A5100625250- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Hepatocellular Carcinoma Treatment and Prognosis
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Nutrition, Genetics, and Disease
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Enhanced Recovery After Surgery
- Wnt/β-catenin signaling in development and cancer
Sichuan Cancer Hospital
2022-2025
University of Electronic Science and Technology of China
2025
Soochow University
2023-2024
First Affiliated Hospital of Soochow University
2024
Air Force Medical University
2018-2024
Xijing Hospital
2018-2024
Central South University
2024
Fujian Medical University
2023-2024
Third Affiliated Hospital of Sun Yat-sen University
2016-2023
Sun Yat-sen University
2016-2023
In recent years, Bisphenol S (BPS) has increasingly been used as an alternative to A (BPA) in food, paper, and personal care products. It is imperative clarify the relationship between BPS tumors order treat prevent diseases. This study discovered a new method for predicting tumor correlations interactive genes. According analyses conducted by Gene Ontology Kyoto Encyclopedia of Genes Genomes, genes were primarily found gastric cancer. Based on gene-targeted prediction molecular docking,...
Objective: Multiple myeloma (MM) is an incurable haematological cancer characterized by abnormal proliferation of plasma cells.The promising therapeutic effect selective inhibitors nuclear export in MM reveals the broad prospects localization intervention.Sterol regulatory element binding protein 2 (SREBP2) a lipid molecule that has been implicated drug therapy for MM.SREBP2 reported to be regulated antimalarial artesunate (ART) through alteration its and shown inhibit ferroptosis other...
This study aimed to assess the efficacy and safety of a combination therapy Allisartan Isoproxil 240 mg Amlodipine 5 (ALI/AML) compared AML monotherapy in patients with mild-to-moderate essential hypertension. In this phase III, multicenter, double-blind, parallel-group, randomized controlled trial, aged 18-70 years mean sitting systolic blood pressure (msSBP) between 140 <180 mmHg diastolic (msDBP) 90 <110 mmHg, following 4-week treatment mg, were 1:1 receive either ALI/AML or once daily...
MicroRNAs (miRNAs) have been demonstrated to exhibit abnormal expression patterns in various types of human cancer. The aim the present study was identify a novel tumor suppressor microRNA (miR) and investigate its physiological function mechanism renal cell carcinoma (RCC). levels miRNA (miR)‑362‑3p expres were measured 47 pairs RCC adjacent normal tissue samples, using reverse transcription-quantitative polymerase chain reaction analysis. In addition, miR‑362‑3p transfected into cancer...
Latent metastasis of colorectal cancer (CRC) frequently develops months or years after primary surgery, followed by adjuvant therapies, and may progress rapidly even with targeted therapy administered, but the underlying mechanism remains unclear. Here, we aim to explore molecular basis for aggressive behavior latent in CRC. Transcriptional profiling pathway enrichment analysis paired metastatic tumor samples were performed. The mechanisms pleckstrin homology-like domain, family B, member 2...
Papillary renal cell carcinoma (pRCC) is one of the epithelial (RCC) histological subtypes. Ferroptosis a new iron-dependent form death that has been seen in variety clinical situations. Using differentially expressed ferroptosis-related long non-coding RNAs (lncRNAs) from patients with pRCC The Cancer Genome Atlas; we built prognostic lncRNA-based signature. We discovered seven different lncRNAs were strongly linked to prognosis pRCC. High-risk scores poor for pRCC, which was confirmed by...
The aim of the study was to validate expression protein tyrosine kinase 6 (PTK6) in nonsmall cell lung cancer (NSCLC), and evaluate its clinicopathological prognostic significance.We first conducted a meta-analysis on mRNA profiling data sets NSCLC Oncomine database. Then, one most significantly upregulated targets, PTK6, further validated by immunohistochemistry 104 primary tumors. Furthermore association between PTK6 expression, clinical parameters, overall survival analyzed.Using...
The purpose of this study was to determine the effect video-based nursing education on perioperative anxiety and depression. A total 128 patients scheduled for minimally invasive gastrectomy were randomly divided into intervention (n = 64) control group. The. depression scores, systolic blood pressure (SBP), diastolic (DBP), heart rate (HR) assessed before intervention, 1 h surgery 24 after surgery. And cortisol levels measured No significant difference observed in baseline score, vital...
Lung cancer is the leading cause of cancer-related death, with high morbidity and mortality rates due to lack reliable methods for diagnosing lung at an early stage. Low-dose computed tomography can help detect abnormal areas in lungs, but only 16% cases are diagnosed early. Tests markers often employed determine genetic expression or mutations carcinogenesis. Serum glycome analysis a promising new method diagnosis as glycopatterns exhibit significant differences patients. In this study, we...
