A5100387800- Cancer, Lipids, and Metabolism
- Sinusitis and nasal conditions
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- MicroRNA in disease regulation
- Psoriasis: Treatment and Pathogenesis
- Ferroptosis and cancer prognosis
- Otitis Media and Relapsing Polychondritis
- Dermatologic Treatments and Research
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Asthma and respiratory diseases
- Skin Protection and Aging
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Carcinogens and Genotoxicity Assessment
- Advancements in Transdermal Drug Delivery
- Neurological Complications and Syndromes
- PARP inhibition in cancer therapy
- Immune cells in cancer
- Neutropenia and Cancer Infections
- Nutrition and Health in Aging
- Diabetes and associated disorders
Soochow University
2021-2025
First Affiliated Hospital of Soochow University
2021-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Second Affiliated Hospital of Chongqing Medical University
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Sun Yat-sen University
2018-2023
Third Affiliated Hospital of Sun Yat-sen University
2018-2023
Shanghai Children's Medical Center
2023
Shanghai Jiao Tong University
2023
Abstract TGF-β1, upregulated in keloid tissue, promotes the proliferation, collagen formation and differentiation of dermal fibroblasts. miR-21 is one microRNAs first found human genome. The aim our study to explore mechanisms TGF-β1-induced scar fibroblasts proliferation transdifferentiation. In present study, we that TGF-β1 promoted transdifferentiation via up-regulating expression, which could be attenuated when was inhibited. Overexpression had similar effect as on Additionally,...
Reline, which is composed of choline chloride and urea in a molar ratio 1:2, the first most extensively studied deep eutectic solvent (DES). In certain applications, reline blended with organic solvents, dimethyl sulfoxide (DMSO) cases, to gain improved properties. Therefore, it crucial have profound understanding impact DMSO on dynamics structures species binary mixtures. this study, neat ten reline/DMSO mixtures, fraction ranging from 0.1 0.95, were investigated primarily through combined...
Abstract Dietary cholesterol has been implicated to promote lung cancer. Lung adenocarcinoma (LAC) is a main type of cancer, whereas the functional mechanism in LAC remained largely unknown. In present study, we evidenced that promoted cell proliferation and invasion vitro as well metastasis vivo. Cyp27A1 knockdown reduced cholesterol-induced cells invasion. contrast, Cyp7B1 enhanced effect on Furthermore, deficiency remarkably high Mechanism investigation demonstrated exposure...
Abstract Radioresistance was the main reason for local recurrence and metastasis of nasopharyngeal carcinoma. Tetrandrine is reported as an antitumor drug via inducing cell cycle arrest apoptosis. In this study, radiosensitization effects maximum noncytotoxic doses tetrandrine in carcinoma were analyzed both vitro vivo , using MTT assay, western blot, TUNEL, HE staining. It found that dose inhibited phosphorylation ERK MEK induced by irradiation, significantly enhanced irradiation‐induced...
In this study, a synthetic high-density lipoprotein (sHDL), peptide-based nanocarrier loaded with docetaxel (DTX) was constructed, against breast cancer. The thermodynamic and molecular dynamic analyses were conducted to examine the stability of nanoparticles synthesized from mimetic peptide 5 A various types phospholipids. Furthermore, cellular uptake in vivo fluorescence imaging analysis experiments, scavenger receptor B-I (SR-BI) carried out tumor-targeting ability sHDL. investigated for...
The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role in HCC progression its underlying mechanisms. Here we showed that expression was significantly reduced tissues compared paratumor tissues. Exogenous overexpression inhibited migration invasion cells, whereas downregulation able induce HepG2 SNU-449 invasion. In addition, lung an vivo mouse model, which is mainly regulated by...
Liver fibrosis and hepatocellular carcinoma (HCC) are common adverse consequences of chronic liver injury. The interaction various risk factors may cause them to happen. Identification specific biomarkers is great significance for understanding the occurrence, development mechanisms, determining novel tools diagnosis treatment both HCC.To identify fibrosis-related core genes, we analyzed differential expression pattern genes in HCC.Gene profiles three datasets, GSE14323, GSE36411, GSE89377,...
Background: Acute myeloid leukemia (AML) is a heterogeneous malignant disease. SLC25A1 , the gene encoding mitochondrial carrier subfamily of solute proteins, was reported to be overexpressed in certain solid tumors. However, its expression and value as prognostic marker has not been assessed AML. Methods: We retrieved RNA profile corresponding clinical data AML patients from Beat AML, TCGA, TARGET databases (TARGET_AML). Patients TCGA cohort were well-grouped into two group based on...
The aim of this study was to evaluate the effect TFR2 on iron storage in type 2 diabetes.A cross-sectional conducted among 1938 participants from Jiangchuan Community Shanghai. A total 784 with T2DM and 1154 normal (non-T2DM) were enrolled study. Serum ferritin, fasting blood glucose, postprandial HbA1C (glycated hemoglobin A1c) levels determined. Eighteen Wistar male rats randomly assigned into three groups (n = 6/group): a high-fat diet streptozotocin (HFD+STZ) group fed HFD for 4 weeks...
Background. Hypertrophic scar (HS) is a benign fibroproliferative skin disease resulting from an aberrant wound healing process and can cause aesthetic functional damage to patients. Currently, there no ideal treatment treat this disease. Galangin, natural active bioflavonoid compound, suggested inhibit fibrosis proliferation in certain cells. Methods. In study, we found Galangin could attenuate abnormal formation HS rabbit ear model. Additionally, the HE staining shows reduced elevation...
Abstract Background Eosinophilic chronic rhinosinusitis (ECRS) is predominantly characterized by nasal type 2 inflammation. The pathogenesis of this condition complex. High levels IL‐17A are associated with eosinophil infiltration in some inflammatory diseases and contribute to the severity insensitivity corticosteroid therapy for rhinosinusitis. Methods In first experiment, we constructed a modified ECRS mouse model using four groups mice: phosphate‐buffered saline (PBS)‐sensitized...
Non-alcoholic steatohepatitis (NASH) is a major contributor to liver cirrhosis and hepatocellular carcinoma. There remains no effective pharmacological therapy. The hepatic lipid metabolism fatty acid β-oxidation are regulated by Perilipin5 (Plin5). However, it yet unknown how Plin5 affects NASH the molecular process.High-fat, high-cholesterol high-fructose (HFHC) diets were used mimic progression of in wild type (WT) mice knockout (Plin5 KO) mice. degree ferroptosis was measured detecting...
As catabolic enzyme, CD73 dephosphorylates adenosine monophosphate (AMP) and can also regulate tumor cell proliferation metastasis. To date, very few studies have explored the role of in mediating non–small lung cancer (NSCLC) metastasis, underlying transducing signal has not been elucidated. In present study, we demonstrated that CD73/Axl axis could Smad3-induced epithelial-to-mesenchymal transition (EMT) to promote NSCLC Mechanically, be secreted via Golgi apparatus transport pathway. Then...