A5100332247- Plant-derived Lignans Synthesis and Bioactivity
- Extracellular vesicles in disease
- Phytochemistry and Bioactivity Studies
- Advanced biosensing and bioanalysis techniques
- Traditional and Medicinal Uses of Annonaceae
- Water Quality Monitoring and Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Lipid Membrane Structure and Behavior
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Plant Toxicity and Pharmacological Properties
- Pneumonia and Respiratory Infections
- RNA Interference and Gene Delivery
- Hedgehog Signaling Pathway Studies
- Toxin Mechanisms and Immunotoxins
- Gold and Silver Nanoparticles Synthesis and Applications
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Diet, Metabolism, and Disease
- Biosensors and Analytical Detection
- Nanoparticle-Based Drug Delivery
- Phytochemical compounds biological activities
- Ubiquitin and proteasome pathways
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2021-2025
Beijing National Laboratory for Molecular Sciences
2024-2025
Wuhan Botanical Garden
2021-2023
Shanghai Institute of Materia Medica
2022
Lanzhou University of Technology
2010-2011
Lanzhou Petrochemical Polytechnic
2007
Intracellular monitoring of protein ubiquitination and differentiating polyubiquitin chain topology are crucial for understanding life processes drug discovery, which is challenged by the high complexity process a lack molecular tools. Herein, synthetic dual-sensor platform specific K48-linked ubiquitin oligomers was tailored in situ visualization assembling live biosystems. This achieved using macrocyclic peptides as recognition motifs tetraphenylethylene derivative an activatable reporter....
Here, we present a high-quality chromosome-scale genome assembly (2.19 Gb) and annotation of Tetrastigma hemsleyanum, perennial herbaceous liana native to subtropical China with diverse medicinal applications. Approximately 73% the was comprised transposable elements (TEs), which long terminal repeat retrotransposons (LTR-RTs) were predominant group (69% genome). The size increase T. hemsleyanum (relative Vitis species) mostly due proliferation LTR-RTs. Of different modes gene duplication...
Abstract Cyclocarya paliurus has been widely applied for therapeutic feeding as a traditional Chinese medicine homologous food with high nutritional and medical value. Nevertheless, the specific bioactive compounds liable hypoglycemic hypolipidemic properties underlying mechanisms remain unexplored. In present study, in vitro effects of C. were assessed by α‐glucosidase pancreatic lipase inhibition assays, results indicated that 70% ethanol extract exhibited remarkable inhibitory activity IC...
Podophyllum sinense (P. sinense) has been used as a traditional herbal medicine for ages due to its extensive pharmaceutical activities, including antiproliferative, anti-inflammatory, antiviral, insecticidal effects, etc. Nevertheless, the specific bioactive constituents responsible and antiviral activities remain elusive, owing complicated diversified chemical components. In order explore these components their potential interaction targets, affinity ultrafiltration with multiple drug...
High-performance isolation of exosomes as a promising liquid biopsy target is great importance for both fundamental research and clinical applications. This is, however, challenged by the prevalent heterogeneity highly complex nature biosamples. Here, we introduce use CD81-targeting peptide building block tailoring molecular baits exosome payload analysis in biofluids. To explore full potential multivalent interactions, peptide-functionalized affinity interfaces were covalently engineered...
Dysosma versipellis (D. versipellis) and Phyllanthus urinaria (P. urinaria) are two typical Chinese herbs with diverse chemical composition affluent pharmacological activities. Yet, the specific bioactive components anti-inflammatory anti-viral effects corresponding mechanisms remain unclear. The aim of this study was to screen for constituents activities from anti-HBV formulation. D. versipellis, P. formulation extracts were evaluated by in vitro ACE2 COX-2 inhibitory assays. Affinity...
: Sinopodophyllum hexandrum (S. hexandrum) is a typical Chinese herbal medicine with multiple components and pharmacological activities. However, the specific phytochemicals responsible for its anti-proliferative, anti-inflammatory anti-viral effects remain unexplored. This study aimed to explore bioactive from S. remarkable in an effort construct decipher empirical therapeutic roles. Bio-affinity ultrafiltration (AUF) drug targets corresponding activities was developed screen potential...
Background: Dysosma versipellis (D. versipellis) has been traditionally used as a folk medicine for ages.However, the specific phytochemicals responsible their correlated anti-inflammatory, anti-proliferative and antiviral activities remain unknown.Purpose: This study aimed to explore active components in D. its potential anti-proliferative, effects, further elucidate corresponding mechanisms of action.Methods: Bioaffinity ultrafiltration coupled liquid chromatography-mass spectrometry...
This paper reported the synthesis of a new flocculant, carboxymethyl guar through rapid semidry process, using natural gum as basic material. The factors which affect degree substitution (DS) guar, such reaction temperature, time, consumption chloroacetic acid, and sodium hydroxide etc were studied. best condition was concluded. flocculating property produced flocculant experiment results showed that turbidity ratio micro-polluted water better than other flocculants. synthetic should have...
Abstract Background: Sinopodophyllum hexandrum ( S. ) is a typical Chinese herbal medicine with numerous components and remarkable pharmacological activities. However, the specific phytochemicals responsible for its anti-proliferative, anti-inflammatory anti-viral effects remain unexplored. Methods: The integrated analytical strategy combining bio-affinity ultrafiltration multiple drug targets was developed to rapidly screen identify bioactive ligands from . in vitro anti-proliferative COX-2...