A5070632299- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Frailty in Older Adults
- Metabolism, Diabetes, and Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Diet and metabolism studies
- Chronic Disease Management Strategies
- Neurological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- Circular RNAs in diseases
- Nutrition and Health in Aging
- Dialysis and Renal Disease Management
- Cancer Risks and Factors
- Chronic Kidney Disease and Diabetes
- Cognitive Functions and Memory
- Diabetes Management and Research
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Diabetes Treatment and Management
- MicroRNA in disease regulation
Tianjin Medical University
2015-2024
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2022-2024
Karolinska Institutet
2021-2023
Rush University Medical Center
2021-2023
Harbin Medical University
2014-2023
Illinois Institute of Technology
2023
Qilu Hospital of Shandong University
2021
Imperial College London
2021
Beijing Children’s Hospital
2021
Capital Medical University
2021
We suggest that a simple, rapid screening tool-the waist-to-height ratio (WHTR)-could help to overcome debates about the use of different body mass index (BMI) boundary values for assessing health risks in populations. There are six reasons our proposal: WHTR is more sensitive than BMI as an early warning risks. cheaper and easier measure calculate BMI. A value = 0.5 indicates increased risk men women. people ethnic groups. can be converted into consumer-friendly chart. may allow same...
China has been going through significant changes in social and economical aspects with great socioeconomic disparity different regions. However, data on the association between status (SES) obesity are not available Tianjin, China.This study aimed to investigate SES high adiposity among adult population Tianjin.A total of 7351 individuals aged 20-79 were included this study. Socioeconomic information was collected an interview following a structured questionnaire. Waist circumference, body...
The impact of cardiovascular risk burden on cognitive trajectories and brain structure changes remains unclear.This study aimed to examine whether assessed by the Framingham General Cardiovascular Risk Score (FGCRS) is associated with decline structural differences.Within Rush Memory Aging Project, 1,588 dementia-free participants (mean age: 79.5 years) were followed for up 21 years. FGCRS was at baseline categorized into tertiles (lowest, middle, highest). Episodic memory, semantic working...
Abstract Purpose: The therapeutic benefit of the cytokine-induced killer (CIK) cells was unknown in renal cell carcinoma (RCC). This prospectively randomized study conducted to evaluate effects autologous CIK immunotherapy patients with metastatic clear RCCs. Experimental Design: From June 2005 2008, 148 RCC were (arm 1, n = 74), or interleukin-2 treatment combination IFN-α-2a 2, 74). primary endpoint overall survival (OS) and secondary progression-free (PFS) evaluated by Kaplan–Meier...
Evidence on the association of lifespan cognitive reserve (CR) with dementia is limited, and strength this in presence brain pathologies unknown.
Background Although sleep disorders have been linked to cardiovascular diseases (CVDs), the association between characteristics and CVDs remains inconclusive. We aimed examine of nighttime duration, daytime napping, patterns with explore whether genetic early‐life environmental factors account for this association. Methods Results In Swedish Twin Registry, 12 268 CVD‐free twin individuals (mean age=70.3 years) at baseline were followed up 18 years detect incident CVDs. Sleep (assessed by...
Abstract Aims Early detection of diabetes is important for the prevention diabetic complications. The best adiposity index indicating Type 2 mellitus remains unclear. We aimed to identify optimal measure among BMI , waist circumference, waist–hip ratio and waist‐to‐height indicate undiagnosed impaired fasting glucose in Chinese adults. Methods A total 7567 participants aged 20–79 years were included this study. Impaired was defined as a plasma level 6.1–6.9 mmol/l without diabetes....
<h3>Background</h3> Gene amplification is a frequent manifestation of genomic instability that plays role in tumour progression and development drug resistance. It manifested cytogenetically as extrachromosomal double minutes (DMs) or intrachromosomal homogeneously staining regions (HSRs). To better understand the molecular mechanism by which HSRs DMs are formed how they relate to methotrexate (MTX) resistance, we used two model systems MTX-resistant HT-29 colon cancer cell lines harbouring...
