A5100421119- Neuroblastoma Research and Treatments
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Virus-based gene therapy research
- Computational Drug Discovery Methods
- Atherosclerosis and Cardiovascular Diseases
- Cancer Research and Treatments
- interferon and immune responses
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
- Spine and Intervertebral Disc Pathology
- Ubiquitin and proteasome pathways
- Ultrasound and Hyperthermia Applications
- Immune Response and Inflammation
- Microtubule and mitosis dynamics
- Autophagy in Disease and Therapy
- Chronic Myeloid Leukemia Treatments
- Calpain Protease Function and Regulation
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
Sichuan University
2025
Tsinghua University
2025
Nanjing University of Aeronautics and Astronautics
2024
Chinese Academy of Sciences
2009-2024
Shanghai Jiao Tong University
2015-2024
Shanghai Advanced Research Institute
2023-2024
University of Chinese Academy of Sciences
2020-2024
The University of Texas Southwestern Medical Center
2024
Westlake University
2024
Weifang Medical University
2024
We have explored the hypothesis that hypertrophy of vascular smooth muscle cells may be regulated, in part, by growth inhibitory factors alter pattern response to serum mitogens characterizing effects potent inhibitor, transforming factor-beta (TGF-beta), on both hyperplastic and hypertrophic cultured rat aortic cells. TGF-beta inhibited serum-induced proliferation (ED50 = 2 pM); this is consistent with previously reported observations bovine (Assoian et al. 1982. J. Biol. Chem....
Abstract Necroptosis, a form of programmed cell death, is characterized by the loss membrane integrity and release intracellular contents, execution which depends on membrane-disrupting activity Mixed Lineage Kinase Domain-Like protein (MLKL) upon its phosphorylation. Here we found myofibers committed MLKL-dependent necroptosis after muscle injury. Either pharmacological inhibition upstream kinase Receptor Interacting Protein Kinases 1 (RIPK1) or genetic ablation MLKL expression in led to...
Mercaptopurine (MP) and pro-drug azathioprine are 'first-line' oral therapies for maintaining remission in IBD. It is believed that their pharmacodynamic action due to a slow cumulative decrease activated lymphocytes homing inflamed gut. We examined the role of host metabolism, microbiome amelioration colitis by related thioguanine (TG).C57Bl/6 mice with or without specific genes altered elucidate mechanisms responsible TG's actions were treated daily intrarectal TG, MP water. Disease...
Abstract Calcium/calmodulin-dependent protein serine kinase (CASK) is a key player in vesicle transport and release neurons. However, its precise role, particularly nonneuronal systems, incompletely understood. We report that CASK functions as an important regulator of insulin secretion. depletion mouse islets/β cells substantially reduces secretion docking/fusion. forms ternary complex with Mint1 Munc18-1, this event regulated by glucose stimulation β cells. The crystal structure the...
Abstract How to effectively repair cutaneous wounds and promote skin rejuvenation has always been a challenging issue for clinical medicine medical aesthetics. Current conventional medicines exhibit several drawbacks, including limited therapeutic effects, prolonged treatment periods, high costs. As novel cell‐free therapy, the umbilical cord‐derived mesenchymal stem cell (UCMSC) secretome may offer promising approach regeneration rejuvenation. The UCMSC is collection of all proteins...
Abstract ALK receptor tyrosine kinase has been shown to be a therapeutic target in neuroblastoma. Germline activating mutations are responsible for the majority of hereditary neuroblastoma and somatic also frequently observed sporadic cases advanced NB. Crizotinib, first-line therapy treatment non-small cell lung cancer (NSCLC) harboring rearrangements, demonstrates striking efficacy against ALK-rearranged However, crizotinib fails effectively inhibit activity when present within its domain,...
Abstract Lung cancer stem cell ( LCSC ) is critical in initiation, progression, drug resistance and relapse. Disadvantages showed conventional lung therapy probably because of its existence. In this study, line A549 cells propagated as spheroid bodies (named sphere cells) growth factors‐defined serum‐free medium. displayed CSC properties, including chemo‐resistance, increased proportion G0/G1 cells, slower proliferation rate, ability differentiation enhanced tumour formation vivo . Oncolytic...
We previously identified a subcortical maternal complex (SCMC) that is essential for early embryogenesis and female fertility in mice. However, the molecular mechanism by which SCMC affects remains largely uncharacterized. Here, we report novel protein, zinc finger BED-type containing 3 (Zbed3), participates SCMC. Depletion of Zbed3 results reduced fecundity females, because impaired delayed development proportion mutant embryos. The loss asymmetric zygotic division abnormal distributions...
