A5101600160- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Particle accelerators and beam dynamics
- RNA Research and Splicing
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Superconducting Materials and Applications
- Particle Accelerators and Free-Electron Lasers
- Simulation and Modeling Applications
- Circular RNAs in diseases
- Cancer-related gene regulation
- Advanced Sensor and Control Systems
- RNA regulation and disease
- Speech and Audio Processing
- Spinal Cord Injury Research
- Recycled Aggregate Concrete Performance
- Diabetes and associated disorders
- Toxoplasma gondii Research Studies
- Diabetes Management and Research
- Lignin and Wood Chemistry
- Intracerebral and Subarachnoid Hemorrhage Research
- Geographic Information Systems Studies
- NF-κB Signaling Pathways
- Extenics and Innovation Methods
- Advanced Welding Techniques Analysis
Central South University
2016-2025
Affiliated Hospital of Guizhou Medical University
2024
Peking University
2023-2024
Second Affiliated Hospital of Nantong University
2022
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
Zhejiang University
2022
Qiqihar University
2022
Guangzhou Institute of Energy Conversion
2022
Affiliated Hospital of Nantong University
2022
Abstract Melanoma contributes a lot to skin cancer‐related deaths. lncRNAs are implicated in various diseases, including melanoma. lncRNA NEAT1 is frequently dysregulated and can play important roles multiple cancers. Nevertheless, little has been studied about the function of melanoma progression. In our present research, we displayed was overexpressed cells. A series functional assays showed that overexpression promoted proliferation, migration, invasion By contrast, knockdown obviously...
Whole genome transcriptomic analyses have identified a large number of long non-coding RNAs (lncRNAs), many which are involved in variety biological functions. However, their functions and molecular mechanisms associated with prostate cancer (PCa) progression to virulent androgen-independent (AI) form remain elusive. Herein, we investigated the lncRNA expression profiles indolent, androgen-dependent (AD) LNCaP cell line aggressive metastatic, AI C4-2 using microarray technology. The...
The tal-1 proto-oncogene encodes a helix-loop-helix DNA-binding protein that has been implicated in the formation of T cell acute lymphoblastic leukemia (T-ALL). Patients with T-ALL harbor structural rearrangements result from either local DNA deletion or t(1;14)(p34;q11) chromosome translocation. By analyzing chromosomes series patients, we have now identified discrete region wherein most translocation breakpoints occur. Moreover, mapping genomic revealed coding exons are situated on both...
Recent studies have shown that long noncoding RNAs (lncRNAs) profound impacts on cancer development. In our previous study, we confirmed lncRNA small nucleolar RNA host gene 16 (SNHG16) is associated with poor prognosis and malignant phenotype of gastric (GC). However, the bio logical function SNHG16 still unclear. Here, aimed to investigate mechanisms underlying roles in GC. this work, knockdown could inhibit epithelial-mesenchymal transition (EMT) invasion GC cells. Moreover, results...
Papillary renal cell carcinoma (pRCC) is one of the epithelial (RCC) histological subtypes. Ferroptosis a new iron-dependent form death that has been seen in variety clinical situations. Using differentially expressed ferroptosis-related long non-coding RNAs (lncRNAs) from patients with pRCC The Cancer Genome Atlas; we built prognostic lncRNA-based signature. We discovered seven different lncRNAs were strongly linked to prognosis pRCC. High-risk scores poor for pRCC, which was confirmed by...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, neuroinflammation, and endoplasmic reticulum (ER) stress. In recent years, exosomes have garnered significant attention as potential therapeutic tool for diseases. This study, the first time, investigates neuroprotective effects of derived from olfactory mucosa mesenchymal stem cells (OM-MSCs-Exos) in AD further explore role low-density lipoprotein receptor-related protein 1 (LRP1) this...