The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and pathologies.
Evidence on the association of cognitive reserve (CR) with trajectories is limited. We aimed to examine influence CR indicator domain-specific taking brain pathologies into account.
Background It remains unclear whether cognitive reserve can attenuate dementia risk among people with different genetic predispositions. Aims We aimed to examine the association between and dementia, further explore what extent may modify effect of factors on dementia. Method Within UK Biobank, 210 631 dementia-free participants aged ≥60 years were followed detect incident Dementia was ascertained through medical death records. A composite indicator encompassing education, occupation...
Studies on the relationship between socio-economic status and Type 2 diabetes mellitus in Chinese population are sparse. We aimed to examine relation of as represented by income, education occupation impaired fasting glucose, diabetes, control a large population.This study included 7315 individuals who were aged 20-79 years living Tianjin, China. Impaired glucose ascertained according 1999 World Health Organization criteria. Data analysed using multinomial binary logistic regression, with...
Abstract Introduction The association of lifespan cognitive reserve (CR) with mild impairment (MCI) remains controversial. We aimed to examine the CR indicator risk MCI and its progression dementia, taking brain pathologies into account. Methods In a community‐based cohort study (mean age, 79 years) annual follow‐up (median, 5.16 years; maximum, 20 years), cognitively intact group (n = 1182) an 420) were identified at baseline. During follow‐up, 611 participants died underwent autopsies....
Abstract Introduction Whether depression is a prodromal phase or risk factor for dementia under debate. We aimed to unveil the nature of depression–dementia association by looking into time window occurrence. Methods Dementia‐free twins ( n = 41,727) from Swedish Twin Registry were followed‐up 18 years. Data analyzed using generalized estimating equation (GEE) all individuals and conditional logistic regression co‐twin matched pairs. Results In GEE model, multi‐adjusted odds ratios (ORs; 95%...
Abstract Tumor metastasis imposes metabolic requirements for escaping from primary tissues, producing vulnerability in treatment. This study aimed to explore the reprogramming relevant lung adenocarcinoma (LUAD) and decode underlying intercellular alterations. Using gene expression profiles of 394 LUAD samples derived The Cancer Genome Atlas (TCGA), we identified 11 metastasis-related genes involved glycolysis lipid metabolism, defined three phenotypes (MP-I, -II, -III) using unsupervised...
Abstract Background The relation between cigarette smoking and metabolic syndrome (MetS) remains unclear, previous studies focusing on MetS are limited in sample size. We investigated the association life-course with independent discovery replication samples. Methods Preliminary analysis utilized data from an annual cross-sectional survey of 15,222 participants aged ≥ 60 years Tianjin, China. Suggestive associations were followed-up 8565 adults China Health Nutrition Survey. was identified...
The association of motor function with cognitive health remains controversial, and the mechanisms underlying this relationship are unclear. We aimed to examine between long-term trajectories further explore using brain MRI.
OBJECTIVE Data on latent autoimmune diabetes in adults (LADA) from population-based studies are sparse. We sought to investigate the prevalence and correlates of LADA. RESEARCH DESIGN AND METHODS A total 8,109 participants, who were aged ≥15 years living Tianjin, China, assessed identify individuals with type 2 (American Diabetes Association Criteria, 1997) further detect patients LADA was ascertained by 1) presence age ≥35 years, 2) lack a requirement for insulin at least 6 months after...
Abstract Introduction The relationship between pulmonary function (PF) and mild cognitive impairment (MCI), dementia, brain pathologies remains unclear. Methods A total of 1312 dementia‐free participants, including a cognitively intact group (n = 985) an MCI 327), were followed for up to 21 years detect incident dementia. PF was assessed at baseline with composite score tertiled. Over follow‐up, 540 participants underwent autopsies neuropathological assessment. Results Compared the highest...