A5083286397- Dementia and Cognitive Impairment Research
- Genetic Mapping and Diversity in Plants and Animals
- Plant Pathogens and Fungal Diseases
- Nutritional Studies and Diet
- Health disparities and outcomes
- Nutrition and Health in Aging
- Diet and metabolism studies
- Chronic Disease Management Strategies
- Frailty in Older Adults
- Plant Disease Resistance and Genetics
- Mycorrhizal Fungi and Plant Interactions
- Dialysis and Renal Disease Management
- Metabolomics and Mass Spectrometry Studies
- Blood Pressure and Hypertension Studies
- MicroRNA in disease regulation
- Fungal Biology and Applications
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Wheat and Barley Genetics and Pathology
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Tea Polyphenols and Effects
- Cardiovascular Health and Risk Factors
- Genetic and phenotypic traits in livestock
Karolinska Institutet
2021-2025
China Agricultural University
2023-2025
Fudan University
2012-2025
Shanxi Agricultural University
2025
Shaanxi University of Chinese Medicine
2025
National Institute for Occupational Health and Poison Control
2025
Hebei Agricultural University
2025
Shandong University
2020-2025
Joint Genome Institute
2024-2025
Lawrence Berkeley National Laboratory
2024-2025
Periodontitis is a major chronic oral disease that accelerated by activation of the NLRP3 inflammasome and resulting pyroptosis. According to recent studies, active vitamin D its analogs have been reported great anti-inflammatory effects. However, mechanism newly found analog, eldecalcitol (ED-71), still unclear. This study investigates whether ED-71 could protect human gingival fibroblasts (HGFs) from LPS-induced pyroptosis and, if so, determine underlying mechanism.After HGFs were treated...
Cardiometabolic diseases (CMDs), including diabetes, heart disease, and stroke, are established risk factors for dementia, but their combined impact has been investigated only recently. This study aimed to examine the association between mid- late-life cardiometabolic multimorbidity dementia explore role of genetic background in this association.Within Swedish Twin Registry, 17 913 dementia-free individuals aged ≥60 were followed 18 years. CMDs [including age onset mid (60) or late (≥60)...
Micro- and nanoplastics (MNPs) homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, interaction between MNPs HMS its impact on HMS-induced EDEs remain unclear.
Importance Cardiovascular-kidney-metabolic (CKM) syndrome—a novel, multistage, multisystem disorder as defined by the American Heart Association—is highly prevalent in US. However, prevalence of CKM stages social determinants health (SDOH) remains unclear. Objective To investigate whether varies SDOH US adults. Design, Setting, and Participants This cross-sectional study used data from National Health Nutrition Examination Survey (1999-2018) included a nationally representative sample adults...
Importance Evidence on the associations of taste function changes from early adulthood to mid late with all-cause mortality is limited. Objective To investigate between subjective perception loss and mortality. Design, Setting, Participants This population-based cohort study used data US National Health Nutrition Examination Survey (2011-2014) linked information Death Index (NDI) included adults aged 40 years older. Data analyses were conducted May 6, 2024, July 22, 2024. Exposures...
Importance Body mass index (BMI) trajectories before the onset of mild cognitive impairment (MCI) and during progression from MCI to dementia remain unclear. Objective To assess long-term BMI preceding incident explore whether they are associated with brain pathologies. Design, Setting, Participants The Rush Memory Aging Project (MAP) was an ongoing community-based cohort study. This study included cognitively intact participants aged 60 90 years at baseline annual follow-up October 1997...
Abstract DNA N6-adenine methylation (6mA) has recently gained importance as an epigenetic modification in eukaryotes. Its function lineages with high levels, such early-diverging fungi (EDF), is of particular interest. Here, we investigated the biological significance and evolutionary implications 6mA EDF, which exhibit divergent patterns usage. The analysis two Mucorales species displaying extreme usage reveals that levels show symmetric enriched highly expressed genes. In contrast, low...
The association of motor function with cognitive health remains controversial, and the mechanisms underlying this relationship are unclear. We aimed to examine between long-term trajectories further explore using brain MRI.
Triclosan (TCS) has garnered significant attention due to its widespread use and associated endocrine-disrupting effects. However, impact on the neuroendocrine system underlying mechanisms remain poorly understood. Here, we established correlations between TCS exposure serum sex hormone levels in participants of National Health Nutrition Examination Survey (NHANES). Additionally, investigated TCS's influence using adult zebrafish exposed environmentally relevant concentrations (0.361–48.2...
The distribution of fat and muscle mass in different regions the body can reflect pathways to mortality individuals with diabetes. Therefore, we investigated associations between whole-body regional cardiovascular disease (CVD) non-CVD type 2 diabetes (T2D).
<h3>Background</h3> To evaluate the safety and efficacy of intralesional pingyangmycin for treatment orbital vascular malformations. <h3>Methods</h3> Thirteen patients received injections at Eye ENT Hospital Fudan University. CT scans each patient were evaluated with graphic processing software to measure lesion volumes before after treatment. <h3>Results</h3> Of five men eight women averaging 36 years old, six diagnosed venous malformations, cavernous haemangiomas, one lymphangioma....
Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer, which occurring at high frequency in Southern China. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical role carcinogenesis progression. In this study, we established comprehensive lncRNA profile NPC found 35 lncRNAs were differentially expressed NPC. We LINC0086 was decreased patient serum samples tissues. The KaplanMeier survival curve showed patients with expression had higher rate than those low...
The occurrence of parallel speciation strongly implies the action natural selection. However, it is unclear how general a phenomena since was only shown in small number animal species. In particular, adaptive process and mechanisms underlying remain elusive. Here, we used an integrative approach incorporating population genomics, common garden, crossing experiments to investigate wild rice species Oryza nivara from O. rufipogon. We demonstrated that originated multiple times different...
Cardiovascular health (CVH) has been associated with cognitive decline and dementia, but the extent to which CVH affects brain remains unclear. We investigated association of CVH, assessed using Life's Essential 8 (LE8), neuroimaging-based age brain-predicted difference (brain-PAD).
Hypertensive disorders during pregnancy are common complications in the second and third trimesters, characterized by clinical manifestations of hypertension, proteinuria, edema, one leading causes maternal mortality. This article summarizes research on treatment hypertensive with traditional Chinese medicine (TCM) recent years, focusing syndrome differentiation treatment, as well some external therapies, often combination Western medicine. The review primarily covers progress from...
Background Benign multiple sclerosis (MS), characterised by minimal disability despite long disease duration, remains poorly understood in terms of its determinants and prognostic implications. While lifestyle factors have been implicated modifying progression, their role distinguishing benign non-benign MS unclear. Methods We conducted a comparative analysis patients with (n=2040) (n=4283) using data from Swedish nationwide case-control studies long-term follow-up. Logistic regression...