostic diagnostic value HCC.Methods: Multiple public databases integrating genetic, mRNA proteomic microarray...