BACKGROUND:Ubiquitin-specific peptidase 33 (USP33) is a deubiquitinase that balances the ubiquitin status of proteins. It has been reported to act as tumor suppressor in colorectal cancer and lung cancer. However, expression pattern clinical significance USP33 have not investigated gastric adenocarcinoma (GAC). MATERIAL AND METHODS:We explored protein RNA levels by immunohistochemistry (IHC), Western blot analysis, qRT-PCR. The Pearson chi-square test was performed evaluate statistical...
N-myc downstream-regulated gene 3 (NDRG3) is one of the important members NDRG family which crucially take part in cell proliferation, differentiation and other biological processes.In this present study, western-blotting analysis was performed to evaluate NDRG3 expression NSCLC lines. One-step quantitative reverse transcription-polymerase chain reaction (qPCR) with 16 fresh-frozen samples immunohistochemistry (IHC) 100 cases were conducted explore relationship between clinicopathological...
Rab27b is reported to associate with the development and progression of several types human cancers. However, relationship between expression clinical characteristics lung adenocarcinoma (LUAD) rarely explored. In this present study, TCGA database was consulted, followed by one-step quantitative reverse transcription polymerase chain reaction (qPCR), Western blot, immunohistochemistry (IHC) analyses in LUAD cell lines tissue samples. levels were statistically higher samples compared a...
Most patients with hepatocellular carcinoma (HCC) in China have been diagnosed spleen deficiency syndrome (SDS), which accelerates the progression of HCC by disrupting tumor microenvironment homeostasis. This study aimed to investigate intercellular crosstalk SDS. An HCC-SDS mouse model was established using orthotopic transplantation based on reserpine-induced Single-cell data analysis and cancer cell prediction were conducted Seurat CopyKAT package, respectively. Intercellular interactions...
<b><i>Background/Aims:</i></b> In recent years the diagnosis and management of renal cancer has changed greatly, although mechanism is still elusive. TMEM106a a conserved type II transmembrane protein which key factor to regulate macrophage activation. Its inactivation in gastric frequently observed be associated with poor prognosis. The role remained unclear. <b><i>Methods:</i></b> expression profiling was performed panel cell lines primary...
IntroductionEsophageal cancer is increasingly recognized as a significant global malignancy. The main pathological subtype of this esophageal squamous cell carcinoma (ESCC), which displays higher degree malignancy and poorer prognosis. Reactive oxygen species (ROS) play critical role in modulating the immune response to tumors, understanding regulation ROS ESCC could lead novel improved therapeutic strategies for patients.MethodsA consensus matrix derived from genes involved pathway revealed...
Cancer/testis (CT) antigens are promising targets for immunotherapy due to their restricted expression in the germ cells of testis healthy tissue and high immunogenicity. The aim present study was determine whether transmembrane protein 31 (TMEM31) is a CT antigen investigate pattern TMEM31 during progression melanoma. human mRNA multiple tissues determined through reverse transcription‑polymerase chain reaction analysis. analyzed testis, addition 128 primary melanoma 64 metastatic samples...
Hepatocellular carcinoma (HCC) is among the most malignant tumors with high recurrence and low 5-year survival rate. Lipid metabolism essential in tumor metastasis, although how altered lipid promotes HCC progression has not been well elucidated. Fat Storage Inducing Transmembrane Protein 2 (FITM2) a gene involved homeostasis cytoskeletal organization; however, its role regulating biological behavior evaluated.In this study, immunohistochemistry was performed to evaluate expression of FITM2...
Lung squamous cell carcinoma (LUSC) generally correlates with poor clinical prognoses due to the lack of available prognostic biomarkers. This study is designed identify a potential biomarker significant for prognosis and treatment LUSC, so as provide scientific basis decisions. Genomic changes in LUSC samples before after radiation were firstly discussed E2 factor (E2F) pathway significance. A series bioinformatics analyses statistical methods combined construct robust E2F-related gene...
The study aimed to explore the functional role of fibronectin type III domain containing 1 (FNDC1) in nonsmall cell lung cancer (NSCLC), as well mechanism governing its expression. expression levels FNDC1 and related genes tissue samples were detected by qRT-PCR. Kaplan-Meier analysis was employed analyze association between level overall survival NSCLC patients. Functional experiments such CCK-8 proliferation, colony formation, EDU staining, migration invasion assays conducted investigate...