Broad-spectrum detection and long-term monitoring of circulating tumor cells (CTCs) remain challenging due to the extreme rarity, heterogeneity, dynamic nature CTCs. Herein, a dual-affinity nanostructured platform was developed for capturing different subpopulations CTCs during treatment. Stepwise assembly fibrous scaffolds, ligand-exchangeable spacer, lysosomal protein transmembrane 4 β (LAPTM4B)-targeting peptide creates biomimetic, stimuli-responsive, multivalent-binding nanointerfaces,...
Tumor-associated endothelial cells (TECs) limit antitumor immunity via inducing apoptosis of infiltrating T lymphocytes through a Fas ligand (FasL) mediated mechanism. Herein, this work creates peptide-drug conjugate (PDC) by linking 7-ethyl-10-hydroxycamptothecin (SN38) to hydrophilic segments with either RGDR or HKD motif at their C-terminus glutathione-responsive linker. The PDCs spontaneously assemble into filaments in aqueous solution. PDC containing 1% SN38-RGDR (SN38-HKD/RGDR)...
Objective In China, patients requiring intensive rehabilitation often face a gap between acute treatment and sub-acute rehabilitation. This study evaluates the composition determinants of post-acute hospitalization costs in stroke with disorders consciousness (DoC). Methods Data from 133 DoC who underwent inpatient at tertiary hospital 2015 to 2020 were collected, including demographic characteristics, clinical features, costs. Descriptive statistical analysis univariate performed, followed...
Immune checkpoint inhibitors are increasingly being utilized for the treatment of advanced neoplastic disease, and Sintilimab as a selective anti–PD-1 antibody that inhibits interactions between PD-1 its ligand, is typical representative them. Among all adverse effects(AEs) sintilimab, skin AEs had affected many people. Though exceedingly rare, eruptive keratoacanthomas-like lesion have been associated with use immune before. Here, we report case numerous keratoacanthoma-like lesions arising...
Background This study aims to compare hospitalization costs between traumatic brain injury (TBI) and non-traumatic (non-TBI) patients with disorders of consciousness (DoC) explore cost determinants. Methods A retrospective analysis was conducted on 210 DoC inpatients admitted Shenzhen Longcheng Hospital, a tertiary rehabilitation hospital located in China’s Pearl River Delta region, 2015 2020. Patients were categorized into TBI ( n = 44) non-TBI 166) groups based etiology. Demographic,...
Thioridazine (TDZ), originally an anti-psychotic drug, suppresses several types of cancer and has specificity for leukemia stem cells. The present study was performed to assess its effect on lung stem‑like cells, as remains unknown. TDZ utilized treat cells (A549 sphere cells) cytotoxic mechanism were evaluated in vitro vivo. elicited cytotoxicity A549 inhibited their proliferation a dose‑dependent pattern. treated with showed nuclear fragmentation, increased G0/G1 phase distribution,...
The aim of this study is to explore the expression CD109 in breast cancer stem cells and relationship between protein clinicopathological characteristics cancer. CD44+/CD24− tumor (CSCs) were selected by flow cytometry. was analyzed immunohistochemistry staining, parameters determined. positively regulated proliferation CSCs vitro, significantly higher triple-negative (TNBC) compared non-TNBC (63.78 vs. 3.71 %, P = 0.001). Moreover, related histological grade (P 0.015), whereas age 0.731),...
Kinesins play a key role in the development and progression of many human cancers. The present study investigated expression clinical significance kinesin family member 26B (KIF26B) colorectal cancer (CRC).Using quantitative real-time PCR Western blot analyses as well immunohistochemical staining tissue microarray we examined KIF26B mRNA protein levels CRC tumor tissues paired adjacent normal mucosa. Moreover, effect knockdown on cell proliferation was using Cell Counting Kit-8...
Abstract Neuroblastoma (NB) is the most common extracranial tumor in children. Unlike adult tumors, suppressor protein 53 (p53) mutations occur with a relatively low frequency NB and downstream function of p53 intact cell lines. Wip1 negative regulator hindrance activity by novel inhibitor GSK2830371 potential strategy to activate p53’s suppressing NB. Yet, vivo efficacy possible mechanisms have not yet been elucidated. Here we report that induced Chk2/p53-mediated apoptosis cells...