A5043940905- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Cerebrovascular and Carotid Artery Diseases
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- Acute Lymphoblastic Leukemia research
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Chemotherapy-induced organ toxicity mitigation
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Cancer-related gene regulation
- Genomics, phytochemicals, and oxidative stress
- Cerebral Venous Sinus Thrombosis
- Lipid metabolism and biosynthesis
- Immune Cell Function and Interaction
- BRCA gene mutations in cancer
Guiyang Medical University
2018-2025
Affiliated Hospital of Guizhou Medical University
2019-2025
University of California, Davis
2019-2024
UC Davis Comprehensive Cancer Center
2019-2024
Nanyang Medical College
2013
This study aimed to investigate the regulatory effects of long non-coding RNA-ANRIL on CDKN2A in cell cycle Kasumi-1 cells and elucidate underlying molecular mechanisms. ANRIL expression levels were quantified using RT-qPCR peripheral blood samples from acute myeloid leukemia (AML) patients. knockdown efficiency was validated via RT-qPCR, distribution analyzed flow cytometry. Cell proliferation assays conducted with CCK-8 following palbociclib treatment downregulation. RNA...
α3β1 integrin is a promising cancer biomarker and drug target. We previously identified 9-amino-acid cyclic peptide LXY30 for detecting on the surface of live tumor cells. This study was undertaken to characterize in detection, cellular function, imaging, targeted delivery vitro vivo non-small cell lung (NSCLC) models. The whole-cell binding assay performed by incubating NSCLC cells, extracellular vesicles (EVs), peripheral blood mononuclear cells (PBMCs) with TentaGel resin beads coated...
Recent studies have shown that long noncoding RNAs (lncRNAs) profound impacts on cancer development. In our previous study, we confirmed lncRNA small nucleolar RNA host gene 16 (SNHG16) is associated with poor prognosis and malignant phenotype of gastric (GC). However, the bio logical function SNHG16 still unclear. Here, aimed to investigate mechanisms underlying roles in GC. this work, knockdown could inhibit epithelial-mesenchymal transition (EMT) invasion GC cells. Moreover, results...
Abstract There is an unmet clinical need to develop novel strategies overcome resistance tyrosine kinase inhibitors (TKI) in patients with oncogene-driven lung adenocarcinoma (LUAD). The objective of this study was determine whether simvastatin could TKI using the vitro and vivo LUAD models. Human cell lines, tumor cells, patient-derived xenograft (PDX) models from TKI-resistant were treated simvastatin, either alone or combination a matched TKI. Tumor growth inhibition measured by...
IL-35 is a potent immunosuppressive and anti-inflammatory cytokine, consisting of p35 subunit an Epstein-Barr virus-induced gene 3 (EBI3) subunit, which suppresses CD4+ effector T cell proliferation promotes regulatory (Treg) expansion. However, the effects on B cells (Bregs) in ankylosing spondylitis (AS) have not been explored. The present study aimed (i) to measure serum levels percentages Bregs peripheral blood patients with AS (ii) explore their relationships pathogenesis AS.A total 77...
Background: A long non-coding RNAs (LncRNAs) called antisense noncoding RNA in the INK4 locus (ANRIL), has emerged as substantial regulators of cell survival acute myeloid leukemia (AML). However, its speciffc and potential mechanism is uncertain AML. In this research, we investigated role ANRIL proliferation, apoptosis, underlying AML cells. Methods: expression was quantified by real-time quantitative polymerase chain reaction (RT-qPCR). Kasumi-1 cells were transfected with LV-ANRIL plasmid...
GHET1 is an oncogenic long noncoding RNA (lncRNA) that promotes the proliferation and invasion of many malignant cell types. However, function underlying mechanisms lncRNA in gastric cancer are not fully understood. In this study, expression was investigated it determined whether may potentially be used as a biomarker for disease. The lines MGC‑803 AGS were transfected with GHET1‑directed small interfering (siRNA) changes phenotype cell‑cycle‑related molecules assessed. downregulation...
We previously showed that α3β1 integrin is a novel cancer biomarker and drug target in non-small cell lung (NSCLC). This study characterized the α3 (ITGA3) expression on patient specimens.Tissue microarrays (TMAs) were prepared from archival tissue blocks containing 161 patients, which included 91 adenocarcinoma (LUAD), 46 squamous carcinomas (LUSC), 24 other histology types. TMA sections stained scored for ITGA3 by immunohistochemistry (IHC). Kaplan-Meier curves log-rank tests used to...
Introduction Immune checkpoint inhibitors (ICIs) only benefit a subset of cancer patients, underlining the need for predictive biomarkers patient selection. Given limitations tumor tissue availability, flow cytometry peripheral blood mononuclear cells (PBMCs) is considered noninvasive method immune monitoring. This study explores use spectrum cytometry, which allows more comprehensive analysis greater number markers using fewer cells, to identify potential and monitor ICI treatment in...
Gastric cancer (GC) remains a global disease with high mortality rate, the lack of effective treatments and toxicity side effects are primary causes for its poor prognosis. Hence, urgent efforts needed to find safe therapeutic strategies. Gypenoside (Gyp) is widely used natural product that regulates blood glucose improve progression few toxic effects. Given crucial role abnormal glycometabolism in driving tumor malignancy, it important explore association between Gyp GC understand mechanism...
Uncontrolled proliferation is an important cancer cell biomarker, which plays a critical role in carcinogenesis, progression and development of resistance to chemotherapy. An improved understanding novel genes modulating mechanism will help develop new therapeutic strategies. The nuclear factor erythroid 2-related 2 (Nrf2), transcription factor, decreases apoptosis when its expression upregulated. However, the relationship between Nrf2 Vincristine (VCR) chemotherapy B-cell acute...
The small nucleolar RNA host gene 16 (SNHG16) has recently been shown to be a putative oncogene in gastric cancer (GC) and other types, but how its four lncRNA variants are expressed any physiological pathological situation remains unknown. To investigate the expression function of SNHG16, mainly variant 1, GC, we performed quantitative PCR determine levels 60 GC tissue samples several cell lines. We also studied knocking down SNHG16 with siRNA affected proliferation, apoptosis, cycle...
Abstract Background In clinical practice, gastric cancer (GC) is a common malignancy with high morbidity. Accumulating research has revealed that lncRNAs are involved in the development and metastasis of tumor tissues multiple cancers. As reported, LINC00963, typical lncRNA aberrantly expressed cancer. However, underlying mechanisms super-enhancers mediating remain unclear. Materials methods The GC cell line enhancer-super-enhancer data were downloaded analyzed from NCBI database (GSE75595)....
<title>Abstract</title> Gastric cancer (GC) remains a global disease with high mortality rate, the lack of effective treatments and toxicity side effects are primary causes for its poor prognosis. Hence, urgent efforts needed to find safe therapeutic strategies. Gypenoside (Gyp) is widely used natural product that regulates blood glucose improve progression few toxic effects. Given crucial role abnormal glycometabolism in driving tumor malignancy, it important explore association between Gyp...
<div>Abstract<p>There is an unmet clinical need to develop novel strategies overcome resistance tyrosine kinase inhibitors (TKI) in patients with oncogene-driven lung adenocarcinoma (LUAD). The objective of this study was determine whether simvastatin could TKI using the <i>in vitro</i> and vivo</i> LUAD models. Human cell lines, tumor cells, patient-derived xenograft (PDX) models from TKI-resistant were treated simvastatin, either alone or combination a matched...
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