A5100341133- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Shoulder Injury and Treatment
- Pediatric Pain Management Techniques
- Diversity and Career in Medicine
- Lung Cancer Research Studies
- Anesthesia and Pain Management
- Cancer therapeutics and mechanisms
- Esophageal and GI Pathology
- Ubiquitin and proteasome pathways
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Renal and related cancers
- Shoulder and Clavicle Injuries
- Cancer-related Molecular Pathways
- Tracheal and airway disorders
- Global Health Workforce Issues
- Signaling Pathways in Disease
- Sarcoma Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Soft tissue tumor case studies
- Congenital Diaphragmatic Hernia Studies
- Central Venous Catheters and Hemodialysis
- Immune cells in cancer
Korea University
2010-2025
Children's Hospital of Los Angeles
2015-2024
University of Southern California
2015-2024
Kangbuk Samsung Hospital
2016-2024
Cedars-Sinai Medical Center
2023-2024
Sungkyunkwan University
2010-2024
Scripps College
2024
Children's Cancer Center
2009-2023
The University of Texas at Austin
2023
Sinai Health System
2023
While surgeons often delay pregnancy and childbearing because of training establishing early careers, little is known about risks infertility complications among female surgeons.To describe the incidence in US to identify workplace factors associated with increased risk compared a sociodemographically similar nonsurgeon population.This self-administered survey questionnaire was electronically distributed collected from November 2020 January 2021 through multiple surgical societies social...
Vascular endothelial growth factor (VEGF) plays a key role in human tumor angiogenesis. We compared the effects of inhibitors VEGF with different specificities xenograft model neuroblastoma. Cultured neuroblastoma NGP-GFP cells were implanted intrarenally nude mice. Three anti-VEGF agents tested: an anti-human 165 RNA-based fluoropyrimidine aptamer; monoclonal antibody; and VEGF-Trap, composite decoy receptor based on VEGFR-1 VEGFR-2 fused to Fc segment IgG1. A wide range efficacy was...
Neuroblastoma (NB) is a common pediatric cancer and contributes to more than 15% of all cancer-related deaths. Unlike adult tumors, recurrent somatic mutations in NB, such as tumor protein 53 (p53) mutations, occur with relative paucity. In addition, p53 downstream function intact NB cells wild-type p53, suggesting that reactivation may be viable therapeutic strategy for treatment. Herein, we report the ubiquitin-specific protease 7 (USP7) inhibitor, P22077, potently induces apoptosis an...
Vα24-invariant NKT cells inhibit tumor growth by targeting tumor-associated macrophages (TAMs). Tumor progression therefore requires that TAMs evade cell activity through yet-unknown mechanisms. Here we report a subset of in neuroblastoma (NB) lines and primary tumors expresses membrane-bound TNF-α (mbTNF-α). These proinflammatory induced production the chemokine CCL20 from via activation NF-κB signaling pathway, an effect was amplified hypoxia. Flow cytometry analyses human NB revealed...
Immunotherapy of high-risk neuroblastoma using the anti-GD2 antibody dinutuximab induces antibody-dependent cell-mediated cytotoxicity (ADCC). Galunisertib, an inhibitor TGFβR1, was examined for its ability to enhance efficacy in combination with human ex vivo activated NK (aNK) cells against neuroblastoma.TGFB1 and TGFBR1 mRNA expression determined 249 primary tumors by microarray analysis. The galunisertib inhibit SMAD activity induced patient blood bone marrow plasmas tested. impact on...
The pathogenesis of acute myeloid leukemia (AML) involves serial acquisition mutations controlling several cellular processes, requiring combination therapies affecting key downstream survival nodes in order to treat the disease effectively. BCL2 selective inhibitor venetoclax has potent anti-leukemia efficacy; however, resistance can occur due its inability inhibit MCL1, which is stabilized by MAPK pathway. In this study, we aimed determine efficacy concomitant targeting and pathways MEK1/2...
This survey study aims to determine the prevalence of pregnancy complications and infertility in female physicians comparison general population. Risk factors, workplace environment, education are also examined.Physicians undertake long training have stressful work environments during optimal childbearing years. While growing literature indicates increased rates surgeons, all specialties is unknown.An anonymous, voluntary was distributed via private physician social media groups. It queried...
Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, an ubiquitin-conjugating that promotes formation monomeric results its translocation and subsequent function. Therefore, inhibition UBE2N may reactivate by promoting nuclear accumulation. Here, we show NSC697923, a novel inhibitor, exhibits potent cytotoxicity panel...
Increasing evidence suggests that inflammatory cytokines play a critical role in tumor initiation and progression. A cancer stem cell (CSC)-like subpopulation neuroblastoma is known to be marked by expression of the G-CSF receptor (G-CSFR). Here, we report on mechanistic contributions G-CSFR CSCs. Specifically, demonstrate ligand selectively activates STAT3 within CSC subpopulations, promoting their expansion vitro vivo. Exogenous enhances growth metastasis human xenograft murine models. In...
Research has been inconsistent in its quest to discover whether dispositional creativity is associated with more or less unethical behavior. Drawing on social cognitive theory, we propose that moral disengagement and imagination are 2 parallel mechanisms encourage inhibit behavior, which of these mediation processes occur depends identity. Study 1, a 3-wave study food service organization, shows employees high both identity likely be morally disengaged behave unethically. The results...
Neuroblastoma is an aggressive pediatric malignancy which >98% p53 wild-type at diagnosis. As a primary repressor of activity and part p53-activated negative feedback loop, targeting mouse double minute 2 homolog (MDM2) attractive therapeutic approach to reactivation p53. Since development the first selective MDM2 inhibitor, Nutlin-3a, newer compounds have been developed for increased potency improved bioavailability. Herein, we sought determine efficacy specificity second-generation RG7388,...
The potential for avoiding acquired resistance to therapy has been proposed as one compelling theoretical advantage of antiangiogenic based on the normal genetic status target vasculature. However, previous work demonstrated that tumors may resume growth after initial inhibition if blockade is continued an extended period. mechanisms this recurrent are unclear. In these studies, we characterized molecular changes in vasculature during apparent resumption xenograft by vascular endothelial...
MYCN is a major driver of neuroblastoma tumorigenesis and amplification the worst prognostic indicator aggressive NB. To identify potentially therapeutic tumor suppressor microRNAs for NB, we utilized conditional system to simulate MYCN-amplified nonamplified types performed genome-wide search target microRNA promoters differentially repressed under high conditions. We identified 20 gene hosting 30 that were directly bound regulated by MYCN. Eleven these genes showed significant clinical...