A5077445375- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Analytical chemistry methods development
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Advanced Photocatalysis Techniques
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Sensors
- Extracellular vesicles in disease
- Acoustic Wave Resonator Technologies
- Electrocatalysts for Energy Conversion
- Advanced Biosensing Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Microbial Community Ecology and Physiology
- Mass Spectrometry Techniques and Applications
- Supramolecular Self-Assembly in Materials
- Dendrimers and Hyperbranched Polymers
- Adenosine and Purinergic Signaling
- Antibiotics Pharmacokinetics and Efficacy
- Crystallization and Solubility Studies
Chinese Academy of Sciences
2016-2025
Beijing National Laboratory for Molecular Sciences
2016-2025
University of Chinese Academy of Sciences
2016-2025
Hubei University of Technology
2025
Research Center for Eco-Environmental Sciences
1999-2025
Institute of Vegetables and Flowers
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Foshan University
2022-2024
Fujian Medical University
2019-2024
Abstract Graphitic carbon nitride (g‐C 3 N 4 ) has been used as photosensitizer to generate reactive oxygen species (ROS) for photodynamic therapy (PDT). However, its therapeutic efficiency was far from satisfactory. One of the major obstacles overexpression glutathione (GSH) in cancer cells, which could diminish amount generated ROS before their arrival at target site. Herein, we report that integration Cu 2+ and g‐C nanosheets (Cu –g‐C led enhanced light‐triggered generation well depletion...
For the development of multistimuli responsive organogels, new organic gelator LMWG 1, featuring electroactive TTF and photoresponsive azobenzene groups, was designed studied. By manipulating redox state group in gel−sol transition for organogels with 1 can be reversibly tuned by either chemical or electrochemical oxidation/reduction reactions. Alternatively, photoisomerization also trigger transition. Therefore, respond not only to thermal stimuli but reactions light irradiation.
A new red-emissive bioprobe TPE-red-2AP2H was developed by taking advantage of the unique emission feature tetraphenylethylene and a cancer cell-specific peptide. By responding to target protein acidic microenvironment tumor cells, activated fluorescence bioimaging achieved with high signal-to-noise ratio without involving mutiple washing steps. Apart from targeting membrane-anchored LAPTM4B proteins, successfully utilized trace intracellular movement protein. The generation 1O2 under...
Prodrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half-lives of activating enzymes in bloodstream has limited its success. Demonstrated here that a tyrosinase-MOF nanoreactor activates prodrug paracetamol cells long-lasting manner. By generating reactive oxygen species (ROS) depleting glutathione (GSH), product enzymatic conversion toxic...
Silver nanoparticles (AgNPs) have been used as a broad-spectrum antimicrobial agent, whose toxicity originates from the localized release of Ag+ ions. However, residual AgNPs core could generate potential risk to humans and waste noble metals. Herein, we infused cysteine-modified molybdenum disulfide with minimum ions coated layer cationic polyelectrolyte construct an efficient benign depot. The system exhibited much enhanced antibacterial activity compared equivalent amount silver nitrate,...
Herein, a new fluorescence turn-on chemosensor 2-(4-(1,2,2-triphenylvinyl)phenoxy)acetic acid (TPE-COOH) specific for Al3+ was presented by combining the aggregation-induced-emission (AIE) effect of tertaphenylethylene and complexation capability carboxyl. The introduction carboxylic group provides probe with good water-solubility which is important analyzing biological samples. recognition toward induced molecular aggregation activated blue TPE core. high selectivity demonstrated...
Abstract The controlled synthesis of multicomponent metal–organic frameworks (MOFs) allows for the precise placement multiple cooperative functional groups within a framework, leading to emergent synergistic effects. Herein, we demonstrate that turn‐on fluorescence sensors can be assembled by combining fluorophore and recognition moiety complex cavity MOF. An anthracene‐based fluorescent linker hemicyanine‐containing CN − ‐responsive were sequentially installed into lattice PCN‐700....
