A5101513228- Sperm and Testicular Function
- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Reproductive Biology and Fertility
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Fermentation and Sensory Analysis
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Extracellular vesicles in disease
- Sexual function and dysfunction studies
- Phytochemicals and Antioxidant Activities
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Urinary Bladder and Prostate Research
- Neurological Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Food Quality and Safety Studies
- Neurological Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
Sun Yat-sen University
2019-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
Xinjiang Production and Construction Corps
2024
Shihezi University
2024
Tianjin Medical University
2011-2023
Kailuan General Hospital
2023
National Natural Science Foundation of China
2021
Science and Technology Commission of Shanghai Municipality
2021
Creative Commons
2021
This report systematically introduces the diagnosis and treatment guidelines of diabetic neuropathy which proposed by American Diabetes Association, including definition, classification, diagnostic criteria, clinical manifestations epidemiology peripheral neuropathy,how to screen earlier prevent, principles treatment. Key words: Diabetic neuropathy; Diagnosis; Treatment
To determine the effect of cofermentation
Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is potent immunosuppressive anti-inflammatory agent. So far, there no evidence regarding mechanism innate immune alterations celastrol on injury type 2 animal models. The present study was aimed at investigating protective effects rats elucidating possible involved mechanisms. We analyzed histopathological biochemical changes expressions TLR4 mediated signaling pathway. Compared to...
Male late-onset hypogonadism is an age-related disease, the core mechanism of which dysfunction senescent Leydig cells.Recent studies have shown that elimination cells can restore proper homeostasis to aging tissue.In present study, we found fork head box O (FOXO) transcription factor FOXO4 was specially expressed in human and its translocation nucleus elderly related decreased testosterone synthesis.Using hydrogen peroxide-induced TM3 as vitro model, observed maintains viability suppresses...
Stem cell therapies represent a promising new frontier for the treatment of refractory diabetic erectile dysfunction (DED). The use stem cell-derived extracellular vesicles (EVs) is novel strategy cell-free therapy. We have reported that urine-derived cells (USCs) can improve DED; however, therapeutic effects EVs secreted by USCs (USC-EVs) remain unknown.To determine USC-EVs on DED in rat model.USC-EVs were isolated from conditioned medium ultracentrifugation. was induced male Sprague-Dawley...
Abstract STUDY QUESTION Whether the testis-specific extracellular vesicle (EV) long noncoding RNAs (lncRNAs) in seminal plasma could be utilized to predict presence of testicular spermatozoa nonobstructive azoospermia (NOA) patients? SUMMARY ANSWER Our findings indicate that panel based on EV lncRNAs was a sensitive and specific method predicting may improve clinical decision-making NOA. WHAT IS KNOWN ALREADY The adoption sperm retrieval techniques, especially microdissection extraction...
OBJECTIVE Data on latent autoimmune diabetes in adults (LADA) from population-based studies are sparse. We sought to investigate the prevalence and correlates of LADA. RESEARCH DESIGN AND METHODS A total 8,109 participants, who were aged ≥15 years living Tianjin, China, assessed identify individuals with type 2 (American Diabetes Association Criteria, 1997) further detect patients LADA was ascertained by 1) presence age ≥35 years, 2) lack a requirement for insulin at least 6 months after...
Nonobstructive azoospermia (NOA) is a severe form of male infertility, with limited effective treatments. Urine-derived stem cells (USCs) possess multipotent differentiation capacity and paracrine effects, participate in tissue repair regeneration. The aim this study to investigate whether the transplantation USCs or USC exosomes (USC-exos) could promote endogenous spermatogenesis restoration busulfan-induced NOA mice model. were cultured characterized by flow cytometry. High-density hollow...
Cavernosal endothelial dysfunction is one of the factors in developing diabetic erectile (DED), but mechanism cavernosal unclear. The present study aimed at determining contribution autophagy DED rats and explaining therapeutic effect urine-derived stem cells (USCs). After rat corpus vascular (CCECs) were isolated cultured vitro, CCECs treated with advanced glycation end products (AGEs) to mimic situation. Autophagy flux, proliferation, apoptosis determined by mRFP-GFP-LC3 adenovirus...
Objective Since there is a paucity of reference data in the literature to indicate relationship between HbA1c, and 24 h mean blood glucose (MBG) from continuous monitoring (CGM) Chinese populations, we described above adult subjects with different tolerance status. Methods Seven-hundred-and-forty-two individuals without history diabetes were included study at 11 hospitals urban areas across China 2007–2009 673 into final analysis. Oral test (OGTT) classified participants as nondiabetic...
We aimed to evaluate the effects of intratunical injection exosomes derived from human urine-derived stem cells (USC-exo) on plaque formation and erectile function in a transforming growth factor-β1 (TGF-β1) induced Peyronie's disease (PD) rat model. Twenty-four SD rats were randomly assigned equally three groups: (I) Sham group (50 μl phosphate-buffered saline [PBS] injected into tunica albuginea [TA]), (II) PD (0.5 μg TGF-β1 50 PBS TA) (III) USC-exo ug plus 100 TA at same day). The maximum...
The elderly males undergo degenerative fertility and testicular endocrine function that jeopardize the reproductive health well-being. However, mechanisms underlying aging are unclear. Here, we tried to address this by investigating phenotypes transcriptomes of seven regions male mouse tract: testis, efferent ductules, initial segment, caput, corpus cauda epididymidis, vas deferens, in adult (3 months) aged (21 mice. Quantitative PCR, immunohistochemistry, immunofluorescent staining,...
Abstract The testicular spermatogenic epithelium, the fundamental functional unit of spermatogenesis, comprises Sertoli cells and a sequence cells, with Leydig playing pivotal supporting role in sperm development. In this study, we developed microfluidic organ-on-a-chip composed spermatogonial stem cells. After 28 days culture, demonstrated formation epithelial structure, observed proliferation differentiation Both were noted to perform their cellular functions engage intercellular...
Toll‑like receptor 4 (TLR4)‑mediated immune and inflammatory signaling serves a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Our previous study demonstrated that celastrol treatment was able to improve hepatic steatosis inhibit TLR4 cascade pathway type 2 diabetic rats. The present aimed investigate effects on triglyceride accumulation inflammation steatotic HepG2 cells, possible mechanisms responsible for regulation cellular responses following gene...
Male infertility is a major health issue with an estimated prevalence of 4.2% male worldwide. Oxidative stress (OS) one the main causes infertility, which characterized by excessive reactive oxygen species (ROS) or lack antioxidants. Meanwhile, it reported that oxidative plays important role in spermatogenic impairment Inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice. In this study, we focused on potential mechanism Guilingji protecting functions Immp2l The results revealed...
Male ageing is always accompanied by decreased fertility. The forkhead O (FOXO) transcription factor FOXO4 reported to be highly expressed in senescent cells. Upon activation, it binds p53 the nucleus, preventing cell apoptosis and maintaining cells situ. Leydig play key roles assisting spermatogenesis. senescence leads deterioration of microenvironment testes impairs In this study, we observed that FOXO4-DRI, a specific FOXO4- binding blocker, induced cells, reduced secretion certain...
An ideal animal model of azoospermia would be a powerful tool for the evaluation spermatogonial stem cell (SSC) transplantation. Busulfan has been commonly used to develop such model, but 30%–87% mice die when administered an intraperitoneal injection 40 mg kg−1. In present study, hematoxylin and eosin staining, Western blot, immunofluorescence, quantitative real-time polymerase chain reaction were test effects busulfan exposure in mouse that received two injections at 3-h interval different...