Abstract Background Exosome Lnc A2M-AS1 from olfactory mucosa mesenchymal stem cells (OM-MSCs) can ameliorate oxidative stress by improving mitophagy in cardiomuscular cells; however, it remains unclear whether this effect exists the brain tissues of patients with Parkinson’s disease (PD). Methods OM-MSC–Exosomes were isolated and verified based on morphology specific biomarkers. The effects OM-MSC-Exo mitochondrial autophagy, stress, lncRNA detected MPP + -treated HT22 cells. OM-MSC-Exos...
GHET1 is an oncogenic long noncoding RNA (lncRNA) that promotes the proliferation and invasion of many malignant cell types. However, function underlying mechanisms lncRNA in gastric cancer are not fully understood. In this study, expression was investigated it determined whether may potentially be used as a biomarker for disease. The lines MGC‑803 AGS were transfected with GHET1‑directed small interfering (siRNA) changes phenotype cell‑cycle‑related molecules assessed. downregulation...
Indoor positioning is the basic requirement of future services, and high-precision, low-cost indoor algorithms are key technology to achieve this goal. Different from outdoor maps, data has characteristic uneven distribution close correlation. In areas with low density, in order a high-precision effect, time will be correspondingly longer, but not necessary. The instability WiFi leads introduction noise when collecting data, which reduces overall performance system, so denoising very For...
In order to develop a new building material by recycling wasted concrete and expanded polystyrene (EPS), the EPS recycled concretes of different density were designed, their basic physical mechanical properties studied. The results show that concrete’s fluidity saturated bibulous rate increase with volume content. However, dry apparent density, compressive strength, split tensile strength thermal conductivity decrease linearly increased When content is 60%, cubic 4.0MPa its 0.27W/m•K....
Trajectory similarity measure is an important issue for analyzing the behavior of moving objects.In this paper, a method network constrained trajectories proposed.It considers spatial and temporal features simultaneously in calculating spatio-temporal distance.The crossing points semantic information trajectory are used to extract characteristic partition.Experiment results show that storage space decreased after partition valid efficient clustering.
The small nucleolar RNA host gene 16 (SNHG16) has recently been shown to be a putative oncogene in gastric cancer (GC) and other types, but how its four lncRNA variants are expressed any physiological pathological situation remains unknown. To investigate the expression function of SNHG16, mainly variant 1, GC, we performed quantitative PCR determine levels 60 GC tissue samples several cell lines. We also studied knocking down SNHG16 with siRNA affected proliferation, apoptosis, cycle...
Abstract Background In clinical practice, gastric cancer (GC) is a common malignancy with high morbidity. Accumulating research has revealed that lncRNAs are involved in the development and metastasis of tumor tissues multiple cancers. As reported, LINC00963, typical lncRNA aberrantly expressed cancer. However, underlying mechanisms super-enhancers mediating remain unclear. Materials methods The GC cell line enhancer-super-enhancer data were downloaded analyzed from NCBI database (GSE75595)....
The paper concerns a room-temperature cross-bar H-mode (CH) drift tube linac (DTL) with KONUS (Kombinierte Null Grad Struktur) [1,2] beam dynamics. To make the acceleration in DTL cell more efficient, we studied correlation between transit time factor (TTF) and structural coefficients, first. Furthermore, developed new code Python to demonstrate longitudinal dynamics clearly. computationally generates clusters, bunch centers, emittance growth single figure. Thus, stabilization region cluster...
Abstract Based on the design requirements proposed by Beijing On-Line Isotope Separation project (BISOL), four Sn 22+ -based, 81.25 MHz continuous wave (CW) drift tube linac (DTL) cavities have been designed. These DTLs are capable of accelerating 0.1 pmA from 0.5 MeV/u to 1.8 over a length 7 m, with an output longitudinal normalized RMS emittance 0.35 π ·mm·mrad, and transmission efficiency higher than 95%. The dynamics adopted KONUS (Kombinierte Null Grad Struktur Combined 0° Structure)...
It studies the optimization model of medicine-chest design. Given four different conditions design, it sets up a corresponding nonlinear, double objective to realize