Abstract Graphitic carbon nitride (g‐C 3 N 4 ) has been used as photosensitizer to generate reactive oxygen species (ROS) for photodynamic therapy (PDT). However, its therapeutic efficiency was far from satisfactory. One of the major obstacles overexpression glutathione (GSH) in cancer cells, which could diminish amount generated ROS before their arrival at target site. Herein, we report that integration Cu 2+ and g‐C nanosheets (Cu –g‐C led enhanced light‐triggered generation well depletion...
Abstract Tuning autophagy in a controlled manner could facilitate cancer therapy but it remains challenging. Pyridinium‐substituted tetraphenylethylene salts (PTPE 1 — 3 ), able to target mitochondria and disrupt after forming complexes with albumin, are reported. Mitochondrion affinity autophagy‐inducing activity improved by prolonging the length of alkyl chains PTPE – . demonstrate proautophagic mitophagy blockage effect. Failure autophagosome–lysosome fusion downstream flux results cell...
The superparamagnetic surface molecularly imprinted Fe3O4@MIP nanoparticles for bisphenol A (BPA) were prepared via initiated atom transfer radical polymerization (si-ATRP). Fe3O4 core was compactly encapsulated with a polychloromethylstyrene (PCMS) layer viamini-emulsion polymerization. exhibited property saturation magnetization of 25.2 emu g−1. BPA revealed specific selectivity and high affinity to the template over structural analogues. Moreover, surface-imprinted MIP showed good site...
Smart molecular probes and flexible methods are attracting remarkable interest for the visualization of cancer-related biological chemical events. In this work, a new fluorescence turn-on probe with dual-recognition characteristics specific imaging cancer cells is reported. This bioprobe rationally designed by linking tetraphenylethylene (TPE), an aggregation-induced emission (AIE) fluorophore, small peptide IHGHHIISVG (referred to as AP2H), targeting ligand broad-spectrum protein LAPTM4B....
Chemotherapeutics specifically targeting cancer cells without damaging healthy is the long-awaited goal of treatment. In this paper, a series nanoparticles (NanoTPES 1-4) assembled from pyridinium-substituted tetraphenylethylene salts were synthesized and investigated both in vitro vivo for purpose. By changing counter anions, NanoTPES 1-4 exhibit tunable emission colors, sizes surface charges. 2 3 with tetraphenyl borate tetra(4-chlorophenyl) as respective anions selectively imaged targeted...
Abstract Prodrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half‐lives of activating enzymes in bloodstream has limited its success. Demonstrated here that a tyrosinase‐MOF nanoreactor activates prodrug paracetamol cells long‐lasting manner. By generating reactive oxygen species (ROS) depleting glutathione (GSH), product enzymatic conversion...
Understanding the key factors for successful subcellular compartment targeting cargo delivery systems is of great interest in a variety fields such as bionanotechnology, cell biology, and nanotherapies. However, fundamental basis intracellular transportation with these has thus far rarely been discussed. As vector, porous coordination cages (PCCs) have potential use cancer nanotherapy to elucidate insight regarding targeting. Herein, it shown that PCC vectors though various barriers...
Smart and versatile nanostructures have demonstrated their effectiveness for biomolecule analysis show great potential in digging insights into the structural/functional relationships. Herein, a nanoscale molecular self-assembly was constructed probing site-specific recognition conformational changes of human serum albumin (HSA) with tunable size emission. A tetraphenylethylene derivative TPE-red-COOH used as building block tailoring fluorescence-silent nanoparticles. The highly specific...
Intracellular monitoring of protein ubiquitination and differentiating polyubiquitin chain topology are crucial for understanding life processes drug discovery, which is challenged by the high complexity process a lack molecular tools. Herein, synthetic dual-sensor platform specific K48-linked ubiquitin oligomers was tailored in situ visualization assembling live biosystems. This achieved using macrocyclic peptides as recognition motifs tetraphenylethylene derivative an activatable reporter....