A5025438590- RNA modifications and cancer
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- TGF-β signaling in diseases
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Cell Adhesion Molecules Research
- interferon and immune responses
- Microtubule and mitosis dynamics
- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- HIV Research and Treatment
- Retinoids in leukemia and cellular processes
- Folate and B Vitamins Research
- Genomics and Chromatin Dynamics
- NF-κB Signaling Pathways
- Kruppel-like factors research
- MicroRNA in disease regulation
Harbin Medical University
2016-2025
Ministry of Education of the People's Republic of China
2019-2025
Shenzhen University
2025
Shihezi University
2025
Laboratoire de Génétique Médicale
2011-2019
Laboratory of Molecular Genetics
2011-2019
Harbin University
2007-2012
University of Minnesota
2010
Third Affiliated Hospital of Harbin Medical University
2010
Fourth Affiliated Hospital of Harbin Medical University
2007
The human population has increased greatly in size the last 100,000 years, but initial stimuli to growth, times when expansion started, and their variation between different parts of world are poorly understood. We have investigated male demography East Asia, applying a Bayesian full-likelihood analysis data from 988 men representing 27 populations China, Mongolia, Korea, Japan typed with 45 binary 16 STR markers Y chromosome. According our analysis, northern examined all started expand...
Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB (IKK)/nuclear factor-kappaB (NF-kappaB) c-Jun N-terminal (JNK)/activator protein (AP-1) activation. Here we report that TNFalpha IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at Lys(158) residue within domain. Tumor receptor-associated factors 2 6 (TRAF2 -6) act as ubiquitin E3 ligases to mediate vivo vitro....
Abstract Extrachromosomal circular DNAs (eccDNAs) have been reported in most eukaryotes. However, little is known about the cell-free eccDNA profiles circulating system such as blood. To characterize plasma eccDNAs, we performed sequencing analysis 26 libraries from three blood donors and negative controls. We identified thousands of unique eccDNAs subjects. observed proportional increase with initial DNA input. The detected were also associated enrichment efficiency. Increasing depth an...
TAK1 (transforming growth factor-β-activated kinase 1), a mitogen-activated protein kinase, is activated by various cytokines, including interleukin-1 (IL-1). However, the precise regulation for activation at molecular level still not fully understood. Here we report that dual phosphorylation of Thr-178 and Thr-184 residues within loop essential TAK1-mediated NFκB AP-1 activation. Once co-overexpressed with TAB1, mutant alanine substitution these two fails to activate IKKβ-mediated...
<h3>Background</h3> Gene amplification is a frequent manifestation of genomic instability that plays role in tumour progression and development drug resistance. It manifested cytogenetically as extrachromosomal double minutes (DMs) or intrachromosomal homogeneously staining regions (HSRs). To better understand the molecular mechanism by which HSRs DMs are formed how they relate to methotrexate (MTX) resistance, we used two model systems MTX-resistant HT-29 colon cancer cell lines harbouring...
Purpose: Investigate the role of regulator chromosome condensation 2 (RCC2) on lung adenocarcinoma (LUAD) metastasis.Experimental Design: Clinical specimens were used to assess impact RCC2 LUAD metastasis. Mouse models, cytobiology, and molecular biology assays performed elucidate function underlying mechanisms in LUAD.Results: expression was frequently increased LUADs (88/122, 72.13%). It confirmed by analysis a larger cohort TCGA RNA-seq data containing 488 58 normal tissues (P < 0.001)....
Abstract Angiotensin II (Ang II) is a bioactive peptide of the renin–angiotensin system, acting not only as vasoconstrictor but also growth promoter via angiotensin type 1 receptor (AT1R) in some cancer. In this study, we examined mechanisms by which Ang affected cell proliferation AT1R‐positive MCF‐7 human breast cancer cells. stimulated cells dose‐ and time‐dependent manner. The maximal effect on was obtained with 10 −4 M at 24 h. Losartan (10 −5 M, an AT1R antagonist) significantly...
Gene amplification, which involves the two major topographical structures double minutes (DMs) and homegeneously stained region (HSR), is a common mechanism of treatment resistance in cancer initiated by DNA double-strand breaks. NHEJ, one DSB repair pathways, involved gene amplification as we demonstrated previously. However, involvement homologous recombination, another pathway, remains to be explored. To better understand association between HR detected activity DM- HSR-containing...
// Zhaoyu Liu 1, * , Lei Han 2, Yucui Dong Yanli Tan 3, Yongsheng Li 4 Manli Zhao 1 Hui Xie Huanyu Ju He Wang Yu Qifan Zheng Qixue 5 Jun Su 6 Chuan Fang 7 Songbin Fu 8 Tao Jiang 9 Jiaren 10 Xia Chunsheng Kang Huan Ren Department of Immunology, Harbin Medical University, 150081, China 2 Neurosurgery, Tianjin University General Hospital, 300052, 3 College Fundamental Medicine, Hebei Baoding 071000, Bioinformatics, Laboratory Neuro-Oncology, Neurological Institute, The Oncology Hospital...
Abstract Ovarian cancer is the most lethal gynecological malignancy worldwide with high metastasis and poor prognosis rates. Cancer‐associated fibroblasts (CAFs), a heterogeneous population of cells that constitutes major component tumor microenvironment, secrete extracellular vesicles (EVs) loading proteins, lipids, RNAs to promote tumorigenesis. However, specific roles CAF‐derived proteins contained in EVs ovarian remain poorly understood at present. Using gene expression microarray...
Aims: Alterations in calcium homeostasis the intracellular endo/sarcoplasmic reticulum (ER/SR) and mitochondria of cardiomyocytes cause cell death via SR mitochondrial apoptotic pathway, contributing to ventricular dysfunction. However, role calcium-sensing receptor (CaR) cardiac hypertrophy heart failure has not been studied. This study examined possible involvement CaR pathway an experimental model failure. Methods Results: In Wistar rats, were induced by subcutaneous injection...
Double minute chromosomes are cytogenetic manifestations of gene amplification frequently seen in cancer cells. Genes amplified on double include oncogenes and multi-drug resistant genes. These genes encode proteins which contribute to formation, progression, development resistance drugs used treatment. Elimination chromosomes, therefore them, is an effective way decrease the malignancy We investigated effectiveness a drug, gemcitabine, loss from ovarian cell line UACC-1598. Gemcitabine able...
Sphingosine kinase 2 (SphK2) as a conserved lipid has not been thoroughly elucidated in non-small cell lung cancer (NSCLC). The aim of the present study was to evaluate expression SphK2 NSCLC tissues and determine its correlation with clinicopathologic characteristics impact on patient prognosis. We assessed proliferating nuclear antigen (PCNA) (as proliferative index) by immunohistochemistry 180 patient's formalin-fixed paraffin-embedded tissue blocks. Relationship between PCNA various...