A5103027471- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Endometriosis Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Advanced Nanomaterials in Catalysis
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Biochemical and Structural Characterization
- Aquaculture disease management and microbiota
- Birth, Development, and Health
- Neurofibromatosis and Schwannoma Cases
- RNA Interference and Gene Delivery
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Asthma and respiratory diseases
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Barrier Structure and Function Studies
- COVID-19 Impact on Reproduction
- Epigenetics and DNA Methylation
North Minzu University
2024
State Ethnic Affairs Commission
2024
Euler Technology (China)
2020-2024
Third Affiliated Hospital of Zhengzhou University
2015-2023
Bioscience (China)
2017-2022
China National Pharmaceutical Group Corporation (China)
2021
State Key Laboratory of Respiratory Disease
2019-2020
Guangzhou Medical University
2019-2020
Fujian Medical University
2020
Huazhong University of Science and Technology
2020
Abstract To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting total 1,782 plasma samples from 869 donors Wuhan, China and test specific antibody responses. The results show that positive rate IgG against receptor-binding domain spike protein (RBD-IgG) to severe acute respiratory syndrome 2 (SARS-CoV-2) COVID-19 exceeded 70% for 12 months post diagnosis. level RBD-IgG...
<h3>Background</h3> Gene amplification is a frequent manifestation of genomic instability that plays role in tumour progression and development drug resistance. It manifested cytogenetically as extrachromosomal double minutes (DMs) or intrachromosomal homogeneously staining regions (HSRs). To better understand the molecular mechanism by which HSRs DMs are formed how they relate to methotrexate (MTX) resistance, we used two model systems MTX-resistant HT-29 colon cancer cell lines harbouring...
Abstract Background Preeclampsia, one of the most lethal pregnancy-related diseases, is associated with disruption uterine spiral artery remodeling during placentation. However, early molecular events leading to preeclampsia remain unknown. Results By analyzing placentas from preeclampsia, non-preeclampsia, and twin pregnancies selective intrauterine growth restriction, we show that pathogenesis attributed immature trophoblast maldeveloped endothelial cells. Delayed epigenetic reprogramming...
Cuproptosis represents a novel class of cell death modality different from other regulated pathways. However, the role genes involved in copper-mediated within tumor microenvironment gastric adenocarcinoma remains to be elucidated. This study utilized R programming classify unprocessed information TCGA and GEO repositories individuals with stomach adenocarcinoma. Associations among various patient clusters, clinical factors, immune infiltration attributes, were assessed. Graphical displays...
Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by genome-wide search for differentially expressed genes human cancer tissues, metastases and normal tissues. MACC1 exerts an important role metastasis through upregulation of the c-Met proto-oncogene. The tyrosine kinase receptor encoded oncogene exhibits unusual property mediating invasive growth epithelial cells upon binding with hepatocyte factor (HGF). investigated regard to carcinoma expression...
Purpose: Recent evidence suggests that B cells can both promote and inhibit the development progression of allergic disease.However, characteristics cell subsets in patients with rhinitis (AR) have not been well documented.This study aimed to analyze peripheral blood AR patients.Methods: Forty-seven 54 healthy controls were enrolled this study, all subjects analyzed by flow cytometry.Moreover, serum total immunoglobulin E (IgE) IgE concentrations secreted into cultured mononuclear (PBMCs)...
Abstract Huge efforts have been devoted to develop therapeutic monoclonal antibodies targeting human Programmed death-ligand 1 (hPD-L1) for treating various types of cancers. However, thus far there is no suitable animal model evaluating the anti-tumor efficacy such against hPD-L1. Here we report generation a robust and effective system utilizing hPD-L1-expressing mouse tumor cells study activity mode action anti-human PD-L1 in mice. The has validated by using clinically proven hPD-L1...
Japanese encephalitis (JE) can infect many agriculturally important animals and humans, has a high incidence in Asia. One of the natural hosts mosquito-borne JE virus (JEV) is domestic pigs, which act as amplifier hosts. Porcine infection results fatal encephalitis, abortion, stillbirth pregnant sows, hypospermia boars. In this study, rapid JEV detection method for swine mosquitoes was developed based on reverse transcription loop-mediated isothermal amplification (RT-LAMP) targeting...
Since current subunit vaccines are limited by a short halflife <italic>in vivo</italic> and weak immune responses when used alone without adjuvants, there is an unmet need for combing carriers with complement activation signals to interrupt outbreaks in real-time.
Abstract Background The incidence of CHD is the highest among birth defects and increasing year to year. seriously harms health infants young children presents a large economic burden families society. pathogenesis preventive measures are focus current research. Our research aimed explore intervention effect folic acid on heart abnormalities resulting from sodium arsenic (NaAsO 2 ) exposure during periconception period. Methods Sixty 35-day-old female SD rats were randomly divided into 5...
Abstract To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting total 1,782 plasma samples from 869 donors Wuhan, China and test specific antibody responses. The results show that positive rate IgG against receptor-binding domain spike protein (RBD-IgG) to severe acute respiratory syndrome 2 (SARS-CoV-2) COVID-19 exceeded 70% for 12 months post diagnosis. level RBD-IgG...
Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It well-known as carriers play an important role in cell-cell communication through transporting many kinds bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore photodynamic anticancer therapy has...
Abstract Claudin-18 isoform 2 (CLDN18.2) is a member of the human claudin family tetraspan membrane proteins that are crucial structural and functional components tight junctions. Unlike other members, CLDN18.2 expression strictly limited to differentiated epithelial cells gastric mucosa. Interestingly was ectopically expressed at significant level in multiple tumor types including gastric, esophageal, pancreatic lung cancers, which makes it as an attractive anti-cancer target. TST001 novel...
To analyze relevant factors for recurrence of ovarian endometriosis after conservative surgery. A cohort study was performed on 310 patients who had surgery endometriosis. All underwent clinical interview. The included: age at surgery, symptom and signs, medical history, gynecologic examination, preoperative gravidity, complication, adenomyosis, American Society Reproductive Medicine (ASRM) scores, post-operative drug therapy, gravidity so on. logistic regression analysis to determine the...