A5084084150- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Biochemical effects in animals
- Antioxidant Activity and Oxidative Stress
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- RNA Research and Splicing
Shanghai Jiao Tong University
2022-2025
Suzhou Kowloon Hospital
2025
Soochow University
2022-2024
Suzhou Research Institute
2024
First Affiliated Hospital of Soochow University
2022-2024
Gansu Provincial Hospital
2022
Peking Union Medical College Hospital
2022
Shanghai Ocean University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
First Affiliated Hospital of Zhengzhou University
2022
Adenanthin, a diterpenoid isolated from the leaves of Rabdosia adenantha, has anti-tumor activities. However, its role and mechanism in pancreatic cancer are unclear. This study aims to elucidate adenanthin induced death cells by regulating hydrogen peroxide (H2O2) reactive oxygen species (ROS) levels. Adenanthin was used detect cell activity on (Aspc-1) using Cell Counting Kit-8 (CCK-8) colony forming assays. Hoechst 33258 fluorescence staining flow cytometry related experiments were impact...
Long non-coding RNAs (LncRNA) play important roles in multiple types of cancers. We addressed the role LINC02535 by regulating miR-30a-5p /GalNAc Transferase 3 (GALNT3) axis to promote proliferation, migration, and invasion lung adenocarcinoma (LUAD) cells. The Cancer Genome Atlas (TCGA) database screened differentially expressed lncRNAs. Quantitative real-time PCR analysis (qRT-PCR) confirmed that is highly LUAD tissues In vitro experiments showed promotes A xenograft mouse model was used...
As catabolic enzyme, CD73 dephosphorylates adenosine monophosphate (AMP) and can also regulate tumor cell proliferation metastasis. To date, very few studies have explored the role of in mediating non–small lung cancer (NSCLC) metastasis, underlying transducing signal has not been elucidated. In present study, we demonstrated that CD73/Axl axis could Smad3-induced epithelial-to-mesenchymal transition (EMT) to promote NSCLC Mechanically, be secreted via Golgi apparatus transport pathway. Then...